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US5667491A
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Method for rapid temporal control of molecular transport across tissue
Assignee: Massachusetts Institute of Technology
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Filing: 1995-06-07
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Granted: 1997-09-16
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Expires: 2015-06-07
Abstract
Abstract A method is disclosed for treating tissue in response to a stimulus generated by the tissue. In one embodiment, the method transdermally treats an organism in response to a stimulus. In this embodiment, the medication is applied to epidermis of the organism, and the epidermis is electroporated in response to a stimulus, whereby the medication passes through the epidermis at a rate sufficient to alter the stimulus, thereby transdermally treating the organism. In another embodiment, the method measures a blood component content of blood. A portion of epidermis is electroporated to cause an aqueous fluid to be directed through an electroporated epidermis to a surface of the epidermis. Thereafter, the blood component content of the aqueous fluid is measured for correlation with a known aqueous fluid blood component content associated with a known concentration of blood component in the blood. The blood component concentration of the blood can thereby be measured. In still another embodiment, the method includes directing a medication to the tissue which can alter the stimulus when the tissue is electroporated, and electroporating the tissue in response to a stimulus, whereby the medication passes through the tissue in an amount sufficient to alter the stimulus, thereby treating the organism.
Inventors
- 👤 Uwe Pliquett
- 👤 Mark R. Prausnitz
- 👤 James C. Weaver
- 👤 Robert S. Langer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 18:03
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0412; A61B; A61B5/00; A61B5/145; A61B5/14507; A61B5/1451; A61B5/14514; A61B5/41; A61B5/414; A61B5/418; A61K; A61K31/00; A61K41/00; A61K41/0047; A61K48/00; A61N1/18; A61N1/32; A61N1/325; A61N1/327; C; C07; C07K; C07K14/00; C07K14/82; C12; C12N; C12N15/00; C12N15/09; C12N15/87; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/66; G01N33/84; A61B5/14532; A61N1/0452
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
85 words
A method for transdermally treating an organism in response to an intrinsic condition, comprising the steps of: a) applying a medication to epidermis of the organism; b) electroporating the epidermis at a first voltage pulse condition in response to said intrinsic condition to initiate delivery of the medication through the epidermis; and c) electroporating said epidermis at a second voltage pulse condition, whereby the medication continues to pass through the epidermis at a rate sufficient to alter the intrinsic condition, thereby rapidly treating the organism.
Claim 2
Independent Claim
85 words
A method for transdermally treating an organism in response to an intrinsic condition, comprising the steps of: a) applying a medication to epidermis of the organism; b) electroporating the epidermis at a first voltage pulse condition in response to said intrinsic condition to initiate delivery of the medication through the epidermis; and c) electroporating said epidermis at a second voltage pulse condition, whereby the medication continues to pass through the epidermis at a rate sufficient to alter the intrinsic condition, thereby rapidly treating the organism.
Claim 3
Dependent Claim
19 words
A method of claim 1 wherein the medication is applied to the epidermis before onset of the intrinsic condition.
Claim 4
Dependent Claim
15 words
A method of claim 2 wherein the electroporation response to the intrinsic condition is volitional.
Claim 5
Dependent Claim
11 words
A method of claim 3 wherein the medication is an analgesic.
Claim 6
Dependent Claim
10 words
A method of claim 4 wherein the medication is aspirin.
Claim 7
Dependent Claim
11 words
A method of claim 5 wherein the intrinsic condition is pain.
Claim 8
Dependent Claim
18 words
A method of claim 1 wherein the tissue is electroporated when the intrinsic condition passes a threshold value.
Claim 9
Dependent Claim
18 words
A method of claim 7 wherein the tissue is electroporated when the intrinsic condition exceeds a threshold value.
Claim 10
Dependent Claim
27 words
A method of claim 8 wherein the tissue is electroporated in an amount sufficient to cause the medication to reduce the intrinsic condition across the threshold value.
Claim 11
Dependent Claim
32 words
A method of claim 7 wherein the tissue is electroporated when the intrinsic condition passes below a threshold value, and wherein the medication causes the intrinsic condition to exceed said threshold value.
Claim 12
Dependent Claim
33 words
A method of claim 7 wherein the tissue is electroporated in an amount sufficient to cause the medication to alter the intrinsic condition across the threshold value in less than about ten minutes.
Claim 13
Dependent Claim
33 words
A method of claim 11 wherein the tissue is electroporated in an amount sufficient to cause the medication to alter the intrinsic condition across the threshold value in less than about one minute.
Claim 14
Independent Claim
93 words
A method for treating an organism in response to an intrinsic condition susceptible to rapid alleviation, comprising the steps of: a) directing a medication to tissue of the organism which can alter the intrinsic condition when the tissue is electroporated; b) electroporating the tissue at a first voltage pulse condition in response to the intrinsic condition to initiate delivery of the medication through the tissue; and c) electroporating said tissue at a second voltage pulse condition, whereby the medication passes through the tissue at a rate sufficient to rapidly alleviate the intrinsic condition.
Claim 15
Independent Claim
93 words
A method for treating an organism in response to an intrinsic condition susceptible to rapid alleviation, comprising the steps of: a) directing a medication to tissue of the organism which can alter the intrinsic condition when the tissue is electroporated; b) electroporating the tissue at a first voltage pulse condition in response to the intrinsic condition to initiate delivery of the medication through the tissue; and c) electroporating said tissue at a second voltage pulse condition, whereby the medication passes through the tissue at a rate sufficient to rapidly alleviate the intrinsic condition.
Claim 16
Dependent Claim
19 words
A method of claim 13 wherein the medication is directed to the tissue before occurrence of the intrinsic condition.
Claim 17
Dependent Claim
11 words
A method of claim 14 wherein the medication is an analgesic.
Claim 18
Dependent Claim
10 words
A method of claim 15 wherein the analgesic is aspirin.
Claim 19
Dependent Claim
11 words
A method of claim 16 wherein the intrinsic condition is pain.
Claim 20
Dependent Claim
15 words
A method of claim 17 wherein the electroporation response to the intrinsic condition is volitional.
Claim 21
Dependent Claim
23 words
A method of claim 13 wherein the tissue which is treated by electroporation is distinct from the tissue which generates the intrinsic condition.
Claim 22
Dependent Claim
18 words
A method of claim 13 wherein the tissue is electroporated when the intrinsic condition passes a threshold value.
Claim 23
Dependent Claim
17 words
A method claim 20 wherein the tissue is electroporated when the intrinsic condition exceeds a threshold value.
Claim 24
Dependent Claim
27 words
A method of claim 21 wherein the tissue is electroporated in an amount sufficient to cause the medication to reduce the intrinsic condition across the threshold value.
Claim 25
Dependent Claim
32 words
A method of claim 20 wherein the tissue is electroporated when the intrinsic condition passes below a threshold value, and wherein the medication causes the intrinsic condition to exceed said threshold value.
Claim 26
Dependent Claim
33 words
A method of claim 20 wherein the tissue is electroporated in an amount sufficient to cause the medication to alter the intrinsic condition across the threshold value in less than about ten minutes.
Claim 27
Dependent Claim
33 words
A method of claim 24 wherein the tissue is electroporated in an amount sufficient to cause the medication to alter the intrinsic condition across the threshold value in less than about one minute.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2000-09-15 | 2001-03-17 | 2001-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-09-15 | 2005-03-17 | 2005-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-09-15 | 2009-03-17 | 2009-09-16 | $7700.00 | Window Closed / Lapsed |