Patent US5666956A successfully refreshed from Google Patents.
US5666956A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Instrument and method for non-invasive monitoring of human tissue analyte by measuring the body's infrared radiation
Assignee: INFRATEC Inc
•
Filing: 1996-05-20
•
Granted: 1997-09-16
•
Expires: 2016-05-20
Abstract
Abstract A method and an instrument for the non-invasive detection of an analyte (e.g. glucose) concentration in human body tissue such as blood is disclosed. The instrument measures analyte (e.g. glucose) concentration by detecting the infrared radiation naturally emitted by a human body using infrared detector with combination of adequate filters such as for example negative correlation filter or narrow band filters or other detector-filter assemblies. The method and instrument is based on the discovery that natural infrared emission from the human body, especially from the tympanic membrane, is modulated by the state of the emitting tissue. Spectral emissivity of human infrared radiation from the tympanic membrane consists of spectral information of the tissue (e.g. blood) analyte (e.g. glucose). This can be directly correlated with the blood analyte concentration, for example, the blood glucose concentration.
Inventors
- 👤 Janusz Michal Buchert
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 20:28
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/14532; G; G01; G01J; G01J5/00; G01J5/0003; G01J5/0011; G01J5/0022; G01J5/0025; G01J5/02; G01J5/08; G01J5/0801; G01J5/0802; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/31; G01N21/35; G01N21/3504; G01N2021/3531
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
95 words
A method of determining a human body tissue analyte concentration by non invasive measurement of emission spectral lines characteristic to a body tissue analyte in an infrared spectral region emitted naturally by a human body as heat, comprising: a. measuring a spectral intensity of said emission spectral lines; b. said emission spectral lines having a wavelength dependence of tissue constituents; c. detecting the emission spectral lines at a predetermined emission wavelength; d. analyzing the emission spectral lines in said infrared spectral region; e. correlating said spectral intensity of emission spectral lines with body analyte concentrations.
Claim 2
Independent Claim
95 words
A method of determining a human body tissue analyte concentration by non invasive measurement of emission spectral lines characteristic to a body tissue analyte in an infrared spectral region emitted naturally by a human body as heat, comprising: a. measuring a spectral intensity of said emission spectral lines; b. said emission spectral lines having a wavelength dependence of tissue constituents; c. detecting the emission spectral lines at a predetermined emission wavelength; d. analyzing the emission spectral lines in said infrared spectral region; e. correlating said spectral intensity of emission spectral lines with body analyte concentrations.
Claim 3
Dependent Claim
44 words
A method as in claim 1, for determining blood glucose concentration by non-invasive measurement of emission spectral lines characteristic to a body tissue analyte in an infrared spectral region emitted naturally by a human body's tympanic membrane in an infrared wavelength spectrum as heat.
Claim 4
Dependent Claim
80 words
An instrument for determining a human body tissue analyte concentration by non-invasive measurement of emission spectral lines characteristic to a body tissue analyte in an infrared spectral region emitted naturally by a human body as heat, comprising: a. a means for detecting said emission spectral lines at a predetermined infrared wavelength; b. a means for detecting a spectral intensity of the emission spectral lines; c. a means for correlating the intensity of emission spectral lines with the tissue analyte concentration.
Claim 5
Dependent Claim
80 words
An instrument for determining a human body tissue analyte concentration by non-invasive measurement of emission spectral lines characteristic to a body tissue analyte in an infrared spectral region emitted naturally by a human body as heat, comprising: a. a means for detecting said emission spectral lines at a predetermined infrared wavelength; b. a means for detecting a spectral intensity of the emission spectral lines; c. a means for correlating the intensity of emission spectral lines with the tissue analyte concentration.
Claim 6
Dependent Claim
76 words
The instrument of claim 3, wherein the detecting means comprises a detector means and an analyzing means for a wavelength selecting means of the emission spectral lines; detector means for detecting the intensity of received emission spectral lines from said analyzing means producing an electronic output signal, and wavelength selecting means for allowing only significant wavelengths of tissue analyte emission spectral lines an natural infrared radiation emitted by the human body to reach the detector means.
Claim 7
Dependent Claim
14 words
The instrument of claim 4, wherein the detector means is an infrared energy sensor.
Claim 8
Dependent Claim
42 words
The instrument of claim 4, wherein the analyzing means comprises a filter means for filtering the emission spectral lines to allow only wavelengths significant to the tissue analyte emission spectral lines to pass or to be absorbed before reaching the detector means.
Claim 9
Dependent Claim
39 words
The instrument of claim 3, where the correlating means is an electronic means comprises electronic amplifiers, signal conditioners and a microcomputer for correlating a state of the electronic output signal from the detecting means with the tissue analyte concentration.
Claim 10
Dependent Claim
44 words
An instrument of claim 3 for non-invasive blood glucose concentration measurement based on measurement of emission spectral lines characteristic to a body tissue analyte in an infrared spectral region emitted naturally by a human body tympanic membrane in an infrared wavelength spectrum as heat.
Claim 11
Dependent Claim
216 words
An instrument for non-invasive tissue analyte concentration measurement based on measurement of emission spectral lines characteristic to a human body tissue analyte in an infrared spectral region emitted naturally by a tympanic membrane as heat, comprising: a. a speculum for insertion into an ear canal; b. a plastic cover made of a material transparent to radiation in an infrared spectral region; c. an infrared wave guide for receiving infrared radiation from the tympanic membrane and for illuminating all windows of a detecting system; d. the infrared wave guide is selected from the group consisting of a mirror, reflector, lens, hollow tube, and a fiber optic; e. an optical valve consisting of a shutter or chopper; f. the detecting system consisting of an optical infrared filter set and a detector sensitive in an infrared region of human body heat radiation; g. an optical infrared filter set consisting of a negative correlating filter or narrow band filters; h. a detector system sensitive in the infrared region of human body heat radiation consisting of at least two sensing areas electronically connected so that their outputs are subtracted; i. said detector connected with electronics, a microprocessor and a display system for forming, calculating, and displaying an electrical signal from the detector to show a numerical value of the analyte concentration.
Claim 12
Dependent Claim
216 words
An instrument for non-invasive tissue analyte concentration measurement based on measurement of emission spectral lines characteristic to a human body tissue analyte in an infrared spectral region emitted naturally by a tympanic membrane as heat, comprising: a. a speculum for insertion into an ear canal; b. a plastic cover made of a material transparent to radiation in an infrared spectral region; c. an infrared wave guide for receiving infrared radiation from the tympanic membrane and for illuminating all windows of a detecting system; d. the infrared wave guide is selected from the group consisting of a mirror, reflector, lens, hollow tube, and a fiber optic; e. an optical valve consisting of a shutter or chopper; f. the detecting system consisting of an optical infrared filter set and a detector sensitive in an infrared region of human body heat radiation; g. an optical infrared filter set consisting of a negative correlating filter or narrow band filters; h. a detector system sensitive in the infrared region of human body heat radiation consisting of at least two sensing areas electronically connected so that their outputs are subtracted; i. said detector connected with electronics, a microprocessor and a display system for forming, calculating, and displaying an electrical signal from the detector to show a numerical value of the analyte concentration.
References Cited (Backward Citations)
US3958560A
Cited
US3963019A
Cited
US4014321A
Cited
US4224520A
Cited
US4659234A
Cited
US4790324A
Cited
US4797840A
Cited
US4875486A
Cited
US5072732A
Cited
US4883953A
Cited
US4882492A
Cited
US5024533A
Cited
US4932789A
Cited
US5009230A
Cited
US5028787A
Cited
US5068536A
Cited
US5086229A
Cited
US5139023A
Cited
US5041723A
Cited
US5267152A
Cited
US5140985A
Cited
US5070874A
Cited
US5054487A
Cited
US5169234A
Cited
US5145257A
Cited
US5146091A
Cited
US5179951A
Cited
US5119819A
Cited
US5436455A
Cited
US5159936A
Cited
US5169235A
Cited
US5267151A
Cited
US5167235A
Cited
US5178464A
Cited
US5127742A
Cited
US5300778A
Cited
US5452716A
Cited
US5370114A
Cited
US5487607A
Cited
US5381796A
Cited
US5424545A
Cited
US5360004A
Cited
US5379764A
Cited
US5448992A
Cited
US5398681A
Cited
US5313941A
Cited
US5515847A
Cited
US5368038A
Cited
US5341805A
Cited
US5460177A
Cited
US5383452A
Cited
US5435309A
Cited
US5459317A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-09-15 | 2001-03-17 | 2001-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-09-15 | 2005-03-17 | 2005-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-09-15 | 2009-03-17 | 2009-09-16 | $7700.00 | Window Closed / Lapsed |