Patent US5658551A successfully refreshed from Google Patents.
US5658551A
Expired / Lapsed
US
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Stable microbubbles suspensions injectable into living organisms
Assignee: Bracco International BV
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Filing: 1995-06-01
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Granted: 1997-08-19
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Expires: 2015-06-01
Abstract
Abstract Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
Inventors
- 👤 Michel Schneider
- 👤 Daniel Bichon
- 👤 Philippe Bussat
- 👤 Jerome Puginier
- 👤 Eva Hybl-Sutherland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:04
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/22; A61K49/222; A61K49/223; A61K49/227
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
59 words
An injectable composition comprising, as a suspension in an aqueous carrier phase, gas microbubbles of physiologically acceptable, fluorine-containing entrappable gas or a mixture of a fluorine-containing entrappable gas with CO 2 , N 2 or NO 2 stabilized by dissolved or dispersed surfactants at least one of which is a saturated film forming phospholipid in laminar or lamellar form.
Claim 2
Dependent Claim
59 words
An injectable composition comprising, as a suspension in an aqueous carrier phase, gas microbubbles of physiologically acceptable, fluorine-containing entrappable gas or a mixture of a fluorine-containing entrappable gas with CO 2 , N 2 or NO 2 stabilized by dissolved or dispersed surfactants at least one of which is a saturated film forming phospholipid in laminar or lamellar form.
Claim 3
Dependent Claim
13 words
A suspension according to claim 1, wherein said flourine-containing gas is a freon.
Claim 4
Dependent Claim
16 words
A suspension according to claim 1, wherein the average bubble size is less than 50 μm.
Claim 5
Dependent Claim
13 words
A suspension according to claim 3, wherein said bubble size is 0.5-50 μm.
Claim 6
Dependent Claim
13 words
A suspension according to claim 1 in the form of an aqueous suspension.
Claim 7
Dependent Claim
20 words
A suspension according to claim 1, wherein the lamellar phospholipid is in the form of mono- or pluri-molecular membrane layers.
Claim 8
Dependent Claim
14 words
A suspension according to claim 6, wherein the lamellar phospholipid is a saturated phopholipid.
Claim 9
Dependent Claim
22 words
A suspension according to claim 7, wherein the phospholipid is selected from phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidyglycerol, phosphatidylinositol, cardiolipin and sphingomyelin.
Claim 10
Dependent Claim
25 words
A suspension according to claim 8, further containing substances selected from dicetylphosphate, cholesterol, ergosterol, phytosterol, sitosterol, lanosterol, tocopherol, propyl gallate, ascorbyl palmitate and butylated hydroxy-toluene.
Claim 11
Dependent Claim
40 words
A suspension according to claim 1, further containing dissolved viscosity enhancers or stabilizers selected from linear and cross-linked poly- and oligo-saccharides, sugars, hydrophilic polymers and iodinated compounds in a weight ratio to the surfactants comprised between about 1:5 to 100:1.
Claim 12
Dependent Claim
30 words
A suspension according to claim 1, further comprising up to 50% by weight of non-laminar surfactants selected from fatty acids, ester and ethers of fatty acids and alcohols with polyols.
Claim 13
Dependent Claim
20 words
A suspension according to claim 11, wherein the polyols are polyalkylene glycols, polyalkylenated sugars and other carbohydrates, and polyalkylenated glycerol.
Claim 14
Dependent Claim
12 words
A suspension according to claim 1 containing 10 7 7-10 8 microbubbles/ml.
Claim 15
Dependent Claim
12 words
A suspension according to claim 1 containing 10 8 -10 9 microbubbles/ml.
Claim 16
Dependent Claim
12 words
A suspension according to claim 1 containing 10 10 -10 11 .
Claim 17
Dependent Claim
16 words
A suspension according to claim 1, wherein the microbubbles also contain 133 Xe or 81 Kr.
References Cited (Backward Citations)
DE327490C
Cited
US4370349A
Cited
US4224179A
Cited
US4229360A
Cited
US4229360B1
Cited
US4192859A
Cited
EP0052575A2
Cited
EP0077752A2
Cited
US4466442A
Cited
GB2134869A
Cited
GB2135647A
Cited
EP0123235A2
Cited
US4544545A
Cited
US4900540A
Cited
EP0131540A2
Cited
US4832941A
Cited
US4927623A
Cited
US5283067A
Cited
US5089181A
Cited
WO1988007365A2
Cited
WO1988009165A1
Cited
EP0320433A2
Cited
EP0324938B1
Cited
US4844882A
Cited
US5425366A
Cited
US5088499A
Cited
US5271928A
Cited
US5531980A
Cited
US5536490A
Cited
US5409688A
Cited
US5352436A
Cited
US5536489A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-08-18 | 2001-02-17 | 2001-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-08-18 | 2005-02-17 | 2005-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-08-18 | 2009-02-17 | 2009-08-19 | $7700.00 | Window Closed / Lapsed |