US4832941A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Contrast medium for ultrasonic examinations and process for its preparation
Assignee: Takeda GmbH
•
Filing: 1986-08-14
•
Granted: 1989-05-23
•
Expires: 2006-08-14
Abstract
Abstract A constrast medium for ultrasonic examinations, in particular for echocardiography, based on a suspension of gas bubbles in a pharmacologically acceptable, aqueous liquid vehicle having a physiological electrolyte content, containing (A) a pharmacologically acceptable polypeptide and/or polysaccharide and/or a derivative thereof, (B) a pharmacologically acceptable vegetable oil and (C) a pharmacologically acceptable soluble iron(III) salt, and a process for its preparation. This contrast medium is able to penetrate the pulmonary capillaries and thus makes possible, after intravenous injection, inter alia echocardiographic examination of the left ventricle.
Inventors
- 👤 Klaus Berwing
- 👤 Martin Schlepper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:11
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/22; A61K49/222; A61K49/223
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
123 words
Contrast medium using a suspension of gas bubbles for ultrasonic examinations in a physiologically acceptable aqueous liquid vehicle having a physiological electrolyte content, comprising: a liquid vehicle containing in admixture by weight: (A) 1 to 5 percent of a polysaccharide gelatin or a gelatin derivative including oxypoly gelatin, degraded gelatin, gelatin polysuccinate, cross linked polypeptide, dextran or a mixture thereof, (B) 1 to 10 percent of a pharmacologically acceptable vegetable oil selected from the group consisting of soja oil, maise oil, sesame oil, arachis oil, or mixtures thereof and (C) 0.01 to 0.05 percent of a pharmacologically acceptable soluble iron (III) salt; and wherein the gas comprises air, nitrogen or inert gas or mixtures thereof in bubbles smaller in diameter than 7 μm.
Claim 2
Dependent Claim
123 words
Contrast medium using a suspension of gas bubbles for ultrasonic examinations in a physiologically acceptable aqueous liquid vehicle having a physiological electrolyte content, comprising: a liquid vehicle containing in admixture by weight: (A) 1 to 5 percent of a polysaccharide gelatin or a gelatin derivative including oxypoly gelatin, degraded gelatin, gelatin polysuccinate, cross linked polypeptide, dextran or a mixture thereof, (B) 1 to 10 percent of a pharmacologically acceptable vegetable oil selected from the group consisting of soja oil, maise oil, sesame oil, arachis oil, or mixtures thereof and (C) 0.01 to 0.05 percent of a pharmacologically acceptable soluble iron (III) salt; and wherein the gas comprises air, nitrogen or inert gas or mixtures thereof in bubbles smaller in diameter than 7 μm.
Claim 3
Dependent Claim
28 words
Contrast medium according to claim 1, characterized in that the liquid vehicle contains as further constituent (D) 0 to 20% (based on constituent A) of a sugar alcohol.
Claim 4
Dependent Claim
19 words
Contrast medium according to claim 1, characterized in that the liquid vehicle contains as further constituent (E) a phospholipid.
Claim 5
Dependent Claim
18 words
Contrast medium according to claim 1, characterized in that the liquid vehicle contains as further constituent (F) glycerol.
Claim 6
Dependent Claim
19 words
Contrast medium according to claim 1, characterized in that the liquid vehicle contains as further constituent (G) a preservative.
Claim 7
Dependent Claim
25 words
Contrast medium according to claim 1, characterized in that the liquid vehicle contains as pharmacologically acceptable soluble iron (III) salt a Sodium iron(III) gluconate complex.
Claim 8
Dependent Claim
28 words
Contrast medium according to claim 1 wherein the liquid vehicle contains as sugar alcohol at least one member selected from the group consisting of sorbitol, maltito, galactitol xylitol.
Claim 9
Dependent Claim
16 words
Contrast medium according to claim 1, characterized in that the liquid vehicle contains as phospholipid lecithin.
Claim 10
Dependent Claim
83 words
Contrast medium according to claim 4, characterized in that the liquid vehicle contains 1 to 5% by weight of constituent (A), 1 to 10% by weight of constituent (B), 0.01 to 0.05% by weight of constituent (C), 0 to 1% by weight of constituent (D), 0 to 5% by weight of constituent (E), 0 to 2% by weight of constituent (F) and 1 to 10% by volume of a gas in the form of bubbles with a diameter of less than 7 μm.
Claim 11
Dependent Claim
37 words
Process for the preparation of the contrast medium according to claim 1, suspending said gas in said liquid vehicle manually, mechanically or by the action of ultrasound to form bubbles thereof having diameters less than 7 nm.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-22 | 1992-11-21 | 1993-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-22 | 1996-11-21 | 1997-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-22 | 2000-11-21 | 2001-05-23 | $7700.00 | Window Closed / Lapsed |