US5652355A
Expired / Lapsed
US
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Hybrid oligonucleotide phosphorothioates
Assignee: WORESTER FOUNDATION FOR BIOMEDICAL RESEARCH Inc
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Filing: 1992-07-23
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Granted: 1997-07-29
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Expires: 2012-07-23
Abstract
Abstract The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonueleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
Inventors
- 👤 Valeri Metelev
- 👤 Sudhir Agrawal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:36
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/113; A; A61; A61P; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P33/00; A61P33/02; A61P35/00; A61P9/00; A61P9/10; A61P9/12; C07; C07H; C07H21/00; C12N15/1131; C12N15/1132; C12N2310/00; C12N2310/30; C12N2310/31; C12N2310/313; C12N2310/315; C12N2310/32; C12N2310/321; C12N2310/34; C12N2310/341; C12N2310/346; C12N2310/35; C12N2310/352; C12N2310/3521
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
50 words
A hybrid oligonucleotide that is complementary to a target RNA, the hybrid oligonucleotide consisting of phosphorothioate nucleotides and comprising a segment of at least two contiguous 2'-O-methyl-substituted ribonucleotides as the terminal two nucleotides at each end of the oligonucleotide, and further comprising a segment of at least three contiguous deoxyribonucleotides.
Claim 2
Dependent Claim
50 words
A hybrid oligonucleotide that is complementary to a target RNA, the hybrid oligonucleotide consisting of phosphorothioate nucleotides and comprising a segment of at least two contiguous 2'-O-methyl-substituted ribonucleotides as the terminal two nucleotides at each end of the oligonucleotide, and further comprising a segment of at least three contiguous deoxyribonucleotides.
Claim 3
Dependent Claim
21 words
A hybrid oligonucleotide according to claim 1, wherein the deoxyribonucleotide is present in a segment of at least four contiguous deoxyribonucleotides.
Claim 4
Dependent Claim
14 words
An oligonucleotide according to claim 1 comprising from about 6 to about 50 nucleotides.
Claim 5
Dependent Claim
14 words
An oligonucleotide according to claim 2 comprising from about 6 to about 50 nucleotides.
Claim 6
Dependent Claim
16 words
An oligonucleotide according to claim 1 wherein the target RNA is a RNA from a virus.
Claim 7
Dependent Claim
16 words
An oligonucleotide according to claim 2 wherein the target RNA is a RNA from a virus.
Claim 8
Dependent Claim
16 words
An oligonucleotide according to claim 3 wherein the target RNA is a RNA from a virus.
Claim 9
Dependent Claim
16 words
An oligonucleotide according to claim 4 wherein the target RNA is a RNA from a virus.
Claim 10
Dependent Claim
15 words
An oligonucleotide according to claim 1 wherein the target RNA is a RNA from HIV.
Claim 11
Dependent Claim
15 words
An oligonucleotide according to claim 2 wherein the target RNA is a RNA from HIV.
Claim 12
Dependent Claim
15 words
An oligonucleotide according to claim 3 wherein the target RNA is a RNA from HIV.
Claim 13
Dependent Claim
15 words
An oligonucleotide according to claim 4 wherein the target RNA is a RNA from HIV.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2000-07-28 | 2001-01-27 | 2001-07-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-07-28 | 2005-01-27 | 2005-07-29 | $3760.00 | Window Closed / Lapsed |
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