US5622699A
Expired / Lapsed
US
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Method of identifying molecules that home to a selected organ in vivo
Assignee: Sanford Burnham Prebys Medical Discovery Institute
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Filing: 1995-09-11
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Granted: 1997-04-22
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Expires: 2015-09-11
Abstract
Abstract The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
Inventors
- 👤 Erkki Ruoslahti
- 👤 Renata Pasqualini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 21:34
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/5005; G01N33/5008; G01N33/5044; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K47/64; A61K47/6425; C; C07; C07K; C07K1/00; C07K1/04; C07K1/047; G01N33/502; G01N33/5058; G01N33/5082; G01N33/5088; G01N33/53; G01N33/566; G01N33/567
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
83 words
A method of obtaining a molecule selected from the group consisting of a peptide, a polypeptide, a protein, and a fragment of a protein that homes to a selected organ or tissue, comprising the steps of: a. administering to a subject a phage display library expressing diverse molecules; b. collecting a sample of the selected organ or tissue; and c. identifying a molecule that homes to said selected organ or tissue, wherein said molecule is expressed on a phage present in said sample.
Claim 2
Independent Claim
83 words
A method of obtaining a molecule selected from the group consisting of a peptide, a polypeptide, a protein, and a fragment of a protein that homes to a selected organ or tissue, comprising the steps of: a. administering to a subject a phage display library expressing diverse molecules; b. collecting a sample of the selected organ or tissue; and c. identifying a molecule that homes to said selected organ or tissue, wherein said molecule is expressed on a phage present in said sample.
Claim 3
Dependent Claim
21 words
The method of claim 1, wherein said selected organ or tissue is selected from the group consisting of brain and kidney.
Claim 4
Dependent Claim
14 words
The method of claim 1, wherein said selected organ or tissue is a tumor.
Claim 5
Dependent Claim
25 words
The method of claim 1, wherein said molecule is selected from the group consisting of a polypeptide, a protein and a fragment of a protein.
Claim 6
Dependent Claim
11 words
The method of claim 1, wherein said molecule is a peptide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-04-21 | 2000-10-21 | 2001-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-04-21 | 2004-10-21 | 2005-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-04-21 | 2008-10-21 | 2009-04-22 | $7700.00 | Window Closed / Lapsed |