Patent US5601526A successfully refreshed from Google Patents.
US5601526A
Expired / Lapsed
US
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Ultrasound therapy apparatus delivering ultrasound waves having thermal and cavitation effects
Assignee: Institut National de la Santé et de la Recherche Médicale
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Filing: 1992-12-21
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Granted: 1997-02-11
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Expires: 2012-12-21
Abstract
Abstract A method and apparatus for performing therapy using ultrasound. The apparatus uses a treatment device having at least one piezoelectric transducer element to supply ultrasonic waves focussed onto a focal point or region that determines the tissue zone submitted to therapy. The treatment device, which is controlled by a control device, supplies two types of ultrasonic waves, the first one being thermal waves that produce a predominantly thermal effect on the tissue being treated and the second one being cavitation waves that produce a predominantly cavitation effect on the tissue to be treated.
Inventors
- 👤 Jean-Yves Chapelon
- 👤 Dominique Cathignol
- 👤 Albert Gelet
- 👤 Emmanuel Blanc
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:23
CPC Classifications
A; A61; A61N; A61N7/00; A61N7/02; A61B; A61B17/00; A61B17/22; A61B17/22004; A61B2017/22005; A61B2017/22007; A61B2017/22008; A61B2017/22009; A61F; A61F7/00; A61F2007/0086
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
110 words
A therapy method using ultrasound for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, by supplying ultrasonic waves focused onto a focal point or region F determining a tissue zone to be submitted to said therapy, which comprises supplying ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on tissue to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissue to be treated, said two types of waves being applied for a time sufficient to effect therapy by destroying at least a portion of said tissue.
Claim 2
Dependent Claim
110 words
A therapy method using ultrasound for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, by supplying ultrasonic waves focused onto a focal point or region F determining a tissue zone to be submitted to said therapy, which comprises supplying ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on tissue to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissue to be treated, said two types of waves being applied for a time sufficient to effect therapy by destroying at least a portion of said tissue.
Claim 3
Dependent Claim
125 words
A therapy method using ultrasound for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, by supplying ultrasonic waves focused onto a focal point or region F determining a tissue zone to be submitted to said therapy, which comprises supplying ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on tissue to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissue to be treated, said two types of waves being applied for a time sufficient to effect therapy by destroying at least a portion of said tissue and wherein said thermal ultrasonic waves are supplied at least at a beginning of treatment.
Claim 4
Dependent Claim
125 words
A therapy method using ultrasound for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, by supplying ultrasonic waves focused onto a focal point or region F determining a tissue zone to be submitted to said therapy, which comprises supplying ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on tissue to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissue to be treated, said two types of waves being applied for a time sufficient to effect therapy by destroying at least a portion of said tissue and wherein said thermal ultrasonic waves are supplied at least at a beginning of treatment.
Claim 5
Dependent Claim
28 words
The method according to claim 2, wherein said cavitation ultrasonic waves are supplied after an adjustable predetermined time interval for allowing preheating of the tissue to be treated.
Claim 6
Dependent Claim
19 words
The method according to claim 3, wherein said cavitation ultrasonic waves are supplied simultaneously with said thermal ultrasonic waves.
Claim 7
Dependent Claim
51 words
The method according to claim 3, wherein acoustic power of said thermal ultrasonic waves is lower than a cavitation threshold whereas acoustic power of said cavitation ultrasonic waves is at least equal to the cavitation threshold, said cavitation threshold being a function of the tissue of the mammal to be treated.
Claim 8
Dependent Claim
24 words
The method according to claim 3, wherein the frequency of said cavitation ultrasonic waves is lower than the frequency of said thermal ultrasonic waves.
Claim 9
Dependent Claim
22 words
The method according to claim 3, wherein said cavitation ultrasound waves include a negative amplitude component of a nature to initiate cavitation.
Claim 10
Dependent Claim
25 words
The method according to claim 3, wherein said cavitation ultrasound waves are supplied for a duration of between about 0.5 microseconds and about 100 milliseconds.
Claim 11
Dependent Claim
29 words
The method according to claim 3, wherein said cavitation ultrasound waves are supplied by successive pulses, repetition frequency of which varies from about 1 Hz to about 1 KHz.
Claim 12
Dependent Claim
24 words
The method according to claim 3, wherein the duration of said adjustable predetermined time interval is between about 100 milliseconds and about 10 seconds.
Claim 13
Dependent Claim
51 words
The method according to claim 3, wherein the total duration of treatment of the tissue region determined by the focal point or region F by means of the said ultrasound waves is between about 100 milliseconds and 10 seconds, this total duration including at least one pulse of cavitation ultrasound waves.
Claim 14
Dependent Claim
25 words
The method according to claim 3, wherein the frequency of transmission of said cavitation ultrasound waves is between about 500 KHz and about 4 MHz.
Claim 15
Dependent Claim
46 words
The method according to claim 3, wherein the frequency of transmission of said thermal ultrasound waves is between about I 1 and about 4 MHz, said frequency being at least equal to the frequency being at least equal to the frequency of said cavitation ultrasound waves.
Claim 16
Dependent Claim
42 words
The method according to claim 3, wherein the acoustic power of said thermal ultrasound waves is lower than about 150 W/cm 2 , and the acoustic power of said cavitation ultrasound waves is at least equal to about 150 W/cm 2 .
Claim 17
Dependent Claim
58 words
The method according to claim 3, further comprising the step of providing transmission of ultrasound waves of an amplitude that varies as a function of time, said amplitude preferably increasing with the passage of time, whereby the amplitude over a first period remains below a cavitation threshold, then, in a second period becomes higher than said cavitation threshold.
Claim 18
Dependent Claim
47 words
The method according to claim 30, further comprising the step of displacing said focal point to perform point-by-point treatment, each of said points being determined by the said focal point or region F, in order to cover the entire volume of the tissue target to be treated.
Claim 19
Dependent Claim
175 words
A therapy method using ultrasound for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, by supplying ultrasonic waves focused onto a focal point or region F determining a tissue zone to be submitted to said therapy, which comprises supplying ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on tissue to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissue to be treated, said two types of waves being applied for a time sufficient to effect therapy by destroying at least a portion of said tissue, displacing said focal point to perform point-by-point treatment, each of said points being determined by the said focal point or region F, in order to cover the entire volume of the tissue target to be treated, and conducting an imaging step to acquire volume data so that said focal point may be displaced as a function of the volume of the target to be treated.
Claim 20
Dependent Claim
175 words
A therapy method using ultrasound for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, by supplying ultrasonic waves focused onto a focal point or region F determining a tissue zone to be submitted to said therapy, which comprises supplying ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on tissue to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissue to be treated, said two types of waves being applied for a time sufficient to effect therapy by destroying at least a portion of said tissue, displacing said focal point to perform point-by-point treatment, each of said points being determined by the said focal point or region F, in order to cover the entire volume of the tissue target to be treated, and conducting an imaging step to acquire volume data so that said focal point may be displaced as a function of the volume of the target to be treated.
Claim 21
Dependent Claim
58 words
The method according to claim 17, further comprising the step of displacing the focal point in order to carry out treatment of the tissue regions of said target which are most remote from said ultrasonic waves up to the tissue regions that are closest to said ultrasonic waves so as to improve effectiveness of treatment of said target.
Claim 22
Dependent Claim
69 words
The method according to claim 17, further comprising the step of displacing the focal point with a latency period between treatment of two successive points on the target to be treated in order to allow said tissue being treated to relax, said latency period being between about 1 second and 15 seconds and being employed for carrying out displacement of the focal point from one treatment point to another.
Claim 23
Dependent Claim
27 words
The method according to claim 17, further comprising the step of displacing the focal point in a random manner while excluding points that have already been treated.
Claim 24
Independent Claim
151 words
An apparatus for performing therapy using ultrasound, comprising at least one treatment device comprising at least one piezoelectric transducer element designed to provide at least said therapy for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, and control means for said device in order to carry out said therapy, said piezoelectric transducer element being designed to supply ultrasonic waves focused onto a focal point or region F determining the tissue zone to be submitted to said therapy, said apparatus further comprising control means for causing said treatment device to supply ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on the tissues to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissues to be treated when such tissues are exposed to said two types of ultrasonic waves.
Claim 25
Independent Claim
151 words
An apparatus for performing therapy using ultrasound, comprising at least one treatment device comprising at least one piezoelectric transducer element designed to provide at least said therapy for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, and control means for said device in order to carry out said therapy, said piezoelectric transducer element being designed to supply ultrasonic waves focused onto a focal point or region F determining the tissue zone to be submitted to said therapy, said apparatus further comprising control means for causing said treatment device to supply ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on the tissues to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissues to be treated when such tissues are exposed to said two types of ultrasonic waves.
Claim 26
Independent Claim
172 words
An apparatus for performing therapy using ultrasound, comprising at least one treatment device comprising at least one piezoelectric transducer element designed to provide at least said therapy for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, and control means for said device in order to carry out said therapy, said piezoelectric transducer element being designed to supply ultrasonic waves focused onto a focal point or region F determining the tissue zone to be submitted to said therapy, said apparatus further comprising control means for causing said treatment device to supply ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on the tissues to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissues to be treated when such tissues are exposed to said two types of ultrasonic waves, wherein said control means causes said treatment device to transmit thermal ultrasonic waves at least at the beginning of said treatment.
Claim 27
Independent Claim
172 words
An apparatus for performing therapy using ultrasound, comprising at least one treatment device comprising at least one piezoelectric transducer element designed to provide at least said therapy for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, and control means for said device in order to carry out said therapy, said piezoelectric transducer element being designed to supply ultrasonic waves focused onto a focal point or region F determining the tissue zone to be submitted to said therapy, said apparatus further comprising control means for causing said treatment device to supply ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on the tissues to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissues to be treated when such tissues are exposed to said two types of ultrasonic waves, wherein said control means causes said treatment device to transmit thermal ultrasonic waves at least at the beginning of said treatment.
Claim 28
Dependent Claim
33 words
The apparatus according to claim 22, wherein said control means cause said treatment device to transmit cavitation ultrasonic waves after an adjustable predetermined time interval allowing pre-heating of the tissue to be treated.
Claim 29
Dependent Claim
25 words
The apparatus according to claim 23, wherein said control means causes the transmission of cavitation ultrasonic waves simultaneously with the transmission of thermal ultrasonic waves.
Claim 30
Dependent Claim
51 words
The apparatus according to claim 23, wherein acoustic power of said thermal ultrasonic waves is lower than a cavitation threshold whereas acoustic power of said cavitation ultrasonic waves is at least equal to the cavitation threshold, said cavitation threshold being a function of the tissue of the mammal to be treated.
Claim 31
Dependent Claim
24 words
The apparatus according to claim 23, wherein a frequency of said cavitation ultrasonic waves is lower than a frequency of said thermal ultrasonic waves.
Claim 32
Dependent Claim
30 words
The apparatus according to claim 23, wherein said control means causes transmission of cavitation ultrasound waves including a negative component of the amplitude thereof of a nature to initiate cavitation.
Claim 33
Dependent Claim
28 words
The apparatus according to claim 23, wherein said control means causes transmission of cavitation ultrasound waves for a duration of between about 0.5 microseconds and about 100 milliseconds.
Claim 34
Dependent Claim
33 words
The apparatus according to claim 23, wherein said control means provides transmission of cavitation ultrasound waves by successive pulses, the repetition frequency of which varies from about 1 Hz to about 1 KHz.
Claim 35
Dependent Claim
24 words
The apparatus according to claim 23, wherein the duration of said adjustable predetermined time interval is between about 100 milliseconds and about 10 seconds.
Claim 36
Dependent Claim
50 words
The apparatus according to claim 23, wherein the total duration of treatment of the tissue region determined by the focal point or region F by means of the said ultrasound waves is between 100 milliseconds and 10 seconds, this total duration including at least one pulse of cavitation ultrasound waves.
Claim 37
Dependent Claim
24 words
The apparatus according to claim 23, wherein frequency of transmission of said cavitation ultrasound waves is between about 500 KHz and about 4 MHz.
Claim 38
Dependent Claim
37 words
The apparatus according to claim 23, wherein frequency of transmission of said thermal ultrasound waves is between about 1 and about 4 MHz, said frequency being at least equal to the frequency of said cavitation ultrasound waves.
Claim 39
Dependent Claim
40 words
The apparatus according to claim 23, wherein acoustic power of said thermal ultrasound waves is lower than 150 W/cm 2 , and the acoustic power of said cavitation ultrasound waves is at least equal to about 150 W/cm 2 .
Claim 40
Dependent Claim
57 words
The apparatus according to claim 23, wherein said control means provides transmission of ultrasound waves of an amplitude that varies as a function of time, said amplitude preferably increasing with the passage of time, whereby the amplitude over a first period remains below a cavitation threshold, then, in a second period becomes higher than said cavitation threshold.
Claim 41
Dependent Claim
46 words
The apparatus according to claim 22, comprising means for displacing said treatment device in order to perform point-by-point treatment, each of said points being determined by the said focal point or region F, in order to cover the entire volume of the target to be treated.
Claim 42
Independent Claim
261 words
An apparatus for performing therapy using ultrasound, comprising at least one treatment device comprising at least one piezoelectric transducer element designed to provide at least said therapy for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, and control means for said device in order to carry out said therapy, said piezoelectric transducer element being designed to supply ultrasonic waves focused onto a focal point or region F determining the tissue zone to be submitted to said therapy, said apparatus further comprising control means for causing said treatment device to supply ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on the tissues to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissues to be treated when such tissues are exposed to said two types of ultrasonic waves and means for displacing said treatment device in order to perform point-by-point treatment, each of said points being determined by the said focal point or region F, in order to cover the entire volume of the target to be treated, wherein said displacement means of the treatment device are controlled by a control unit which includes a computer or micro-computer, the latter being provided with software managing displacement of said treatment device as a function of the volume of the target to be treated, volume data having advantageously been acquired by imaging means associated therewith having special imaging control means controlled by said control unit for translatory or rotational displacement.
Claim 43
Independent Claim
261 words
An apparatus for performing therapy using ultrasound, comprising at least one treatment device comprising at least one piezoelectric transducer element designed to provide at least said therapy for the purpose of destroying a target to be destroyed, said target including tissue which may be located inside a body of a mammal, and control means for said device in order to carry out said therapy, said piezoelectric transducer element being designed to supply ultrasonic waves focused onto a focal point or region F determining the tissue zone to be submitted to said therapy, said apparatus further comprising control means for causing said treatment device to supply ultrasonic waves of two types, thermal waves, for producing a predominantly thermal effect on the tissues to be treated, and cavitation waves, for producing a predominantly cavitation effect on said tissues to be treated when such tissues are exposed to said two types of ultrasonic waves and means for displacing said treatment device in order to perform point-by-point treatment, each of said points being determined by the said focal point or region F, in order to cover the entire volume of the target to be treated, wherein said displacement means of the treatment device are controlled by a control unit which includes a computer or micro-computer, the latter being provided with software managing displacement of said treatment device as a function of the volume of the target to be treated, volume data having advantageously been acquired by imaging means associated therewith having special imaging control means controlled by said control unit for translatory or rotational displacement.
Claim 44
Dependent Claim
65 words
The apparatus according to claim 37, wherein said control unit controls the displacement of said displacement means of said treatment device in order to carry out treatment of the tissue regions of said target which are most remote from said treatment device up to the tissue regions that are closest to said treatment device in order to improve the effectiveness of treatment of said target.
Claim 45
Dependent Claim
66 words
The apparatus according to claim 37, wherein said control means provides a latency period between treatment of two successive points on the target to be treated in order to allow said tissue being treated to relax, said latency period being between about 1 second and 15 seconds, said latency period being employed for carrying out displacement of the treatment device from one treatment point to another.
Claim 46
Dependent Claim
32 words
The apparatus according to claim 37, wherein said control unit controls displacement of said displacement means of said treatment device in a random manner while excluding points that have already been treated.
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