Patent US5527704A successfully refreshed from Google Patents.
US5527704A
Expired / Lapsed
US
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Apparatus and method for inactivating viral contaminants in body fluids
Assignee: Fenwal Inc
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Filing: 1995-05-04
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Granted: 1996-06-18
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Expires: 2015-05-04
Abstract
Abstract A method and apparatus for inactivating viruses in a body fluid. A mixture including a therapeutically effective amount of methylene blue and an amount of a body fluid is formed in a container under sterile conditions and then the container is irradiated with a light field of a suitable intensity and wavelength for activating the methylene blue for a time sufficient to inactivate viruses in the mixture. The mixture is maintained in a substantially static state within the container.
Inventors
- 👤 Ludwig Wolf, Jr.
- 👤 William Bratten
- 👤 John Foley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 18:56
CPC Classifications
C; C12; C12M; C12M37/00; A; A61; A61L; A61L2/00; A61L2/02; A61L2/08; A61L2/16; C12N; C12N7/00; C12N7/04; A61L2103/00; A61L2103/05
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
86 words
An apparatus for inactivating at least viruses in a body fluid with methylene blue comprising: a pair of light sources disposed so as to face each other with a gap therebetween, the light sources generating a light field of suitable wavelength and intensity to activate methylene blue; and a support surface in the gap on which a container containing a mixture of the body fluid and a therapeutically effective amount of methylene blue can be supported for a time sufficient to allow viruses to be inactivated.
Claim 2
Independent Claim
86 words
An apparatus for inactivating at least viruses in a body fluid with methylene blue comprising: a pair of light sources disposed so as to face each other with a gap therebetween, the light sources generating a light field of suitable wavelength and intensity to activate methylene blue; and a support surface in the gap on which a container containing a mixture of the body fluid and a therapeutically effective amount of methylene blue can be supported for a time sufficient to allow viruses to be inactivated.
Claim 3
Dependent Claim
54 words
The apparatus of claim 1 wherein the support surface comprises a transport associated with the light source and configured to transport the container enclosing the mixture of the body fluid and a therapeutically effective amount of the methylene blue along a path of travel and within the light field generated by the light sources.
Claim 4
Dependent Claim
11 words
The apparatus of claim 2 wherein the transport comprises a conveyor.
Claim 5
Dependent Claim
24 words
The apparatus of claim 2 wherein the transport can be adjusted to transport the container within the light field for varying periods of time.
Claim 6
Dependent Claim
13 words
The apparatus of claim 1 wherein the light sources comprise light emitting diodes.
Claim 7
Dependent Claim
15 words
The apparatus of claim 1 wherein the light sources comprise arrays of light emitting diodes.
Claim 8
Dependent Claim
20 words
The apparatus of claim 1 further comprising a sensor disposed to sense the amount of light delivered to the container.
Claim 9
Dependent Claim
17 words
The apparatus of claim 1 wherein the sensor senses the amount of light transmitted through the mixture.
Claim 10
Dependent Claim
43 words
The apparatus of claim 1 further comprising a sensor disposed and configured to sense light delivered to said mixture and a processor coupled to said light source and sensor, said processor configured to monitor the cumulative amount of light delivered to the mixture.
Claim 11
Independent Claim
101 words
An apparatus for use in inactivating viruses in a body fluid, comprising: a conveyor on which can be transported a container enclosing a mixture including a body fluid to be virally inactivated and a therapeutically effective amount of methylene blue; and a light source associated with said conveyor, said light source configured to generate a light field of a suitable intensity and wavelength to activate methylene blue, said conveyor configured and associated with said light source so as to convey said container within said light field for a time period of sufficient duration to allow said methylene blue to be activated.
Claim 12
Independent Claim
101 words
An apparatus for use in inactivating viruses in a body fluid, comprising: a conveyor on which can be transported a container enclosing a mixture including a body fluid to be virally inactivated and a therapeutically effective amount of methylene blue; and a light source associated with said conveyor, said light source configured to generate a light field of a suitable intensity and wavelength to activate methylene blue, said conveyor configured and associated with said light source so as to convey said container within said light field for a time period of sufficient duration to allow said methylene blue to be activated.
Claim 13
Dependent Claim
16 words
The apparatus of claim 10 wherein said light source comprises an array of light emitting diodes.
Claim 14
Dependent Claim
19 words
The apparatus of claim 11 wherein said light source comprises a plurality of successive arrays of light emitting diodes.
Claim 15
Dependent Claim
23 words
The apparatus of claim 10 further comprising a sensor associated with the light field so as to detect light delivered to the mixture.
Claim 16
Dependent Claim
24 words
The apparatus of claim 10 wherein the light field is generated by facing arrays of light emitting diodes between which the container is transported.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-06-18 | 1999-12-18 | 2000-06-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-06-18 | 2003-12-18 | 2004-06-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-06-18 | 2007-12-18 | 2008-06-18 | $7700.00 | Window Closed / Lapsed |