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US5518680A
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Tissue regeneration matrices by solid free form fabrication techniques
Assignee: Massachusetts Institute of Technology
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Filing: 1994-02-23
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Granted: 1996-05-21
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Expires: 2014-02-23
Abstract
Abstract Solid free-form techniques for making medical devices for implantation and growth of cells from polymers or polymer/inorganic composites using computer aided design are described. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The devices can incorporate inorganic particles to improve the strength of the walls forming the pores within the matrix and to provide a source of mineral for the regenerating tissue. The devices can contain tissue adhesion peptides, or can be coated with materials which reduce tissue adhesion. The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.
Inventors
- 👤 Linda G. Cima
- 👤 Michael J. Cima
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:22
CPC Classifications
B; B29; B29C; B29C64/00; B29C64/10; B29C64/165; A; A61; A61F; A61F2/00; A61F2/02; A61F2/022; A61F2/10; A61F2/105; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/0087; A61K9/0097; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/1682; A61K9/1694; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3804; A61L27/3808; A61L27/40; A61L27/50; A61L27/56; A61L27/60; B33; B33Y; B33Y10/00; B33Y70/00; B33Y70/10; B33Y80/00; A61F2/28; A61F2/30; A61F2/30756; A61F2/3094; A61F2/0077; A61F2002/0086; A61F2002/009; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30011; A61F2002/30032; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/30199; A61F2002/3028; A61F2002/30667; A61F2002/30677; A61F2/30767; A61F2002/3093; A61F2002/30932; A61F2/30942; A61F2002/30962; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0063; A61F2240/00; A61F2240/001; A61F2250/00; A61F2250/0014; A61F2250/0023; A61F2250/003; A61F2250/0031; A61F2250/0058; A61F2250/0067; A61F2310/00; A61F2310/00005; A61F2310/00359; B29K; B29K2995/00; B29K2995/0037; B29K2995/0063; B29K2995/0064
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
35 words
A method for making devices for tissue regeneration comprising forming a polymeric matrix using a solid free-form fabrication method to form sequential layers of a biocompatible polymeric matrix having interconnected pores extending throughout the matrix.
Claim 2
Independent Claim
35 words
A method for making devices for tissue regeneration comprising forming a polymeric matrix using a solid free-form fabrication method to form sequential layers of a biocompatible polymeric matrix having interconnected pores extending throughout the matrix.
Claim 3
Dependent Claim
82 words
The method of claim 1 wherein the method is three dimensional printing, comprising a) spreading a first dispersion of a biocompatible polymer or composite powder onto a bed, b) printing a layer comprising a second dispersion of biocompatible polymer or composite powder in a solvent which binds the first biocompatible polymer or composite powder to the second biocompatible polymer or composite powder at locations where it is desired to have walls, and c) repeating step b until the desired matrix is made.
Claim 4
Dependent Claim
24 words
The method of claim 2 wherein the powder is a resorbable powder selected from the group consisting of calcium phosphate, hydroxyapatite, and calcium carbonate.
Claim 5
Dependent Claim
16 words
The method of claim 2 wherein the powder size is less than 40 microns in diameter.
Claim 6
Dependent Claim
14 words
The method of claim 2 wherein the walls are less than 100 microns thick.
Claim 7
Dependent Claim
26 words
The method of claim 2 wherein the binder is a resorbable polymer selected from the group consisting of polyhydroxyacids, polyorthoesters, polyanhydrides, and copolymers and blends thereof.
Claim 8
Dependent Claim
14 words
The method of claim 2 further comprising adding a biodegradable latex to the polymer.
Claim 9
Dependent Claim
29 words
The method of claim 2 further comprising printing a solution containing surface-active agents into the regions or lines of the powder bed in between where the binder is printed.
Claim 10
Dependent Claim
23 words
The method of claim 2 further comprising modifying the surface of the polymer with a surface active agent which prevents adhesion of cells.
Claim 11
Dependent Claim
25 words
The method of claim 2, further comprising incorporating an exogenously fabricated device into the matrix by printing layers of binder around the exogenously fabricated device.
Claim 12
Dependent Claim
31 words
The method of claim 1 wherein the method is ballistic particle manufacturing or fusion deposition modeling and polymeric material is applied to a platform in layers to form a polymeric device.
Claim 13
Dependent Claim
30 words
The method of claim 1 wherein the method is selective laser sintering comprising applying polymeric particles to a platform and fusing selected area of the polymeric particles with a laser.
Claim 14
Dependent Claim
22 words
The method of claim 1 wherein the method is stereo-lithography comprising photopolymerizing selected areas of a bath of photopolymerizable prepolymer or monomers.
Claim 15
Dependent Claim
15 words
The method of claim 1 further comprising adding a bioactive agent to the polymeric material.
Claim 16
Dependent Claim
21 words
The method of claim 14 wherein the bioactive agent is added to the polymeric particles used to form the polymer layers.
Claim 17
Dependent Claim
25 words
The method of claim 14 wherein the bioactive agent is added to a solvent or binder for polymeric particles used to form the polymer layers.
Claim 18
Dependent Claim
36 words
The method of claim 16 wherein the solvent for the bioactive agent is not a solvent for the polymer, wherein three dimensional printing is used to form discrete regions of bioactive agent within a polymeric matrix.
Claim 19
Dependent Claim
30 words
The method of claim 1 further comprising incorporating a non-biodegradable material into the device to form structural elements maintaining the integrity of the device when formed of a biodegradable material.
References Cited (Backward Citations)
US4060081A
Cited
US4520821A
Cited
US4485097A
Cited
US4609551A
Cited
US4620327A
Cited
US5204055A
Cited
US5197985A
Cited
US5226914A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-05-21 | 1999-11-20 | 2000-05-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-05-21 | 2003-11-20 | 2004-05-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-05-21 | 2007-11-20 | 2008-05-21 | $7700.00 | Window Closed / Lapsed |