US5512291A
Expired / Lapsed
US
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Method of making resorbable vascular wound dressing
Assignee: Ivy Sports Medicine LLC
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Filing: 1994-08-31
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Granted: 1996-04-30
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Expires: 2014-08-31
Abstract
Abstract The present invention is related to prostheses, their methods of manufacture and methods for repairing vascular lesions using such prostheses. Natural polymers such as collagen are processed and fabricated to form tubular resorbable vascular wound dressings with unique physico-chemical and mechanical properties for repairing selected vascular segments, and for delivering therapeutic agents at selected sites within vessels and at the anastomoses.
Inventors
- 👤 Shu-Tung Li
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 18:14
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61B; A61B17/00; A61B17/11; A61F2/95; A61F2/958; A61F2/02; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2210/00; A61F2210/0004; A61F2250/00; A61F2250/0058; A61F2250/0067; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
114 words
A method of making a self-expandable resorbable vascular wound dressing for repairing a blood vessel comprising: a) forming an aqueous dispersion containing type I collagen; b) coacervating the collagen with a coacervating agent to form coacervated collagen fibers; c) placing the coacervated collagen fibers into a coaxial cylindrical mold; d) freeze drying the fibers in the mold to form a dried collagen matrix conduit; e) spraying the freeze dried collagen matrix conduit with water mist; f) compressing the water mist treated collagen matrix conduit; g) compressing the ends of the collagen matrix conduit to form an inwardly converging tapered inner diameter; and then h) crosslinking the compressed collagen matrix conduit with a crosslinking agent.
Claim 2
Independent Claim
114 words
A method of making a self-expandable resorbable vascular wound dressing for repairing a blood vessel comprising: a) forming an aqueous dispersion containing type I collagen; b) coacervating the collagen with a coacervating agent to form coacervated collagen fibers; c) placing the coacervated collagen fibers into a coaxial cylindrical mold; d) freeze drying the fibers in the mold to form a dried collagen matrix conduit; e) spraying the freeze dried collagen matrix conduit with water mist; f) compressing the water mist treated collagen matrix conduit; g) compressing the ends of the collagen matrix conduit to form an inwardly converging tapered inner diameter; and then h) crosslinking the compressed collagen matrix conduit with a crosslinking agent.
Claim 3
Dependent Claim
28 words
The method of claim 1, wherein the frustums of a right circular cone are inserted at both ends of the compressed collagen matrix conduit prior to step (g).
Claim 4
Dependent Claim
37 words
The method of claim 1, wherein the dispersion further contains medicaments including antibiotics, aspirin, coumadin, polyanionic polysaccharides, prostaglandins, plasminogen activators, urokinase, streptokinase, glycoproteins, laminin, wound healing growth factors, type II through type XII collagens, and mixtures thereof.
Claim 5
Dependent Claim
12 words
The method of claim 1, wherein the coacervating agent is a base.
Claim 6
Dependent Claim
15 words
The method of claim 1, wherein the coaxial cylindrical mold is fabricated from biocompatible materials.
Claim 7
Dependent Claim
20 words
The method of claim 1, wherein the coaxial cylindrical mold comprises a rod in the center of a hollow cylinder.
Claim 8
Dependent Claim
64 words
The method of claim 1, wherein the water mist treatment of step (e) comprises holding the water mist bottle at a distance of from about 6 to about 18 inches; spraying the water mist onto the collagen matrix for about 5 seconds to about 30 seconds while the collagen matrix is spun at a speed of from about 20 rpm to about 700 rpm.
Claim 9
Dependent Claim
31 words
The method of claim 1, wherein the compressing step of step (f) is such that the wall thickness of the compressed matrix is from about 0.1 mm to about 1.5 mm.
Claim 10
Dependent Claim
33 words
The method of claim 1, wherein the compressing step of step (g) is such that the wall thickness at the ends of the conduit is from about 0.05 mm to about 0.30 mm.
Claim 11
Dependent Claim
11 words
The method of claim 1, wherein the crosslinking agent is formaldehyde.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-30 | 1999-10-30 | 2000-04-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-30 | 2003-10-30 | 2004-04-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-30 | 2007-10-30 | 2008-04-30 | $7700.00 | Window Closed / Lapsed |