US5510105A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of autoimmune diseases with IL-2 receptor-specific cytotoxins
Assignee: Beth Israel Deaconess Medical Center
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Filing: 1994-07-08
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Granted: 1996-04-23
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Expires: 2014-07-08
Abstract
Abstract A method of treating a mammal suffering from an autoimmune disease state is provided. The method comprises administering to the mammal a cytotoxin-conjugated IL-2 receptor-specific substance during a proliferative burst of IL-2 receptor-bearing lymphocytes associated with the disease state, whereby the lymphocytes undergoing the proliferative burst are selectively killed.
Inventors
- 👤 Terry B. Strom
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 12:32
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/2866; A; A61; A61P; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61K; A61K39/00; A61K2039/505; A61K38/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
56 words
A method of treating a mammal suffering from an autoimmune disease state-producing immune response characterized by a proliferative burst of IL-2 receptor-bearing lymphocytes, said method comprising administering to said mammal during said proliferative burst, a cytotoxin linked to an IL-2 receptor-specific substance whereby said IL-2 receptor-bearing lymphocytes are killed to the exclusion of non-IL-2 receptor-bearing cells.
Claim 2
Independent Claim
56 words
A method of treating a mammal suffering from an autoimmune disease state-producing immune response characterized by a proliferative burst of IL-2 receptor-bearing lymphocytes, said method comprising administering to said mammal during said proliferative burst, a cytotoxin linked to an IL-2 receptor-specific substance whereby said IL-2 receptor-bearing lymphocytes are killed to the exclusion of non-IL-2 receptor-bearing cells.
Claim 3
Dependent Claim
11 words
The method of claim 1, wherein said cytotoxin is diphtheria toxin.
Claim 4
Dependent Claim
10 words
The method of claim 1, wherein said cytotoxin is ricin.
Claim 5
Independent Claim
18 words
The method of any one of claims 1, 2 or 3, wherein the IL-2 receptor-bearing lymphocytes are T-lymphocytes.
Claim 6
Dependent Claim
13 words
The method of claim 4, wherein the auto immune disease is multiple sclerosis.
Claim 7
Dependent Claim
13 words
The method of claim 5, wherein the IL-2 receptor specific substance is IL-2.
Claim 8
Dependent Claim
13 words
The method of claim 4, wherein the IL-2 receptor specific substance is IL-2.
Claim 9
Independent Claim
18 words
The method of any one of claims 1, 2 or 3, wherein the IL-2 receptor-bearing lymphocytes are B-lymphocytes.
Claim 10
Dependent Claim
14 words
The method of claim 8, wherein the auto immune disease is systemic lupus erythematosus.
Claim 11
Dependent Claim
14 words
The method of claim 9, wherein the IL-2 receptor specific substance is IL- 2.
Claim 12
Dependent Claim
13 words
The method of claim 8, wherein said IL,-2 receptor specific substance is IL-2.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-23 | 1999-10-23 | 2000-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-23 | 2003-10-23 | 2004-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-23 | 2007-10-23 | 2008-04-23 | $7700.00 | Window Closed / Lapsed |