US5011684A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Lysing or blocking unwanted cells with IL-2 receptor-specific binding substance
Assignee: Beth Israel Deaconess Medical Center
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Filing: 1985-09-05
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Granted: 1991-04-30
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Expires: 2005-09-05
Abstract
Abstract A method of lysing unwanted, non-malignant cells in a mammal, the cells having on their surfaces a receptor for a growth factor, and the method including administering to the mammal a cell-lysing amount of a substance characterized in that it has specific affinity for the receptor of the growth factor and has the ability to effect the lysis of the cells.
Inventors
- 👤 Terry B. Strom
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 16:55
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/2866; A; A61; A61P; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61K; A61K39/00; A61K2039/505; A61K38/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
72 words
A method of treating a mammal suffering from a nonmalignant, disease state-producing immune response characterized by a proliferative burst of lymphocytes having on their surfaces IL-2 receptors, said method comprising administering to said mammal, during said proliferative burst, a cell-lysing or IL-2 blocking amount of a monoclonal antibody to the IL-2 receptor, whereby said IL-2 receptor-bearing lymphocytes are lysed or blocked and memory T-lymphocytes and resting T-lymphocytes of said mammal are spared.
Claim 2
Independent Claim
72 words
A method of treating a mammal suffering from a nonmalignant, disease state-producing immune response characterized by a proliferative burst of lymphocytes having on their surfaces IL-2 receptors, said method comprising administering to said mammal, during said proliferative burst, a cell-lysing or IL-2 blocking amount of a monoclonal antibody to the IL-2 receptor, whereby said IL-2 receptor-bearing lymphocytes are lysed or blocked and memory T-lymphocytes and resting T-lymphocytes of said mammal are spared.
Claim 3
Dependent Claim
10 words
The method of claim 1 wherein said lymphocytes are T-lymphocytes.
Claim 4
Dependent Claim
10 words
The method of claim 1 wherein said lymphocytes are B-lymphocytes.
Claim 5
Independent Claim
60 words
A method of inhibiting the T-lymphocyte-induced rejection of an allograft in a mammal, said T-lymphocytes, in connection with said allograft rejection, undergoing a proliferative burst characterized by the presence of IL-2 receptors on the surfaces of said T-lymphocytes, said method comprising administering to said mammal, following said allograft, and during said proliferative burst, a monoclonal antibody to the IL-2 receptor.
Claim 6
Independent Claim
60 words
A method of inhibiting the T-lymphocyte-induced rejection of an allograft in a mammal, said T-lymphocytes, in connection with said allograft rejection, undergoing a proliferative burst characterized by the presence of IL-2 receptors on the surfaces of said T-lymphocytes, said method comprising administering to said mammal, following said allograft, and during said proliferative burst, a monoclonal antibody to the IL-2 receptor.
Claim 7
Dependent Claim
18 words
The method of claim 4 wherein said antibody has the ability to effect the lysis of said T-lymphocytes.
Claim 8
Dependent Claim
15 words
The method of claim 4 wherein said antibody is of the IgG or IgM isotype.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-29 | 1994-10-29 | 1995-04-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-29 | 1998-10-29 | 1999-04-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-29 | 2002-10-29 | 2003-04-30 | $7700.00 | Window Closed / Lapsed |