US5509896A
Expired / Lapsed
US
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Enhancement of thrombolysis with external ultrasound
Assignee: TRANSON A DELAWARE Corp LLC
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Filing: 1994-09-09
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Granted: 1996-04-23
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Expires: 2014-09-09
Abstract
Abstract Apparatus and methods are provided for enhancing the thrombolytic action of a thrombolytic agent and removing a thrombosis from a vascular system by introducing a select dose of thrombolytic agent proximate the thrombosis disposed within a vessel of a body and radiating the thrombosis with ultrasound generated exterior to the body to effect removal of the thrombosis in less time than the time required by activity of the selected dose of thrombolytic agent without the ultrasonic radiation of the thrombosis.
Inventors
- 👤 Robert E. Carter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 20:02
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/22; A61B17/22004; A61B17/22012; A61N; A61N7/00; A61B2017/22082; A61B2017/22084; A61B2017/22088; A61B2017/22089; A61B90/00; A61B90/39; A61B2090/3925; A61B2090/3933
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
76 words
A method for enhancing thrombolytic action of a thrombolytic agent, said method comprising the steps of: (a) injecting a thrombolytic agent proximate a thrombosis disposed in a vessel within a body; and (b) directing ultrasonic energy, generated exterior to the body, at the thrombosis with proximate thrombolytic agent, of sufficient energy to increase the thrombolytic action of the thrombolytic agent, said ultrasonic energy being less than about 100 Kz at less than about 50 watts power.
Claim 2
Independent Claim
76 words
A method for enhancing thrombolytic action of a thrombolytic agent, said method comprising the steps of: (a) injecting a thrombolytic agent proximate a thrombosis disposed in a vessel within a body; and (b) directing ultrasonic energy, generated exterior to the body, at the thrombosis with proximate thrombolytic agent, of sufficient energy to increase the thrombolytic action of the thrombolytic agent, said ultrasonic energy being less than about 100 Kz at less than about 50 watts power.
Claim 3
Dependent Claim
23 words
The method according to claim 1 wherein streptokinase is injected as the thrombolytic agent at a concentration of less than about 2,000 u/ml.
Claim 4
Dependent Claim
21 words
The method according to claim 1 wherein streptokinase is injected as the thrombolytic agent at a concentration of about 250 u/ml.
Claim 5
Dependent Claim
26 words
The method according to claim 1 wherein streptokinase is injected, as the thrombolytic agent at a concentration of between about 50 u/ml and about 2000 u/ml.
Claim 6
Dependent Claim
19 words
The method according to claim 3 wherein said ultrasonic energy is directed with a frequency of about 26 kHz.
Claim 7
Dependent Claim
19 words
The method according to claim 4 wherein said ultrasonic energy is directed with a frequency of about 26 kHz.
Claim 8
Dependent Claim
68 words
Apparatus for removal of a cardiovascular blockage, said apparatus comprising, in combination: means for introducing a thrombolytic agent proximate a cardiovascular blockage disposed in a vessel within a body; and ultrasonic means for radiating the cardiovascular blockage with proximate thrombolytic agent with a frequency of less than about 100 kHz at less and 50 watts of power, said ultrasonic means being disposed exterior to the vessel and body.
Claim 9
Dependent Claim
68 words
Apparatus for removal of a cardiovascular blockage, said apparatus comprising, in combination: means for introducing a thrombolytic agent proximate a cardiovascular blockage disposed in a vessel within a body; and ultrasonic means for radiating the cardiovascular blockage with proximate thrombolytic agent with a frequency of less than about 100 kHz at less and 50 watts of power, said ultrasonic means being disposed exterior to the vessel and body.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-23 | 1999-10-23 | 2000-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-23 | 2003-10-23 | 2004-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-23 | 2007-10-23 | 2008-04-23 | $7700.00 | Window Closed / Lapsed |