US4931038A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Complex of products for the rapid and not-invasive treatment of biliary calculosis
Assignee: Giuliani SpA
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Filing: 1987-12-02
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Granted: 1990-06-05
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Expires: 2007-12-02
Abstract
Abstract The present invention relates to a complex of products useful for the not-invasive and rapid treatment of the biliary calculosis of cholesterolic nature. It is based upon the coupling of a special apparatus generating medium-energy or medium-low-energy ultrasounds with pharmaceutical compositions based on biliary acids, capable of de-saturating bile super-saturated with cholesterol.
Inventors
- 👤 Giuliano Frigerio
- 👤 Aldo Roda
- 👤 Enrico Roda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 07:05
CPC Classifications
A; A61; A61K; A61K41/00; A61K41/0028; A61K31/00; A61K31/56; A61K31/575
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
84 words
A therapeutic system for the rapid and not-invasive treatment of biliary calculosis of cholesterolic nature and accompanying concentrations of calculi, comprising a pharmaceutical composition containing, as its active principle, a biliary acid capable of desaturating bile super-saturated in cholesterol, in combination with a low-power or medium-power ultrasound generating apparatus which generates low-energy or medium energy ultrasounds, said ultrasounds being focused on said calculi concentrations, wherein said combination of said biliary acid and said ultrasound functions to cause the efficient dissolution of said calculi concentrations.
Claim 2
Dependent Claim
84 words
A therapeutic system for the rapid and not-invasive treatment of biliary calculosis of cholesterolic nature and accompanying concentrations of calculi, comprising a pharmaceutical composition containing, as its active principle, a biliary acid capable of desaturating bile super-saturated in cholesterol, in combination with a low-power or medium-power ultrasound generating apparatus which generates low-energy or medium energy ultrasounds, said ultrasounds being focused on said calculi concentrations, wherein said combination of said biliary acid and said ultrasound functions to cause the efficient dissolution of said calculi concentrations.
Claim 3
Dependent Claim
48 words
A therapeutic system according to claim 1, wherein said ultrasound generating apparatus has a power output within the range of from 2 milliwatts/cm 2 of application surface area, to 4 watts/cm 2 of application surface area, said power output being applied to emissions pulsated every thousandth of second.
Claim 4
Dependent Claim
31 words
A therapeutic system according to claim 1, wherein said ultrasound generating apparatus is equipped with an aiming device to define the focus of application of said ultrasounds on said calculi concentrations.
Claim 5
Dependent Claim
46 words
A therapeutic system for the rapid and not invasive treatment of biliary calculosis of cholesterolic nature and accompanying concentrations of calculi, characterized in that it comprises a biliary acid, and low-energy or medium-energy ultrasounds at a dosage sufficient to cause complete dissolution of said calculi concentrations.
Claim 6
Dependent Claim
46 words
A therapeutic system for the rapid and not invasive treatment of biliary calculosis of cholesterolic nature and accompanying concentrations of calculi, characterized in that it comprises a biliary acid, and low-energy or medium-energy ultrasounds at a dosage sufficient to cause complete dissolution of said calculi concentrations.
Claim 7
Dependent Claim
31 words
A therapeutic system according to claim 1, wherein said biliary acid and said ultrasounds are periodically applied, at successive times, after each other to cause complete dissolution of said calculi concentrations.
Claim 8
Dependent Claim
31 words
A therapeutic system according to claim 1, wherein said biliary acid and said ultrasounds are periodically applied according to a prearranged sequence sufficient to cause complete dissolution of said calculi concentrations.
Claim 9
Dependent Claim
30 words
A therapeutic system according to claim 1, wherein said biliary acid and said ultrasounds are periodically applied, simultaneously to each other sufficient to cause complete dissolution of said calculi concentrations.
Claim 10
Independent Claim
82 words
A method for the rapid and not-invasive treatment of biliary calculosis comprising: administering a pharmaceutical composition containing as its active principle, a biliary acid capable of de-saturating bile super-saturated in cholesterol to a patient having biliary calculosis and accompanying concentrations of calculi; and subjecting said calculi concentrations to a dosage of low-energy or medium-energy ultrasounds sufficient to cause dissolution of said calculi concentrations, wherein said biliary acid and said ultrasound function in combination to cause the efficient dissolution of said calculi concentrations.
Claim 11
Independent Claim
82 words
A method for the rapid and not-invasive treatment of biliary calculosis comprising: administering a pharmaceutical composition containing as its active principle, a biliary acid capable of de-saturating bile super-saturated in cholesterol to a patient having biliary calculosis and accompanying concentrations of calculi; and subjecting said calculi concentrations to a dosage of low-energy or medium-energy ultrasounds sufficient to cause dissolution of said calculi concentrations, wherein said biliary acid and said ultrasound function in combination to cause the efficient dissolution of said calculi concentrations.
Claim 12
Dependent Claim
42 words
A method for the rapid and not-invasive and not-invasive treatment of biliary calculosis as claimed in claim 11, wherein said biliary acid and said ultrasounds are applied at successive intervals, after each other, sufficient to cause complete dissolution of said calculi concentrations.
Claim 13
Dependent Claim
40 words
A method for the rapid and not-invasive treatment of biliary calculosis as claimed in claim 8, wherein said biliary acid and said ultrasounds are periodically applied according to a prearranged sequence sufficient to cause complete dissolution of said calculi concentrations.
Claim 14
Dependent Claim
39 words
A method for the rapid and not-invasive treatment of biliary calculosis as claimed in claim 8, wherein said biliary acid and said ultrasounds are periodically applied simultaneously to each other sufficient to cause complete dissolution of said calculi concentrations.
Claim 15
Dependent Claim
94 words
A therapeutic system for the rapid and not-invasive treatment of biliary calculosis of cholesterolic nature and accompanying concentrations of calculi, comprising a pharmaceutical composition containing, as its active principle, a biliary acid capable of de-saturating bile super-saturated in cholesterol, selected from the group consisting of chenodeoxycholic acid and ursodeoxycholic acid, in combination with a low-power or medium-power ultrasound generating apparatus which generates low-energy or medium-energy ultrasounds, said ultrasounds being focused on said calculi concentrations, wherein said combination of said biliary acid and said ultrasounds function to cause the efficient dissolution of said calculi concentrations.
Claim 16
Dependent Claim
94 words
A therapeutic system for the rapid and not-invasive treatment of biliary calculosis of cholesterolic nature and accompanying concentrations of calculi, comprising a pharmaceutical composition containing, as its active principle, a biliary acid capable of de-saturating bile super-saturated in cholesterol, selected from the group consisting of chenodeoxycholic acid and ursodeoxycholic acid, in combination with a low-power or medium-power ultrasound generating apparatus which generates low-energy or medium-energy ultrasounds, said ultrasounds being focused on said calculi concentrations, wherein said combination of said biliary acid and said ultrasounds function to cause the efficient dissolution of said calculi concentrations.
Claim 17
Independent Claim
96 words
A method for the rapid and not-invasive treatment of biliary calculosis comprising: administering a pharmaceutical composition containing as its active principle, a biliary acid capable of de-saturating bile super-saturated in cholesterol, selected from the group consisting of chenodeoxycholic acid and ursodeoxycholic acid, to a patient having biliary calculosis and accompanying concentrations of calculi; and subjecting said calculi concentrations to a dosage of low-energy or medium energy ultrasounds sufficient to cause the efficient dissolution of said calculi concentrations, wherein said biliary acid and said ultrasound function in combination to cause the efficient dissolution of said calculi concentrations.
Claim 18
Independent Claim
96 words
A method for the rapid and not-invasive treatment of biliary calculosis comprising: administering a pharmaceutical composition containing as its active principle, a biliary acid capable of de-saturating bile super-saturated in cholesterol, selected from the group consisting of chenodeoxycholic acid and ursodeoxycholic acid, to a patient having biliary calculosis and accompanying concentrations of calculi; and subjecting said calculi concentrations to a dosage of low-energy or medium energy ultrasounds sufficient to cause the efficient dissolution of said calculi concentrations, wherein said biliary acid and said ultrasound function in combination to cause the efficient dissolution of said calculi concentrations.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-06-04 | 1993-12-04 | 1994-06-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-06-04 | 1997-12-04 | 1998-06-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-06-04 | 2001-12-04 | 2002-06-05 | $7700.00 | Window Closed / Lapsed |