US5480723A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Surface-bound fluorescent polymers and related methods of synthesis and use
Assignee: Optical Sensors Inc
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Filing: 1994-05-17
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Granted: 1996-01-02
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Expires: 2014-05-17
Abstract
Abstract A fiber optic sensing device for measuring a chemical or physiological parameter of a body fluid or tissue is provided. To one end of the fiber is attached a polymer including a plurality of photoactive moieties selected from the group consisting of chromophores and lumophores, the photoactive moieties spaced apart so as to minimize chemical or physical interaction therebetween while optimizing the density of photoactive moieties. In one embodiment, a polymer chain is covalently bound to photoactive moieties through functional groups such as esters, amides, or the like. In a second embodiment, a polymer chain is inherently fluorescent and is formed from at least one monomeric unit. These devices are particularly useful as pH and oxygen sensors.
Inventors
- 👤 Stanley M. Klainer
- 👤 David R. Walt
- 👤 Amos J. Gottlieb
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:55
CPC Classifications
C; C09; C09K; C09K11/00; C09K11/06; G; G01; G01N; G01N21/00; G01N21/62; G01N21/63; G01N21/64; G01N21/6428; G01N21/75; G01N21/77; G01N21/7703; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/551; G01N33/552; G01N2021/6432; G01N21/645; G01N2021/6484; G01N2021/7706; G01N2021/772; G01N21/78; G01N21/81; Y; Y10; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31551; Y10T428/31645; Y10T428/31855
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
43 words
A surface-bound fluorescent polymer prepared by the process comprising copolymerizing a monomeric fluorescent species having the structure ##STR18## with acrylamide in the presence of a catalyst and in the presence of a glass surface having free NH 2 groups activated with acryloyl chloride.
Claim 2
Dependent Claim
43 words
A surface-bound fluorescent polymer prepared by the process comprising copolymerizing a monomeric fluorescent species having the structure ##STR18## with acrylamide in the presence of a catalyst and in the presence of a glass surface having free NH 2 groups activated with acryloyl chloride.
Claim 3
Dependent Claim
36 words
A process for preparing a surface-bound fluorescent polymer, comprising copolymerizing a monomeric fluorescent species having the structure ##STR19## with acrylamide in the presence of a glass surface having free NH 2 groups activated with acryloyl chloride.
Claim 4
Dependent Claim
36 words
A process for preparing a surface-bound fluorescent polymer, comprising copolymerizing a monomeric fluorescent species having the structure ##STR19## with acrylamide in the presence of a glass surface having free NH 2 groups activated with acryloyl chloride.
Claim 5
Dependent Claim
141 words
A surface-bound fluorescent polymer prepared by the process comprising: (a.) treating a glass surface having free NH 2 groups with succinic anhydride, to produce acid glass in which the free NH 2 groups have been replaced with surface --NH(CO)CH 2 CH 2 COOH groups; (b.) preparing acid chloride glass by converting the surface --NH(CO)CH 2 CH 2 COOH groups to surface --NH(CO)CH 2 CH 2 COCl moieties; (c.) treating said acid chloride glass with N-hydroxysuccinimide, to produce NHS glass having surface ##STR20## groups; (d.) treating the NHS glass with triethylenetetramine, to provide aminoalkyl glass having surface ##STR21## groups; (e.) activating the aminoalkyl glass with acryloyl chloride to provide an activated surface having surface-bound acrylamide groups; and (f.) copolymerizing a fluorescent species having the structure ##STR22## with acrylamide in the presence of a catalyst and in the presence of the activated surface.
Claim 6
Dependent Claim
141 words
A surface-bound fluorescent polymer prepared by the process comprising: (a.) treating a glass surface having free NH 2 groups with succinic anhydride, to produce acid glass in which the free NH 2 groups have been replaced with surface --NH(CO)CH 2 CH 2 COOH groups; (b.) preparing acid chloride glass by converting the surface --NH(CO)CH 2 CH 2 COOH groups to surface --NH(CO)CH 2 CH 2 COCl moieties; (c.) treating said acid chloride glass with N-hydroxysuccinimide, to produce NHS glass having surface ##STR20## groups; (d.) treating the NHS glass with triethylenetetramine, to provide aminoalkyl glass having surface ##STR21## groups; (e.) activating the aminoalkyl glass with acryloyl chloride to provide an activated surface having surface-bound acrylamide groups; and (f.) copolymerizing a fluorescent species having the structure ##STR22## with acrylamide in the presence of a catalyst and in the presence of the activated surface.
Claim 7
Dependent Claim
141 words
A process for preparing a surface-bound fluorescent polymer, comprising: (a.) treating a glass surface having free NH 2 groups with succinic anhydride, to produce acid glass in which the free NH 2 groups have been replaced with surface --NH(CO)CH 2 CH 2 COOH groups; (b.) preparing acid chloride glass by converting the surface --NH(CO)CH 2 CH 2 COOH groups to surface --NH(CO)CH 2 CH 2 COCl moieties; (c.) treating said acid chloride glass with N-hydroxysuccinimide, to produce NHS glass having surface ##STR23## groups; (d.) treating the NHS glass with triethylenetetramine, to provide aminoalkyl glass having surface ##STR24## groups; (e.) activating the aminoalkyl glass with acryloyl chloride to provide an activated surface having surface-bound acrylamide groups; and (f.) copolymerizing a fluorescent species having the structure ##STR25## with acrylamide in the presence of a catalyst and in the presence of the activated surface.
Claim 8
Dependent Claim
141 words
A process for preparing a surface-bound fluorescent polymer, comprising: (a.) treating a glass surface having free NH 2 groups with succinic anhydride, to produce acid glass in which the free NH 2 groups have been replaced with surface --NH(CO)CH 2 CH 2 COOH groups; (b.) preparing acid chloride glass by converting the surface --NH(CO)CH 2 CH 2 COOH groups to surface --NH(CO)CH 2 CH 2 COCl moieties; (c.) treating said acid chloride glass with N-hydroxysuccinimide, to produce NHS glass having surface ##STR23## groups; (d.) treating the NHS glass with triethylenetetramine, to provide aminoalkyl glass having surface ##STR24## groups; (e.) activating the aminoalkyl glass with acryloyl chloride to provide an activated surface having surface-bound acrylamide groups; and (f.) copolymerizing a fluorescent species having the structure ##STR25## with acrylamide in the presence of a catalyst and in the presence of the activated surface.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-01-01 | 1999-07-03 | 2000-01-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-01-01 | 2003-07-03 | 2004-01-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-01-01 | 2007-07-03 | 2008-01-02 | $7700.00 | Window Closed / Lapsed |