Patent US5476094A successfully refreshed from Google Patents.
US5476094A
Expired / Lapsed
US
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Acrylic copolymer membranes for biosensors
Assignee: Tecpharma Licensing AG
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Filing: 1993-11-15
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Granted: 1995-12-19
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Expires: 2013-11-15
Abstract
Abstract Homogeneous membranes are disclosed which are composed of acrylic copolymers and are capable of absorbing 10% to 50% of their dry weight of water. The copolymers include a hydrophilic component which comprises acrylic esters having a poly(ethylene oxide) substituent as part of the alcohol moiety. The copolymers further comprise methacrylate and/or acrylate monomer units. The membranes are useful in the fabrication of biosensors, e.g., a glucose sensor, intended for in vivo use. Variations in the ratios of the monomeric components make possible the fabrication of membranes which have varying permeabilities.
Inventors
- 👤 Douglas J. Allen
- 👤 Robert S. Nevin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 06:28
CPC Classifications
B; B01; B01D; B01D71/00; B01D71/06; B01D71/76; B01D71/40; B01D71/401; B01D71/4011; B01D71/52; B01D71/521; B01D71/5211; C; C12; C12Q; C12Q1/00; C12Q1/001; C12Q1/002; C12Q1/005; C12Q1/006; B01D2325/00; B01D2325/34
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
78 words
A homogeneous membrane adapted for use on a biosensor having sensor elements for evaluating the presence of an analyte, said membrane being for enclosing the sensor elements, said membrane comprising: an acrylic copolymer including first monomer units consisting of an acrylic ester having a poly(ethylene oxide) substituent as part of the alcohol moiety, and second monomer units selected from methacrylates, acrylates and combinations thereof, said membrane absorbing about 10% to about 50% of its dry weight of water.
Claim 2
Dependent Claim
78 words
A homogeneous membrane adapted for use on a biosensor having sensor elements for evaluating the presence of an analyte, said membrane being for enclosing the sensor elements, said membrane comprising: an acrylic copolymer including first monomer units consisting of an acrylic ester having a poly(ethylene oxide) substituent as part of the alcohol moiety, and second monomer units selected from methacrylates, acrylates and combinations thereof, said membrane absorbing about 10% to about 50% of its dry weight of water.
Claim 3
Dependent Claim
14 words
The membrane of claim 1 in which said second monomer units comprise methyl methacrylate.
Claim 4
Dependent Claim
14 words
The membrane of claim 1 in which said second monomer units comprise ethyl acrylate.
Claim 5
Dependent Claim
15 words
The membrane of claim 3 in which said second monomer units further comprise methyl methacrylate.
Claim 6
Dependent Claim
21 words
The membrane of claim 1 in which said membrane absorbs about 15% to about 25% of its dry weight of water.
Claim 7
Dependent Claim
23 words
The membrane of claim 1 in which the poly(ethylene oxide) substituent has an average molecular weight of from about 200 to about 2000.
Claim 8
Dependent Claim
21 words
The membrane of claim 6 in which said membrane absorbs about 15% to about 25% of its dry weight of water.
Claim 9
Dependent Claim
19 words
The membrane of claim 6 in which the poly(ethylene oxide) substituent has an average molecular weight of about 1000.
Claim 10
Dependent Claim
16 words
The membrane of claim 8 in which said poly(ethylene oxide) substituent comprises methoxy poly(ethylene oxide) methacrylate.
Claim 11
Dependent Claim
43 words
The membrane of claim 1 in which said membrane is adapted for use on an electrochemical glucose sensor, and in which said membrane has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of up to about 4000.
Claim 12
Dependent Claim
21 words
The membrane of claim 10 in which said composition absorbs about 15% to about 25% of its dry weight of water.
Claim 13
Dependent Claim
23 words
The membrane of claim 10 in which the poly(ethylene oxide) substituent has an average molecular weight of from about 200 to about 2000.
Claim 14
Dependent Claim
19 words
The membrane of claim 10 in which the diffusion ratio for said composition is about 2500 to about 3500.
Claim 15
Dependent Claim
21 words
The membrane of claim 13 in which said membrane absorbs about 15% to about 25% of its dry weight of water.
Claim 16
Dependent Claim
23 words
The membrane of claim 13 in which the poly(ethylene oxide) substituent has an average molecular weight of from about 200 to about 2000.
Claim 17
Dependent Claim
21 words
The membrane of claim 15 in which said membrane absorbs about 15% to about 25% of its dry weight of water.
Claim 18
Dependent Claim
116 words
In an implantable device for determining the level of an analyte in a body, said device comprising a biosensor having sensor elements for evaluating the presence of the analyte and including a membrane enclosing the sensor elements, said membrane providing biocompatibility, protection of the sensor elements from the surrounding biological environment, and control of diffusion of materials to the sensor elements, the improvement comprising forming said membrane from an acrylic copolymer comprising first monomer units consisting of an acrylic ester having a poly(ethylene oxide) substituent as part of the alcohol moiety, and second monomer units selected from methacrylates, acrylates and combinations thereof, said membrane absorbing about 10% to about 50% of its dry weight of water.
Claim 19
Dependent Claim
116 words
In an implantable device for determining the level of an analyte in a body, said device comprising a biosensor having sensor elements for evaluating the presence of the analyte and including a membrane enclosing the sensor elements, said membrane providing biocompatibility, protection of the sensor elements from the surrounding biological environment, and control of diffusion of materials to the sensor elements, the improvement comprising forming said membrane from an acrylic copolymer comprising first monomer units consisting of an acrylic ester having a poly(ethylene oxide) substituent as part of the alcohol moiety, and second monomer units selected from methacrylates, acrylates and combinations thereof, said membrane absorbing about 10% to about 50% of its dry weight of water.
Claim 20
Dependent Claim
14 words
The improvement of claim 17 in which said second monomer units comprise methyl methacrylate.
Claim 21
Dependent Claim
14 words
The improvement of claim 17 in which said second monomer units comprise ethyl acrylate.
Claim 22
Dependent Claim
15 words
The improvement of claim 19 in which said second monomer units further comprise methyl methacrylate.
Claim 23
Dependent Claim
21 words
The improvement of claim 17 in which said membrane absorbs about 15% to about 25% of its dry weight of water.
Claim 24
Dependent Claim
23 words
The improvement of claim 17 in which the poly(ethylene oxide) substituent has an average molecular weight of from about 200 to about 2000.
Claim 25
Dependent Claim
19 words
The improvement of claim 22 in which the poly(ethylene oxide) substituent has an average molecular weight of about 1000.
Claim 26
Dependent Claim
49 words
The improvement of claim 17 in which said biosensor is an electrochemical glucose sensor, said membrane controlling the diffusion of oxygen and glucose to the sensor elements, said membrane having a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of up to about 4000.
Claim 27
Dependent Claim
19 words
The membrane of claim 24 in which the diffusion ratio for said composition is about 2500 to about 3500.
Claim 28
Dependent Claim
21 words
The membrane of claim 24 in which said composition absorbs about 15% to about 25% of its dry weight of water.
Claim 29
Dependent Claim
23 words
The membrane of claim 24 in which the poly(ethylene oxide) substituent has an average molecular weight of from about 200 to about 2000.
Claim 30
Dependent Claim
19 words
The membrane of claim 27 in which the poly(ethylene oxide) substituent has an average molecular weight of about 1000.
Claim 31
Dependent Claim
14 words
The membrane of claim 24 in which said second monomer units comprise methyl methacrylate.
Claim 32
Dependent Claim
14 words
The membrane of claim 24 in which said second monomer units comprise ethyl acrylate.
Claim 33
Dependent Claim
14 words
The membrane of claim 30 in which said second monomer units comprise methyl methacrylate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-12-18 | 1999-06-19 | 1999-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-12-18 | 2003-06-19 | 2003-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-12-18 | 2007-06-19 | 2007-12-19 | $7700.00 | Window Closed / Lapsed |