US5284140A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Acrylic copolymer membranes for biosensors
Assignee: Tecpharma Licensing AG
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Filing: 1992-02-11
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Granted: 1994-02-08
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Expires: 2012-02-11
Abstract
Abstract Homogeneous membranes are disclosed which are composed of acrylic copolymers and are capable of absorbing 10% to 50% of their dry weight of water. The copolymers include a hydrophilic component which comprises acrylic esters having a poly(ethylene oxide) substituent as part of the alcohol moiety. The copolymers further comprise methacrylate and/or acrylate monomer units. The membranes are useful in the fabrication of biosensors, e.g., a glucose sensor, intended for in vivo use. Variations in the ratios of the monomeric components make possible the fabrication of membranes which have varying permeabilities.
Inventors
- 👤 Douglas J. Allen
- 👤 Robert S. Nevin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 05:05
CPC Classifications
B; B01; B01D; B01D71/00; B01D71/06; B01D71/76; B01D71/40; B01D71/401; B01D71/4011; B01D71/52; B01D71/521; B01D71/5211; C; C12; C12Q; C12Q1/00; C12Q1/001; C12Q1/002; C12Q1/005; C12Q1/006; B01D2325/00; B01D2325/34
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
122 words
In an implatable device for determining the level of an anlyte in a body, said device comprising a biosensor having sensor elements for evaluating the presence of the analyte and including a membrane enclosing the sensor elements, said membrane providing biocompatibility, protection of the sensor elements from the surrounding biological environment, and control of diffusion of materials to the sensor elements, the improvement comprising forming said membrane from an acrylic copolymer comprising first monomer units consisting of an acrylic ester having methoxy poly(ethylene oxide) methacrylate as part of the alcohol moiety, and second monomer units selected from methacrylates, acrylates and combinations thereof, said membrane absorbing water in an amount of about 10% to about 50% of the dry weight of said membrane.
Claim 2
Dependent Claim
122 words
In an implatable device for determining the level of an anlyte in a body, said device comprising a biosensor having sensor elements for evaluating the presence of the analyte and including a membrane enclosing the sensor elements, said membrane providing biocompatibility, protection of the sensor elements from the surrounding biological environment, and control of diffusion of materials to the sensor elements, the improvement comprising forming said membrane from an acrylic copolymer comprising first monomer units consisting of an acrylic ester having methoxy poly(ethylene oxide) methacrylate as part of the alcohol moiety, and second monomer units selected from methacrylates, acrylates and combinations thereof, said membrane absorbing water in an amount of about 10% to about 50% of the dry weight of said membrane.
Claim 3
Dependent Claim
14 words
The improvement of claim 1 in which said second monomer units comprise methyl methacrylate.
Claim 4
Dependent Claim
14 words
The improvement of claim 1 in which said second monomer units comprise ethyl acrylate.
Claim 5
Dependent Claim
15 words
The improvement of claim 3 in which said second monomer units further comprise methyl methacrylate.
Claim 6
Dependent Claim
24 words
The improvement of claim 1 in which said membrane absorbs water in an amount of about 15% to about 25% of its dry weight.
Claim 7
Dependent Claim
24 words
The improvement of claim 1 in which the methoxy poly(ethylene oxide) methacrylate has an average molecular weight of from about 200 to about 2000.
Claim 8
Dependent Claim
20 words
The improvement of claim 6 in which the methoxy poly(ethylene oxide) methacrylate has an average molecular weight of about 1000.
Claim 9
Dependent Claim
29 words
The improvement of claim 1 in which said membrane has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of up to about 4000.
Claim 10
Dependent Claim
19 words
The improvement of claim 8 in which the diffusion ratio for the membrane is about 2500 to about 3500.
Claim 11
Dependent Claim
19 words
The improvement of claim 8 in which said composition absorbs about 15% to about 25% of its dry weight.
Claim 12
Dependent Claim
24 words
The improvement of claim 8 in which the methoxy poly(ethylene oxide) methacrylate has an average molecular weight of from about 200 to about 2000.
Claim 13
Dependent Claim
20 words
The improvement of claim 11 in which the methoxy poly(ethylene oxide) methacrylate has an average molecular weight of about 1000.
Claim 14
Dependent Claim
14 words
The improvement of claim 8 in which said second monomer units comprise methyl methacrylate.
Claim 15
Dependent Claim
14 words
The improvement of claim 8 in which said second monomer units comprise ethyl acrylate.
Claim 16
Dependent Claim
14 words
The improvement of claim 14 in which said second monomer units comprise methyl methacrylate.
References Cited (Backward Citations)
US3220960A
Cited
US3912614A
Cited
EP0068509A2
Cited
US4484987A
Cited
US5030333A
Cited
US4890620A
Cited
US4759828A
Cited
EP0309214A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-02-07 | 1997-08-09 | 1998-02-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-02-07 | 2001-08-09 | 2002-02-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-02-07 | 2005-08-09 | 2006-02-08 | $7700.00 | Window Closed / Lapsed |