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US5451408A
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US
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Pain management with liposome-encapsulated analgesic drugs
Assignee: EASTERN TECHNOLOGY SEED INVESTMENT FUND LP
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Filing: 1994-03-23
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Granted: 1995-09-19
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Expires: 2014-03-23
Abstract
Abstract Liposome-encapsulated opioid analgesic agents delivered by the pulmonary route provide local, or systemic analgesia superior to that produced by the solution form of these agents administered by parentral (intravenous, intramuscular, or subcutaneous injection) or oral routes.
Inventors
- 👤 Michael Mezei
- 👤 Orlando Rung
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 12:35
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/007; A61K9/0073; A61K9/0078; A61K31/00; A61K31/13; A61K31/135; A61K31/33; A61K31/395; A61K31/435; A61K31/439; A61K31/44; A61K31/445; A61K31/4468; A61K31/47; A61K31/485; A61K9/10; A61K9/127
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
26 words
A method of managing pain in a patient comprising administering to said patient a composition containing a liposome-encapsulated opioid analgesic agent through said patient's pulmonary system.
Claim 2
Independent Claim
26 words
A method of managing pain in a patient comprising administering to said patient a composition containing a liposome-encapsulated opioid analgesic agent through said patient's pulmonary system.
Claim 3
Dependent Claim
16 words
The method of claim 1 in which the liposome-encapsulated opioid analgesic agent comprises multilamellar lipid vesicles.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein the liposome-encapsulated opioid analgesic agent comprises unilamellar lipid vesicles.
Claim 5
Dependent Claim
13 words
The method of claim 1 wherein the liposome-encapsulated opioid analgesic agent is multivesicular.
Claim 6
Dependent Claim
16 words
The method of claim 1 wherein the liposome-encapsulated opioid analgesic agent comprises a multiphase liposomal system.
Claim 7
Dependent Claim
16 words
The method of claim 1 wherein the liposome-encapsulated opioid analgesic agent is prepared using a phospholipid.
Claim 8
Dependent Claim
23 words
The method of claim 6 wherein said phospholipid is selected from the groups consisting of phosphatidylcholines, lysophosphatidylcholines, phosphatidylserines, phosphatidylethanolamines, phosphatidylinositols and mixtures thereof.
Claim 9
Dependent Claim
31 words
The method of claim 6 wherein said phospholipid is provided in admixtures with a modifying agent selected from the group consisting of cholesterols, stearyl amines, stearic acid, tocopherols, and mixtures thereof.
Claim 10
Dependent Claim
34 words
The method of claim 8 wherein said opioid analgesic agent is selected from the group consisting of alfentanil, anileridine, codiene, diamorphine, fentanyl, hydrocodone, hydromorphone, meperidine (pethidine), morphine, oxycodone, oxymorphone, propoxyphene, sufentanil, pentazocine and nalbuphine.
Claim 11
Dependent Claim
21 words
The method of claim 1 wherein the composition contains said opioid in an amount of between 0.005% to 10% by weight.
Claim 12
Independent Claim
23 words
A method for providing systemic analgesia in a patient by administering a liposomal-encapsulated opioid analgesic agent by inhalation through said patient's pulmonary system.
Claim 13
Independent Claim
23 words
A method for providing systemic analgesia in a patient by administering a liposomal-encapsulated opioid analgesic agent by inhalation through said patient's pulmonary system.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-09-18 | 1999-03-20 | 1999-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-09-18 | 2003-03-20 | 2003-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-09-18 | 2007-03-20 | 2007-09-19 | $7700.00 | Window Closed / Lapsed |