US4937078A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Liposomal local anesthetic and analgesic products
Assignee: LIPODERM PHARMACEUTICALS Inc
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Filing: 1988-08-26
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Granted: 1990-06-26
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Expires: 2008-08-26
Abstract
Abstract Liposome encapsulated local anesthetic or analgesic agents when applied to skin or mucous membranes provided greater local anesthesia and analgesia than the same agents incorporated in conventional vehicles i.e., ointment, cream or lotion.
Inventors
- 👤 Michael Mezei
- 👤 Adrienn Gesztes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 06:42
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
81 words
A method for providing local anesthesia or analgesia to a mammal which comprises topically applying a composition to said mammal in an amount of between about 0.005 to 0.5 g/cm 2 of surface to be anesthesized, said composition containing an anesthetic or analgesic agent selected from the group consisting of benzocaine, xylocaine, ketocaine, methyl salicylate, trolamine salicylate, lidocaine, prilocaine, tetracaine, pramoxine and dibucaine, encapsulated within lipid vesicles in an amount of between about 0.1 to 10% by wt. of said composition.
Claim 2
Independent Claim
81 words
A method for providing local anesthesia or analgesia to a mammal which comprises topically applying a composition to said mammal in an amount of between about 0.005 to 0.5 g/cm 2 of surface to be anesthesized, said composition containing an anesthetic or analgesic agent selected from the group consisting of benzocaine, xylocaine, ketocaine, methyl salicylate, trolamine salicylate, lidocaine, prilocaine, tetracaine, pramoxine and dibucaine, encapsulated within lipid vesicles in an amount of between about 0.1 to 10% by wt. of said composition.
Claim 3
Dependent Claim
13 words
The method of claim 1 in which the composition contains multilamellar lipid vesicles.
Claim 4
Dependent Claim
13 words
The method of claim 1 wherein the lipid vesicles comprise unilamellar lipid vesicles.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein the lipid vesicles are multivesicular.
Claim 6
Dependent Claim
14 words
The method of claim 1 wherein said lipid vesicles are prepared using a phospholipid.
Claim 7
Dependent Claim
21 words
The method of claim 5 wherein the phospholipid is selected from the group consisting of phosphatidylchloines, lysophosphatidylchloines, phosphatidylserines, phosphatidylethanolamines, and phosphatidylinositols.
Claim 8
Dependent Claim
26 words
The method of claim 6 wherein the phospholipid is provided in admixture with a modifying agent selected from the group consisting of cholesterols, stearylamines and tocopherols.
Claim 9
Dependent Claim
26 words
The method of claim 7 wherein the anesthestic or analgesic agent is selected from the group consisting of benzocaine, xylocaine, ketocaine, lidocaine, prilocaine, tetracaine and dibucaine.
Claim 10
Dependent Claim
24 words
The method of claim 8 wherein the composition contains said anesthestic or analgesic agent in an amount between about 0.3% and 5.0% by weight.
Claim 11
Dependent Claim
47 words
A pharmaceutical composition comprising lipid vesicles having a topical anesthetic or analgesic agent selected from the group consisting of benzocane, xylocaine, ketocaine, methyl salicylate, trolamine salicylate, lidocaine, prilocaine, tetracaine and pramoxine, encapsulated therein in an amount of between about 0.1 to 10% by wt. of said composition.
Claim 12
Dependent Claim
47 words
A pharmaceutical composition comprising lipid vesicles having a topical anesthetic or analgesic agent selected from the group consisting of benzocane, xylocaine, ketocaine, methyl salicylate, trolamine salicylate, lidocaine, prilocaine, tetracaine and pramoxine, encapsulated therein in an amount of between about 0.1 to 10% by wt. of said composition.
Claim 13
Dependent Claim
11 words
The composition of claim 10 wherein the lipid vesicles are multilamellar.
Claim 14
Dependent Claim
11 words
The composition of claim 10 wherein the lipid vesicles are unilamellar.
Claim 15
Dependent Claim
11 words
The composition of claim 10 wherein the lipid vesicles are multivesicular.
Claim 16
Independent Claim
55 words
A method for providing local anesthesia or analgesia to a mammal which comprises topically applying to said mammal a composition containing phospholipid vesicles encapsulating 0.1 to 10% by wt. of an anesthetic or analgesic agent, wherein said composition is applied in an amount between about 0.005 to 0.5 g/cm 2 of surface to be anesthesized.
Claim 17
Independent Claim
55 words
A method for providing local anesthesia or analgesia to a mammal which comprises topically applying to said mammal a composition containing phospholipid vesicles encapsulating 0.1 to 10% by wt. of an anesthetic or analgesic agent, wherein said composition is applied in an amount between about 0.005 to 0.5 g/cm 2 of surface to be anesthesized.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-06-25 | 1993-12-25 | 1994-06-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-06-25 | 1997-12-25 | 1998-06-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-06-25 | 2001-12-25 | 2002-06-26 | $7700.00 | Window Closed / Lapsed |