US4048310A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Topical steroid formulation in form of lotion or cream
Assignee: ER Squibb and Sons LLC
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Filing: 1976-02-24
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Granted: 1977-09-13
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Expires: 1996-02-24
Abstract
Abstract Steroid formulations in the form of creams or lotions which are used as topical anti-inflammatory agents are provided wherein the steroid, such as 21-chloro-9α-fluoro-Δ 4 -pregnene-11β,16α,17α-triol-3,20-dione 16,17-acetonide, is at least partially dissolved in a ricinoleate vehicle such as castor oil.
Inventors
- 👤 James Ling Chen
- 👤 Jean M. Battaglia
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 18:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K31/00; A61K31/56; A61K31/57
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
73 words
A composition for topical application in the form of a cream or lotion, comprising at least one steroid wherein said steroid is selected from the group consisting of 21-chloro-9α-fluoro-Δ 4 -pregnene-11β, 16α,17α-triol-3,20-dione 16,17-acetonide; 21-chloro-9-fluoro-2',3'-dihydro-11β-hydroxy-5'-propylpregna-1,4-dieno[16α,17-b][1,4]-dioxin-3,20-dione:dichloro methane solvate (1:1); and 9α-fluoro-11β, 16α,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione 16,17-acetonide, a ricinoleate vehicle in which said steroid is at least partially soluble, an emulsifier-thickener comprising a polyethylene glycol ether of a fatty alcohol, an oleaginous material or emollient, a preservative and water.
Claim 2
Dependent Claim
73 words
A composition for topical application in the form of a cream or lotion, comprising at least one steroid wherein said steroid is selected from the group consisting of 21-chloro-9α-fluoro-Δ 4 -pregnene-11β, 16α,17α-triol-3,20-dione 16,17-acetonide; 21-chloro-9-fluoro-2',3'-dihydro-11β-hydroxy-5'-propylpregna-1,4-dieno[16α,17-b][1,4]-dioxin-3,20-dione:dichloro methane solvate (1:1); and 9α-fluoro-11β, 16α,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione 16,17-acetonide, a ricinoleate vehicle in which said steroid is at least partially soluble, an emulsifier-thickener comprising a polyethylene glycol ether of a fatty alcohol, an oleaginous material or emollient, a preservative and water.
Claim 3
Dependent Claim
14 words
The composition as defined in claim 1 wherein said ricinoleate vehicle is castor oil.
Claim 4
Dependent Claim
143 words
The composition as defined in claim 1 wherein said steroid is present in an amount within the range of from about 0.005 to about 0.6% by weight of the composition said ricinoleate vehicle is present in an amount within the range of from about 0.5 to about 2% by weight of the composition, said emulsifier-thickener is present in an amount within the range of from about 1 to about 14% by weight of the composition, said oleaginous material or emollient is present in an amount within the range of from about 0.2 to about 8% by weight of the composition, said preservative is present in an amount within the range of from about 8 to about 50% by weight of the composition, and said water is present in an amount within the range of from about 30 to about 90% by weight water.
Claim 5
Dependent Claim
13 words
The composition as defined in claim 3 further including one or more antioxidants.
Claim 6
Dependent Claim
155 words
A composition as defined in claim 1 in the form of a cream wherein said steroid is all-in-solution, and said steroid is present in an amount within the range of from about 0.005 to about 0.6% by weight of the composition, said ricinoleate is present in an amount within the range of from about 0.5 to about 16% by weight of the composition, said emulsifier-thickener is present in an amount within the range of from about 5 to about 14% by weight of the composition, said oleaginous material or emollient is present in an amount within the range of from about 2 to about 8% by weight of the composition, said preservative is present in an amount within the range of from about 10 to about 50% by weight of the composition, and said water is present in an amount within the range of from about 30 to about 70% by weight of the compostion.
Claim 7
Dependent Claim
14 words
The composition as defined in claim 4 wherein said ricinoleate vehicle is castor oil.
Claim 8
Dependent Claim
154 words
A composition as defined in claim 1 in the form of a cream of the biphasic type, wherein said steroid is present in an amount within the range of from about 0.005 to about 0.6% by weight of the composition, said ricinoleate is present in an amount within the range of from about 0.5 to about 14% by weight of the composition, said emulsifier-thickener is present in an amount within the range of from about 8 to about 12% by weight of the composition, said oleaginous material or emollient is present in an amount within the range of from about 2 to about 8% by weight of the composition, said preservative is present in an amount within the range of from about 10 to about 50% by weight of the composition, and said water is present in an amount within the range of from about 30 to about 70% by weight of the composition.
Claim 9
Dependent Claim
14 words
The composition as defined in claim 7 wherein said ricinoleate vehicle is castor oil.
Claim 10
Dependent Claim
155 words
A composition as defined in claim 1 in the form of a lotion wherein said steroid is all-in-solution, said steroid is present in an amount within the range of from about 0.005 to about 0.6 % by weight of the composition, said ricinoleate is present in an amount within the range of from about 0.5 to about 16% by weight of the composition, said emulsifier-thickener is present in an amount within the range of from about 5 to about 14% by weight of the composition, aid oleaginous material or emollient is present in an amount within the range of from about 0.5 to about 6% by weight of the composition, said preservative is present in an amount within the range of from about 1 to about 50% by weight of the composition, and said water is present in an amount within the range of from about 50 to about 90% by weight of the compostion.
Claim 11
Dependent Claim
14 words
The composition as defined in claim 9 wherein said ricinoleate vehicle is castor oil.
Claim 12
Dependent Claim
154 words
A composition as defined in claim 1 in the form of a lotion of the biphasic type, wherein said steroid is present in an amount within the range of from about 0.005 to about 0.6% by weight of the composition, said ricinoleate is present in an amount within the range of from about 0.5 to about 14% by weight of the composition, said emulsifier-thickener is present in an amount within the range of from about 1 to about 5% by weight of the composition, said oleaginous material or emollient is present in an amount within the range of from about 0.2 to about 5% by weight of the composition, said preservative is present in an amount within the range of from about 8 to about 50% by weight of the composition, and said water is present in an amount within the range of from about 50 to about 90% by weight of the composition.
Claim 13
Dependent Claim
14 words
The composition as defined in claim 11 wherein said ricinoleate vehicle is castor oil.
Claim 14
Dependent Claim
17 words
A composition as defined in claim 1 wherein said steroid comprises 21-chloro-9α-fluoro-Δ 4 -pregnene-11β, 16α, 17α-triol-3,20-dione 16.17-acetonide.
Claim 15
Dependent Claim
13 words
A composition as defined in claim 1 wherein said steroid comprises 9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16.17-acetonide.
Claim 16
Dependent Claim
27 words
A composition as defined in claim 1 wherein aid oleaginous material is petrolatum, said emulsifier-thickener is polyethylene glycol fatty alcohol ether, and said preservative is propylene glycol.
Claim 17
Dependent Claim
16 words
A composition as defined in claim 1 further including econazole, nystatin, neomycin, gramicidin or mixtures thereof.
Claim 18
Dependent Claim
12 words
A composition as defined in claim 1 further including nystatin or econazole.
Claim 19
Dependent Claim
15 words
A composition as defined in claim 1 wherein said steroid comprises 21-chloro-9-fluoro-2',3'-dihydro-11β-hydroxy-5'-phenylpregna-1,4-dieno[16α,17-b][1,4]dioxin-3,20-dione:dichloro methane solvate (1:1).
Claim 20
Dependent Claim
20 words
A method of treating dermatitis, which comprises administering topically an effecttive amount of a composition as defined in claim 1.
Claim 21
Dependent Claim
20 words
A method of treating dermatitis, which comprises administering topically an effective amount of a composition as defined in claim 3.
Claim 22
Dependent Claim
20 words
A method of treating dermatitis, which comprises administering topically an effective amount of a composition as defined in claim 5.
Claim 23
Dependent Claim
20 words
A method of treating dermatitis, which comprises administering topically an effective amount of a composition as defined in claim 7.
Claim 24
Dependent Claim
20 words
A method of treating dermatitis, which comprises administering topically an effective amount of a composition as defined in claim 9.
Claim 25
Dependent Claim
20 words
A method of treating dermatitis, which comprises administering topically an effective amount of a composition as defined in claim 11.
Claim 26
Dependent Claim
12 words
The composition as defined in claim 1 further including propylene glycol monostearate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-09-12 | 1981-03-14 | 1981-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-09-12 | 1985-03-14 | 1985-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-09-12 | 1989-03-14 | 1989-09-13 | $7700.00 | Window Closed / Lapsed |