Patent US5421983A successfully refreshed from Google Patents.
US5421983A
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Anion selective electrodes containing fumed silica
Assignee: Siemens Healthcare Diagnostics Inc
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Filing: 1993-11-12
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Granted: 1995-06-06
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Expires: 2013-11-12
Abstract
Abstract This invention relates to enhanced selectivity anion membrane electrodes useful in determining the amount of an anion of interest in a biological sample. The enhanced selectivity anion membrane formulation contains fumed silica, a polymer material, and an anion selective agent. The presence of fumed silica surprisingly minimizes or reduces the effect of interfering substances, such as salicylate which may be present in biological samples and which interfere with the determination of various anions of interest, such as chloride (Cl31).
Inventors
- 👤 Lyle H. Slack
- 👤 Larry E. Snyder
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 17:18
CPC Classifications
G; G01; G01N; G01N27/00; G01N27/26; G01N27/28; G01N27/30; G01N27/333; G01N27/3335
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
46 words
An anion-selective membrane electrode for determining an anion in a biological sample which comprises an electrical conductor and an anion selective membrane wherein the membrane comprises: (a) a polymer material; (b) an anion-selective agent; and (c) from about 5% to about 50% by weight fumed silica.
Claim 2
Dependent Claim
46 words
An anion-selective membrane electrode for determining an anion in a biological sample which comprises an electrical conductor and an anion selective membrane wherein the membrane comprises: (a) a polymer material; (b) an anion-selective agent; and (c) from about 5% to about 50% by weight fumed silica.
Claim 3
Dependent Claim
48 words
The anion-selective membrane electrode of claim 1 wherein the polymer material is selected from the group consisting of polymethyl acrylate and other acrylates, silicone rubbers, polycarbonate cellulose, cellulose ester, poly(vinyl acetate), polyurethane and other urethanes, poly(vinyl butyral), polyvinyl chloride, carboxylated polyvinyl chloride, and other copolymers of vinyl chloride.
Claim 4
Dependent Claim
45 words
A chloride selective membrane electrode for determining chloride in a biological sample which comprises an electrical conductor and an anion selective membrane wherein the membrane comprises: (a) a polymer; (b) an anion-selective agent; and (c) from about 5% to about 50% by weight fumed silica.
Claim 5
Dependent Claim
45 words
A chloride selective membrane electrode for determining chloride in a biological sample which comprises an electrical conductor and an anion selective membrane wherein the membrane comprises: (a) a polymer; (b) an anion-selective agent; and (c) from about 5% to about 50% by weight fumed silica.
Claim 6
Dependent Claim
49 words
The chloride selective membrane electrode of claim 3 wherein the polymer material is selected from the group consisting of polymethyl acrylate and other acrylates, silicone rubbers, polycarbonate cellulose, cellulose ester, poly(vinyl acetate), polyurethane and other urethanes, poly(vinyl butyral), polyvinyl chloride, carboxylated polyvinyl chloride, and other copolymers of vinyl chloride.
Claim 7
Dependent Claim
25 words
The chloride selective membrane electrode of claim 3 wherein the chloride selective agent is selected from the group consisting of tridodecylmethylammonium chloride and Aliquat 336.
Claim 8
Dependent Claim
49 words
A chloride selective membrane electrode for determining chloride in a biological sample which comprises an electrical conductor and an anion selective membrane wherein the membrane comprises: (a) about 20% by weight carboxylated polyvinyl chloride; (b) about 40% by weight tridodecylmethylammonium chloride; and (c) about 40% by weight fumed silica.
Claim 9
Dependent Claim
49 words
A chloride selective membrane electrode for determining chloride in a biological sample which comprises an electrical conductor and an anion selective membrane wherein the membrane comprises: (a) about 20% by weight carboxylated polyvinyl chloride; (b) about 40% by weight tridodecylmethylammonium chloride; and (c) about 40% by weight fumed silica.
Claim 10
Dependent Claim
25 words
The anion selective membrane electrode of claims 1, 3, or 6 wherein the electrical conductor is positioned on a surface of an electrically insulative substrate.
Claim 11
Dependent Claim
13 words
The anion selective membrane electrode of claim 7 wherein the substrate is ceramic.
Claim 12
Dependent Claim
12 words
The multisensor cell assembly of claim 8 wherein the substrate is ceramic.
Claim 13
Dependent Claim
27 words
The multisensor cell assembly of claim 9 wherein the three ion selective electrodes are a potassium selective electrode, a sodium selective electrode, and a chloride selective electrode.
Claim 14
Dependent Claim
14 words
The multisensor cell assembly of claim 8 wherein there are three ion selective electrodes.
Claim 15
Dependent Claim
126 words
A multisensor cell assembly for determining an anion of interest in a biological sample comprising: an electrically insulative substrate having a surface with a reference electrode and at least one ion selective electrode formed thereon, wherein one ion selective electrode has an anion selective membrane comprising a polymer material, an anion-selective agent, and from about 5% to about 50% by weight fumed silica; and an elastomeric component positioned on the surface of the substrate defining a reference and sensor flow channel, the reference flow channel having means for passing reference liquids over the reference electrode, the sensor flow channel having means for passing sample liquids over each ion selective electrode, the reference and sensor flow channels defining a common outlet for removing liquids from the cell.
Claim 16
Dependent Claim
126 words
A multisensor cell assembly for determining an anion of interest in a biological sample comprising: an electrically insulative substrate having a surface with a reference electrode and at least one ion selective electrode formed thereon, wherein one ion selective electrode has an anion selective membrane comprising a polymer material, an anion-selective agent, and from about 5% to about 50% by weight fumed silica; and an elastomeric component positioned on the surface of the substrate defining a reference and sensor flow channel, the reference flow channel having means for passing reference liquids over the reference electrode, the sensor flow channel having means for passing sample liquids over each ion selective electrode, the reference and sensor flow channels defining a common outlet for removing liquids from the cell.
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