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US5420330A
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Lipo-phosphoramidites
Assignee: Pharmacia PL Biochemicals Inc
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Filing: 1990-09-07
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Granted: 1995-05-30
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Expires: 2010-09-07
Abstract
Abstract Ether variant lipids bound to phosphoramidites are disclosed. These can be used to create oligonucleotides that are linked to stable lipid-like units. For example, dialkyl glycerols are linked to phosphoramidites.
Inventors
- 👤 Charles K. Brush
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 22:43
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/22; C07F9/24; C07F9/2404; C07F9/2408; C07H21/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
85 words
A compound having the following structure: ##STR3## wherein A 1 , A 2 and A 3 are selected from the group consisting of CH 3 and H, and R 1 , R 2 and R 3 are selected from the group consisting of O-alkyl with 16-18 carbons an O-trityl moiety, and O-phosphoramidite; at least one of R 1 , R 2 and R 3 is O-phosphoramidite; and at least one of R 1 , R 2 and R 3 is an O-alkyl with 16-18 carbons.
Claim 2
Dependent Claim
85 words
A compound having the following structure: ##STR3## wherein A 1 , A 2 and A 3 are selected from the group consisting of CH 3 and H, and R 1 , R 2 and R 3 are selected from the group consisting of O-alkyl with 16-18 carbons an O-trityl moiety, and O-phosphoramidite; at least one of R 1 , R 2 and R 3 is O-phosphoramidite; and at least one of R 1 , R 2 and R 3 is an O-alkyl with 16-18 carbons.
Claim 3
Dependent Claim
10 words
The compound of claim 1, wherein R 2 is O-phosphoramidite.
Claim 4
Dependent Claim
17 words
The compound of claim 2, wherein R 1 and R 3 are an O-alkyl with 16-18 carbons.
Claim 5
Dependent Claim
82 words
A compound having the following structure: ##STR4## wherein A 1 , A 2 and A 3 are selected from the group consisting of CH 3 and H, and R 1 , R 2 and R 3 are selected from the group consisting of O-alkyl with 16-18 carbons an O-trityl moiety, and O-phosphoramidite; at least one of R 1 and R 3 is O-phosphoramidite; and at least one of R 1 , R 2 and R 3 is an O-alkyl with 16-18 carbons.
Claim 6
Dependent Claim
82 words
A compound having the following structure: ##STR4## wherein A 1 , A 2 and A 3 are selected from the group consisting of CH 3 and H, and R 1 , R 2 and R 3 are selected from the group consisting of O-alkyl with 16-18 carbons an O-trityl moiety, and O-phosphoramidite; at least one of R 1 and R 3 is O-phosphoramidite; and at least one of R 1 , R 2 and R 3 is an O-alkyl with 16-18 carbons.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-05-29 | 1998-11-28 | 1999-05-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-05-29 | 2002-11-28 | 2003-05-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-05-29 | 2006-11-28 | 2007-05-30 | $7700.00 | Window Closed / Lapsed |