US5401754A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Agent for treating thrombosis and phosphodiesterase inhibitor
Assignee: Otsuka Pharmaceutical Co Ltd
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Filing: 1994-03-11
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Granted: 1995-03-28
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Expires: 2014-03-11
Abstract
Abstract A pharmaceutical preparation comprising at least one compound selected from the group consisting of carbostyril derivatives having the general formula: <IMAGE> wherein R1 is hydrogen or a lower alkyl group optionally having hydroxy group as a substituent; R2 is a phenyl(lower alkyl) group optionally having 1 to 3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the phenyl ring, pyridyl(lower alkyl) group, or a group of the formula -A-NR3R4 (wherein A is a lower alkylene group, R3 and R4 are the same or different and represent a lower alkyl group or phenyl group), and a salt thereof, which is useful as an agent for treating thrombosis, more particularly, as an agent for inhibiting platelet aggregation and as an agent for platelet aggregate dissociation.
Inventors
- 👤 Takafumi Fujioka
- 👤 Shuji Teramoto
- 👤 Michiaki Tominaga
- 👤 Yoichi Yabuuchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:27
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/20; C07D215/22; C07D215/227; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61P; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P25/00; A61P25/18; A61P3/00; A61P3/08; A61P3/10; A61P35/00; A61P43/00; A61P7/00; A61P7/02; A61P9/00; A61P9/10
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
120 words
A method for treating thrombosis comprising administering to a subject an anti-thrombotic effective amount of a carbostyril derivative of the formula: ##STR3## wherein R 1 represents hydrogen or a lower alkyl group optionally having a hydroxy group as a substituent; R 2 represents a phenyl(lower alkyl) group optionally having 1-3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the phenyl ring; a pyridyl(lower alkyl) group; and a group of the formula --A--NR 3 R 4 , wherein A represents a lower alkylene group, and wherein R 3 and R 4 , which are the same or different, represent a lower alkyl group or phenyl group; or a salt of said carbostyril derivative.
Claim 2
Independent Claim
120 words
A method for treating thrombosis comprising administering to a subject an anti-thrombotic effective amount of a carbostyril derivative of the formula: ##STR3## wherein R 1 represents hydrogen or a lower alkyl group optionally having a hydroxy group as a substituent; R 2 represents a phenyl(lower alkyl) group optionally having 1-3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the phenyl ring; a pyridyl(lower alkyl) group; and a group of the formula --A--NR 3 R 4 , wherein A represents a lower alkylene group, and wherein R 3 and R 4 , which are the same or different, represent a lower alkyl group or phenyl group; or a salt of said carbostyril derivative.
Claim 3
Dependent Claim
15 words
The method for treating thrombosis of claim 1, wherein said method involves inhibiting platelet aggregation.
Claim 4
Dependent Claim
14 words
The method for treating thrombosis of claim 1, wherein the carbostyril derivative is 6-[3-(3-methoxybenzyl)amino-2-hydroxypropoxy]carbostyril.
Claim 5
Dependent Claim
13 words
The method for treating thrombosis of claim 1, wherein the carbostyril derivatives 6-[3-(3,4-dimethoxybenzyl)amino-2-hydroxypropoxy]carbostyril.
Claim 6
Dependent Claim
14 words
The method for treating thrombosis of claim 2, wherein the carbostyril derivative is 6-[3-(3-methoxybenzyl)amino-2-hydroxypropoxy]carbostyril.
Claim 7
Dependent Claim
14 words
The method for treating thrombosis of claim 2, wherein the carbostyril derivative is 6-[3-(3,4-dimethoxybenzyl)amino-2-hydroxypropoxy]carbostyril.
Claim 8
Dependent Claim
38 words
The method for treating thrombosis of claim 1, wherein R 2 is a phenyl(lower alkyl) group optionally having 1-3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the phenyl ring.
Claim 9
Dependent Claim
15 words
The method for treating thrombosis of claim 7, wherein said method involved inhibiting platelet aggregation.
Claim 10
Independent Claim
122 words
A method for dissociating platelet aggregation comprising administering to subject a platelet aggregation dissociation effective amount of a .carbostyril derivative of the formula: ##STR4## wherein R 1 represents hydrogen or a lower alkyl group optionally having a hydroxy group as a substituent; R 2 represents a phenyl(lower alkyl) group optionally having 1-3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the phenyl ring; a pyridyl(lower alkyl) group; and a group of the formula --A--NR 3 R 4 , wherein A represents a lower alkylene group; and wherein R 3 and R 4 , which are the same or different, represent a lower alkyl group or phenyl group; or a salt of said carbostyril derivative.
Claim 11
Independent Claim
122 words
A method for dissociating platelet aggregation comprising administering to subject a platelet aggregation dissociation effective amount of a .carbostyril derivative of the formula: ##STR4## wherein R 1 represents hydrogen or a lower alkyl group optionally having a hydroxy group as a substituent; R 2 represents a phenyl(lower alkyl) group optionally having 1-3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the phenyl ring; a pyridyl(lower alkyl) group; and a group of the formula --A--NR 3 R 4 , wherein A represents a lower alkylene group; and wherein R 3 and R 4 , which are the same or different, represent a lower alkyl group or phenyl group; or a salt of said carbostyril derivative.
Claim 12
Dependent Claim
15 words
The method for dissociating platelet aggregation of claim 9, wherein the carbostyril derivative is 6-[3-(3-methoxybenzyl)amino-2-hydroxypropoxy]carbostyril
Claim 13
Dependent Claim
15 words
The method for dissociating platelet aggregation of claim 9, wherein the carbostyril derivative is 6-[3-(3,4-dimethoxybenzyl)amino-2-hydroxypropoxy]carbostyril.
Claim 14
Dependent Claim
39 words
The method for dissociating platelet aggregation of claim 9, wherein R 2 is a phenyl(lower alkyl) group optionally having 1-3 substituents selected from the group consisting of a lower alkoxy group and a halogen atom on the phenyl ring.
Claim 15
Independent Claim
37 words
The method according to any one of claims 1, 2, or 9, wherein the effective amount of the carbostyril derivative is in the range of about 0.1 to 10 mg per kg of body weight per day.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-03-27 | 1998-09-26 | 1999-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-03-27 | 2002-09-26 | 2003-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-03-27 | 2006-09-26 | 2007-03-28 | $7700.00 | Window Closed / Lapsed |