Antihistamine

Abstract

Abstract PURPOSE: An antihistamine comprising a carbostyril derivative or its acid addition salt, a novel compound, as an active ingredient. CONSTITUTION: An antihistamine comprising a compound shwon by the formula (R 1 is H, lower alkyl, etc.; R 2 is phenyl, phenylalkyl, etc.; R 3 is H, lower alkyl, etc; carbon-carbon bond between 3W4 positions of carbostyril skeleton is single or double bond) or its acid addition salt, a novel compound, as an active ingredient. A well-known compound shown by the formula I has β-adrenergic neuronal blocking action and is known as a remedy for arrhythmia and angina heterochronicus. The novel compound shown by the formula prevents the linking between a free activated histamine and a histamine acceptor and exhibits an antihistamine action. A dose of 40μgW2mg/kg/day is applied to patients of various kinds of allergies, e.g., hay fever, pollinosis, etc. COPYRIGHT: (C)1981,JPO&Japio

Inventors

• 👤 Kazuhisa Sakano
• 👤 Takafumi Fujioka
• 👤 Yasuo Oshiro
• 👤 Kazuyuki Nakagawa

Bibliographic Details