US5395366A — Sampling capsule and process

Claim 1

Independent Claim 87 words

An ingestible capsule for removal of a fluid sample from the alimentary canal of an animal comprising, an electric power source; a radio signal transmitting means in enabling circuitry with said power source, said transmitting means being suitable for transmitting a radio signal the location from which the transmission emanates being trackable through animal tissue; a fluid sample storage compartment; means for obtaining a fluid sample from said alimentary canal; all encased in an essentially non-digestible outer shell that is configured to pass through said alimentary canal.

Claim 2

Dependent Claim 87 words

An ingestible capsule for removal of a fluid sample from the alimentary canal of an animal comprising, an electric power source; a radio signal transmitting means in enabling circuitry with said power source, said transmitting means being suitable for transmitting a radio signal the location from which the transmission emanates being trackable through animal tissue; a fluid sample storage compartment; means for obtaining a fluid sample from said alimentary canal; all encased in an essentially non-digestible outer shell that is configured to pass through said alimentary canal.

Claim 3

Dependent Claim 19 words

The capsule of claim 1 wherein said means for obtaining said fluid sample is actuatable remote from said capsule.

Claim 4

Dependent Claim 13 words

The capsule of claim 1 wherein said electric power source comprises a battery.

Claim 5

Dependent Claim 28 words

The capsule of claim 1 wherein said transmitting means emits a radio signal, detectable exterior of said outer shell of said capsule when enabled by said power source.

Claim 6

Dependent Claim 29 words

The capsule of claim 2 wherein said means for obtaining said fluid sample is actuatable by radio signal transmitted from a site exterior of the body of said animal.

Claim 7

Dependent Claim 12 words

The capsule of claim 1 wherein said enabling circuitry comprises switching means.

Claim 8

Dependent Claim 25 words

The capsule of claim 1 comprising a passageway for the flow of fluid from the exterior of said capsule to the interior of said capsule.

Claim 9

Dependent Claim 17 words

The capsule of claim 7 comprising means arranged to resist the flow of fluid through said passageway.

Claim 10

Dependent Claim 21 words

The capsule of claim 8 wherein said means arranged to resist the flow of fluid comprises a one way flap means.

Claim 11

Dependent Claim 34 words

The capsule of claim 7 wherein said passageway comprises a closable opening through said outer shell to a storage compartment within said capsule, said closable opening comprising a spring assisted one way valve means.

Claim 12

Dependent Claim 25 words

The capsule of claim 1 wherein said means for obtaining a fluid sample comprises activating means arranged to initiate sampling activity of a sampling means.

Claim 13

Dependent Claim 27 words

The capsule of claim 11 wherein said activating means comprises means for receiving a radio signal transmitted from a site exterior of the body of said animal.

Claim 14

Dependent Claim 23 words

The capsule of claim 11 wherein said activating means comprises an initiator coil that is characterized by a detectable resonate frequency when activated.

Claim 15

Dependent Claim 34 words

The capsule of claim 12 comprising means for enabling the flow of electricity from said power source to said sampling means in response to receiving said radio signal from a site exterior said body.

Claim 16

Dependent Claim 32 words

The capsule of claim 14 wherein said sampling means comprises a filament, which is arranged to heat a thermal sensitive adhesive when the flow of electricity from said power source is enabled.

Claim 17

Dependent Claim 30 words

The capsule of claim 15 wherein said thermal sensitive adhesive is comprised in an arrangement which restrains a spring, and heating of said adhesive by said filament releases said restraint.

Claim 18

Dependent Claim 79 words

The capsule of claim 16 wherein said sampling means comprises a piston which is arranged in said sample storage compartment, release of said spring urges said piston from a first position in said compartment to a second position, and the movement of said piston creates a partial vacuum in a portion of said storage compartment which influences the flow of a fluid from said alimentary canal through a passageway in said capsule to said portion of said storage compartment.

Claim 19

Dependent Claim 22 words

The capsule of claim 17 wherein said filament breaks through movement of said piston and the flow of electricity therethrough is disconnected.

Claim 20

Dependent Claim 17 words

The capsule of claim 18 wherein breaking said filament changes the resonate frequency of said initiator coil.

Claim 21

Dependent Claim 41 words

The capsule of claim 1 wherein said sampling means comprises a movable piston adapted to influence the flow of a fluid from the alimentary canal into said capsule, through movement of said piston from a first position to a second position.

Claim 22

Dependent Claim 20 words

The capsule of claim 20 wherein said movement of said piston creates a pressure in a portion of said capsule.

Claim 23

Dependent Claim 17 words

The capsule of claim 21 comprising means for relieving said pressure in said portion of said capsule.

Claim 24

Dependent Claim 46 words

The capsule of claim 22 wherein said means for relieving said pressure comprises a pressure induced opening to the exterior of said capsule through which air can flow, and movement of the piston to a said second position restrains said flow of air through said opening.

Claim 25

Dependent Claim 19 words

The capsule of claim 23 wherein said piston comprises means for restraining the flow of fluid through said opening.

Claim 26

Dependent Claim 42 words

The capsule of claim 20 wherein said piston is arranged in said sample storage compartment and movement of said piston from said first position to a second position influences the flow of a fluid from the alimentary canal into said storage compartment.

Claim 27

Dependent Claim 49 words

The capsule of claim 25 wherein said movement of said piston creates a partial vacuum in a portion of said storage compartment which influences the flow of a fluid from said alimentary canal through a passageway from the exterior of said capsule into said portion of said storage compartment.

Claim 28

Dependent Claim 12 words

The capsule of claim 1 wherein said outer shell comprises a polycarbonate.

Claim 29

Dependent Claim 66 words

An ingestible capsule for removal of a fluid sample from the alimentary canal of an animal comprising, a non-digestible outer shell; an electric power source; a radio signal transmitting means; and a fluid sample storage compartment comprising a piston means arranged for withdrawing a fluid sample from said alimentary canal in response to a signal from a signal means remote from the body of said animal.

Claim 30

Dependent Claim 66 words

An ingestible capsule for removal of a fluid sample from the alimentary canal of an animal comprising, a non-digestible outer shell; an electric power source; a radio signal transmitting means; and a fluid sample storage compartment comprising a piston means arranged for withdrawing a fluid sample from said alimentary canal in response to a signal from a signal means remote from the body of said animal.

Claim 31

Dependent Claim 55 words

An ingestible capsule for sampling a fluid from the alimentary canal of an animal comprising, a non-digestible outer shell; an electric power source; a first radio signal transmitting means; a fluid sample storage compartment; means for receiving a second radio signal; and, a fluid sampling means responsive to the receipt of said second radio signal.

Claim 32

Dependent Claim 55 words

An ingestible capsule for sampling a fluid from the alimentary canal of an animal comprising, a non-digestible outer shell; an electric power source; a first radio signal transmitting means; a fluid sample storage compartment; means for receiving a second radio signal; and, a fluid sampling means responsive to the receipt of said second radio signal.

Claim 33

Dependent Claim 20 words

The capsule of claim 29 wherein said fluid sampling means withdraws fluid from said alimentary canal through differential pressure means.

Claim 34

Dependent Claim 14 words

The capsule of claim 29 comprising a fluid sample taken from said alimentary canal.

Claim 35

Dependent Claim 116 words

A process for the gathering of a fluid sample from a selected site in the alimentary canal of an animal comprising, providing an ingestible capsule containing a signal transmitting means and a remote actuatable fluid sampling means; ingesting said capsule into the alimentary canal; transmitting a signal, trackable through animal tissue, from said transmitting means contained in said capsule, said signal being suitable for determining location of said capsule; receiving said transmitted signal exterior of the body of said animal; comparing said signal to a pre-established model; transmitting an actuating signal to said remote actuatable fluid sampling means contained in said capsule; and gathering a fluid sample in said capsule in response to said actuating signal.

Claim 36

Dependent Claim 116 words

A process for the gathering of a fluid sample from a selected site in the alimentary canal of an animal comprising, providing an ingestible capsule containing a signal transmitting means and a remote actuatable fluid sampling means; ingesting said capsule into the alimentary canal; transmitting a signal, trackable through animal tissue, from said transmitting means contained in said capsule, said signal being suitable for determining location of said capsule; receiving said transmitted signal exterior of the body of said animal; comparing said signal to a pre-established model; transmitting an actuating signal to said remote actuatable fluid sampling means contained in said capsule; and gathering a fluid sample in said capsule in response to said actuating signal.

Claim 37

Dependent Claim 12 words

The process of claim 32 wherein said signal is a radio signal.

Claim 38

Dependent Claim 24 words

The process of claim 33 wherein said radio signal, transmitted from said transmitting means in said capsule, is converted to an intermediate frequency signal.

Claim 39

Dependent Claim 17 words

The process of claim 34 wherein an intermediate frequency signal is quantified as a DC voltage signal.

Claim 40

Dependent Claim 19 words

The process of claim 35 wherein a quantified DC voltage signal is digitized to provide input to a computer.

Claim 41

Dependent Claim 35 words

The process of claim 32 wherein a radio signal is transmitted from said transmitting means in said capsule and is received at multiple receiving antennae arranged about the exterior of the body of said animal.

Claim 42

Dependent Claim 28 words

The process of claim 37 wherein the output of said multiple receiving antennae is directed to time multiplexing means and said output is converted to time multiplexed output.

Claim 43

Dependent Claim 36 words

The process of claim 38 wherein a time multiplexed output of the multiple receiving antennae is converted to an intermediate frequency signal, quantified as a DC voltage signal and digitized to provide input to a computer.

Claim 44

Dependent Claim 24 words

The process of claim 32 where digitized information from said transmitted signal is compared to digitized information from said pre-established model in a computer.

Claim 45

Dependent Claim 27 words

The process of claim 32 wherein said pre-established model comprises historic data obtained from the previous passage of a radio signal transmitting capsule through said alimentary canal.

Claim 46

Dependent Claim 39 words

The process of claim 32 wherein said pre-established model comprises digitized information having parameters comprising one of a rate of progress of said capsule through said canal, length of time of said capsule in said canal or normalized model.

Claim 47

Dependent Claim 33 words

The process of claim 32 wherein sampling of said fluid initiates a sampling indicator signal, by sampling indicator means comprised in said capsule, which is detectable exterior of the body of said animal.

Claim 48

Dependent Claim 22 words

The process of claim 32 wherein said transmitted signal is received exterior of the animal body, digitized and provided to a computer.

Claim 49

Dependent Claim 25 words

The process of claim 44 wherein said pre-established model comprises digitized historic data obtained from the previous passage of a capsule through said alimentary canal.

Claim 50

Dependent Claim 34 words

The process of claim 44 wherein said pre-established model comprises one of a rate of progress of said capsule through said canal, length of time of said capsule in said canal or normalized model.

Claim 51

Dependent Claim 18 words

The process of claim 44 wherein said computer is programmed to scan and compute variations from pre-programmed factors.

Claim 52

Dependent Claim 14 words

The process of claim 44 wherein transmission of said activating signal is operator controlled.

Claim 53

Dependent Claim 23 words

The process of claim 44 wherein said computer is programmed to initiate an actuating signal to the fluid sampling means of the capsule.

Claim 54

Dependent Claim 33 words

The process of claim 49 wherein sampling of said fluid initiates a sampling indicator signal, by sampling indicator means comprised in said capsule, which is detectable exterior of the body of said animal.

Claim 55

Dependent Claim 36 words

The process of claim 50 wherein said computer is programmed to re-initiate an activating signal when a sampling indicator signal is not received from said capsule after an actuating signal has been initiated by said computer.

Claim 56

Dependent Claim 17 words

The process of claim 32 comprising two or more capsules in the alimentary canal transmitting differential signals.

Claim 57

Dependent Claim 54 words

The process of claim 32 wherein a first ingestible capsule, containing a signal transmitting means, is ingested into said alimentary canal; a signal transmitted from said first capsule is received exterior of said body and digitized in a computer; and digitized data from said signal transmitted from said first capsule comprises said pre-established model.

Claim 58

Dependent Claim 95 words

A process for the collection of data for the sampling of a fluid at a selected site in the alimentary canal of an animal comprising, providing an ingestible capsule containing a radio signal transmitting means suitable for determining location of said capsule; ingesting said capsule into the alimentary canal; transmitting a radio signal from said transmitting means; receiving said transmitted signal exterior of the body of said animal at multiple receiving antennae arranged about said canal; digitizing said signal received by said multiple receiving antennae; storing said digitized signal in computer recoverable, time sequence memory.

Claim 59

Dependent Claim 95 words

A process for the collection of data for the sampling of a fluid at a selected site in the alimentary canal of an animal comprising, providing an ingestible capsule containing a radio signal transmitting means suitable for determining location of said capsule; ingesting said capsule into the alimentary canal; transmitting a radio signal from said transmitting means; receiving said transmitted signal exterior of the body of said animal at multiple receiving antennae arranged about said canal; digitizing said signal received by said multiple receiving antennae; storing said digitized signal in computer recoverable, time sequence memory.

Claim 60

Dependent Claim 29 words

The process of claim 54 wherein said stored digitized signal is compared to digitized data derived from transmitted signals from the passage of another capsule through said alimentary canal.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1998-03-06	1998-09-05	1999-03-07	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2002-03-06	2002-09-05	2003-03-07	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2006-03-06	2006-09-05	2007-03-07	$7700.00	Window Closed / Lapsed

Sampling capsule and process

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