US5387236A
Expired / Lapsed
US
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Vascular prosthesis, manufacturing method of the same, and substrate for vascular prosthesis
Assignee: Koken Co Ltd
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Filing: 1992-12-10
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Granted: 1995-02-07
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Expires: 2012-12-10
Abstract
Abstract The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate; a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a substrate suitable for manufacturing a vascular prosthesis having a porous membrane having pores capable of trapping tissue fragments, or a laminate structure with such a membrane and another porous membrane having pores not large enough to pass the cells or tissue fragments.
Inventors
- 👤 Yasuhara Noishiki
- 👤 Teruo Miyata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 03:40
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/062; Y; Y10; Y10S; Y10S623/00; Y10S623/901; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
118 words
The process for manufacturing a laminated vascular prosthesis substrate comprising the steps of: providing a laminated vascular prothesis having a lower porosity layer impermeable to passage of one of biological tissues fragments, vascular cells and combinations thereof and a higher porosity layer permeable to passage of the one of biological tissues, fragments, vascular cells and combinations thereof, providing a pressure differential between an inside and an outside of the laminated vascular prosthesis; and introducing a dispersed solution of the one of biological tissue fragments, vascular cells and combinations thereof to a higher pressure side of the substrate and depositing and capturing the one of tissue fragments, vascular cells and combinations thereof between the lower and higher porosity layers.
Claim 2
Dependent Claim
118 words
The process for manufacturing a laminated vascular prosthesis substrate comprising the steps of: providing a laminated vascular prothesis having a lower porosity layer impermeable to passage of one of biological tissues fragments, vascular cells and combinations thereof and a higher porosity layer permeable to passage of the one of biological tissues, fragments, vascular cells and combinations thereof, providing a pressure differential between an inside and an outside of the laminated vascular prosthesis; and introducing a dispersed solution of the one of biological tissue fragments, vascular cells and combinations thereof to a higher pressure side of the substrate and depositing and capturing the one of tissue fragments, vascular cells and combinations thereof between the lower and higher porosity layers.
Claim 3
Dependent Claim
72 words
The process of claim 1, wherein the laminated vascular prosthesis is provided by coating a surface of a porous substrate with a layer of a biologically acceptable material having pores impermeable to passage of the one of biological tissue fragments, vascular cells and combinations thereof, and after introducing said dispersed solution the one of biological tissue fragments, vascular cells and combinations thereof are captured between the porous substrate and the coated layer.
Claim 4
Dependent Claim
26 words
The process of claim 2, wherein the layer of biologically acceptable material is insolubilized collagen and is placed on an inner surface of the porous substrate.
Claim 5
Dependent Claim
147 words
The process for manufacturing a laminated vascular, prosthesis comprising the steps of: providing a laminated vascular prosthesis substrate having a lower porosity layer impermeable to passage of one of biological tissues fragments, vascular cells and combinations thereof and a higher porosity layer permeable to passage of the one of biological tissues, fragments, vascular cells and combinations thereof, providing a pressure differential between an inside and an outside of the laminated vascular prosthesis; and introducing a dispersed solution of the one of biological tissue fragments, vascular cells and combinations thereof to a higher pressure side of the substrate and depositing and capturing the one of tissue fragments, vascular cells and combinations thereof between the lower and higher porosity layers, wherein the biological tissue fragments comprise vascular tissues, connective tissues, fat tissues and muscular tissues, and the vascular cells comprise vascular endothelial cells, smooth muscle cells and fibroblast cells.
Claim 6
Dependent Claim
147 words
The process for manufacturing a laminated vascular, prosthesis comprising the steps of: providing a laminated vascular prosthesis substrate having a lower porosity layer impermeable to passage of one of biological tissues fragments, vascular cells and combinations thereof and a higher porosity layer permeable to passage of the one of biological tissues, fragments, vascular cells and combinations thereof, providing a pressure differential between an inside and an outside of the laminated vascular prosthesis; and introducing a dispersed solution of the one of biological tissue fragments, vascular cells and combinations thereof to a higher pressure side of the substrate and depositing and capturing the one of tissue fragments, vascular cells and combinations thereof between the lower and higher porosity layers, wherein the biological tissue fragments comprise vascular tissues, connective tissues, fat tissues and muscular tissues, and the vascular cells comprise vascular endothelial cells, smooth muscle cells and fibroblast cells.
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