US5366903A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of photometric in vitro determination of the content of an analyte in a sample of whole blood
Assignee: Radiometer AS
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Filing: 1994-02-22
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Granted: 1994-11-22
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Expires: 2014-02-22
Abstract
Abstract A sampling device for photometric determination of the content of an analyte in a sample of whole blood has at least one measuring chamber having two wall parts, at least one wall part being locally transparent, at least one wall part being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber. The measuring chamber also contains a transparent body having a radiation transmission characteristic dependent upon the concentration of a predetermined analyte in the whole blood sample. The sample device is employed in an analyzer for photometric determination of the content of an analyte in a sample of whole blood and in a method of photometric in vitro determination of the content of an analyte in a sample of whole blood. In the method, a sample of whole blood is transferred directly from an in vivo locality to the sampling device, the measuring chamber therein is deformed in a controlled manner to substantially drain the whole blood from the measuring chamber, radiation is transmitted through the substantially drained measuring chamber, detected, and the analyte content determined.
Inventors
- 👤 Finn C. Lundsgaard
- 👤 Niels-Henrik Jensen
- 👤 Willy Andersen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 19:09
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/01; G01N21/03; G01N21/17; G01N21/25; G01N21/251; G01N21/255; G01N21/27; G01N21/274; G01N21/276; G01N21/62; G01N21/63; G01N21/64; G01N21/6408; G01N21/6428; G01N21/75; G01N21/77; G01N21/78; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4925; G01N33/497; G01N2021/0346; G01N2021/036; G01N2021/0364; G01N21/31; G01N21/314; G01N2021/3148; G01N2021/3166; G01N2021/6417; G01N2021/6432; G01N2021/6439; G01N2021/7769; G01N2021/7786; G01N21/84; G01N2021/8405; G01N35/00; G01N2035/00178; G01N2035/00306; G01N2035/00316; G01N35/10; G01N2035/1027; G01N2035/1048; G01N2035/1062; G01N21/05; G01N21/80; G01N2201/00; G01N2201/04; G01N2201/0407; G01N2201/0476; G01N2201/06; G01N2201/061; G01N2201/06166; G01N2201/0618; G01N2201/12; G01N2201/128; G01N2201/1288
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
174 words
A sampling device for photometric determination of the content of an analyte in a sample of whole blood, comprising: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the radiation modification after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed.
Claim 2
Dependent Claim
174 words
A sampling device for photometric determination of the content of an analyte in a sample of whole blood, comprising: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the radiation modification after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed.
Claim 3
Dependent Claim
299 words
An analyzer for photometric determination of the content of an analyte in a sample of whole blood comprising: a) a radiation source; b) means for detecting radiation transmitted from the radiation source; c) a sampling device comprising: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the radiation modification after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed; d) a sampling device station containing the sampling device; and e) means for deforming the wall parts of the at least one measuring chamber in the sampling device in a controlled manner to reduce the volume of the at least one measuring chamber such that the sample of whole blood is substantially drained from the at least one measuring chamber, wherein the sampling device station of step (d) is arranged relative to the radiation source and the radiation detection means so that the radiation transmitted from the radiation source will pass through the at least one volume-reduced measuring chamber to the radiation detection means.
Claim 4
Dependent Claim
299 words
An analyzer for photometric determination of the content of an analyte in a sample of whole blood comprising: a) a radiation source; b) means for detecting radiation transmitted from the radiation source; c) a sampling device comprising: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the radiation modification after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed; d) a sampling device station containing the sampling device; and e) means for deforming the wall parts of the at least one measuring chamber in the sampling device in a controlled manner to reduce the volume of the at least one measuring chamber such that the sample of whole blood is substantially drained from the at least one measuring chamber, wherein the sampling device station of step (d) is arranged relative to the radiation source and the radiation detection means so that the radiation transmitted from the radiation source will pass through the at least one volume-reduced measuring chamber to the radiation detection means.
Claim 5
Independent Claim
336 words
A method of photometric determination of the content of an analyte in a sample of whole blood, comprising the steps of: a) transferring a sample of whole blood directly from an in vivo locality to a sampling device, wherein the sampling device comprises: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the radiation modification after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed; b) placing the sampling device in a sampling device station wherein the sampling device station is arranged relative to an optical system comprising a radiation source and a means for detecting radiation, such that the sampling device is located between the radiation source and the radiation detection means; c) deforming the at least one measuring chamber of the sampling device in a controlled manner to reduce the volume of the at least one measuring chamber, thereby substantially draining the sample of whole blood from the measuring chamber; d) transmitting radiation from the radiation source through the deformed, substantially drained at least one measuring chamber to the radiation detector; e) detecting the radiation transmitted in step d); and f) determining the analyte content of the sample of whole blood from the radiation detected in step e).
Claim 6
Independent Claim
336 words
A method of photometric determination of the content of an analyte in a sample of whole blood, comprising the steps of: a) transferring a sample of whole blood directly from an in vivo locality to a sampling device, wherein the sampling device comprises: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the radiation modification after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed; b) placing the sampling device in a sampling device station wherein the sampling device station is arranged relative to an optical system comprising a radiation source and a means for detecting radiation, such that the sampling device is located between the radiation source and the radiation detection means; c) deforming the at least one measuring chamber of the sampling device in a controlled manner to reduce the volume of the at least one measuring chamber, thereby substantially draining the sample of whole blood from the measuring chamber; d) transmitting radiation from the radiation source through the deformed, substantially drained at least one measuring chamber to the radiation detector; e) detecting the radiation transmitted in step d); and f) determining the analyte content of the sample of whole blood from the radiation detected in step e).
Claim 7
Dependent Claim
164 words
A measuring chamber for photometric determination of the content of an analyte in a sample of whole blood, comprising: two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber for photometric analysis, the measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the radiation modification after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed.
Claim 8
Dependent Claim
164 words
A measuring chamber for photometric determination of the content of an analyte in a sample of whole blood, comprising: two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber for photometric analysis, the measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the radiation modification after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed.
Claim 9
Dependent Claim
285 words
An analyzer for photometric determination of the content of an analyte in a sample of whole blood, comprising: a) a radiation source; b) means for detecting radiation transmitted from the radiation source; c) at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the two wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the radiation modification after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed, wherein the at least one measuring chamber is arranged relative to the radiation source and the radiation detection means so that the radiation transmitted from the radiation source will pass through the at least one measuring chamber to the radiation detection means; and d) means for deforming at least one of the wall parts of the at least one measuring chamber in a controlled manner to reduce the volume of the at least one measuring chamber such that the sample of whole blood is substantially drained from the at least one measuring chamber.
Claim 10
Dependent Claim
285 words
An analyzer for photometric determination of the content of an analyte in a sample of whole blood, comprising: a) a radiation source; b) means for detecting radiation transmitted from the radiation source; c) at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the two wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the radiation modification after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed, wherein the at least one measuring chamber is arranged relative to the radiation source and the radiation detection means so that the radiation transmitted from the radiation source will pass through the at least one measuring chamber to the radiation detection means; and d) means for deforming at least one of the wall parts of the at least one measuring chamber in a controlled manner to reduce the volume of the at least one measuring chamber such that the sample of whole blood is substantially drained from the at least one measuring chamber.
Claim 11
Independent Claim
290 words
A method of photometric in vitro determination of the content of an analyte in a sample of whole blood, comprising the steps of: a) transferring a sample of whole blood to a measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber for photometric analysis, the measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the detectable radiation modification after displacement of the whole blood sample from the measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed, the measuring chamber being arranged relative to an optical system comprised of a radiation source and a means for detecting radiation such that the measuring chamber is located between the radiation source and the radiation detection means; b) deforming the measuring chamber in a controlled manner to reduce the volume of the measuring chamber thereby substantially draining the sample of whole blood from the measuring chamber; c) transmitting radiation from the radiation source through the deformed, substantially drained measuring chamber to the radiation detector; d) detecting the radiation transmitted in step c); and e) determining the analyte content of the sample of whole blood from the radiation detected in step d).
Claim 12
Independent Claim
290 words
A method of photometric in vitro determination of the content of an analyte in a sample of whole blood, comprising the steps of: a) transferring a sample of whole blood to a measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber for photometric analysis, the measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body a detectable radiation modification is caused in the transparent body which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the detectable radiation modification after displacement of the whole blood sample from the measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed, the measuring chamber being arranged relative to an optical system comprised of a radiation source and a means for detecting radiation such that the measuring chamber is located between the radiation source and the radiation detection means; b) deforming the measuring chamber in a controlled manner to reduce the volume of the measuring chamber thereby substantially draining the sample of whole blood from the measuring chamber; c) transmitting radiation from the radiation source through the deformed, substantially drained measuring chamber to the radiation detector; d) detecting the radiation transmitted in step c); and e) determining the analyte content of the sample of whole blood from the radiation detected in step d).
Claim 13
Dependent Claim
179 words
A sampling device for photometric determination of the content of an analyte in a sample of whole blood, comprising: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed.
Claim 14
Dependent Claim
179 words
A sampling device for photometric determination of the content of an analyte in a sample of whole blood, comprising: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed.
Claim 15
Dependent Claim
304 words
An analyzer for photometric determination of the content of an analyte in a sample of whole blood comprising: a) a radiation source; b) means for detecting radiation transmitted from the radiation source; c) a sampling device comprising: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed; d) a sampling device station containing the sampling device; and e) means for deforming the wall parts of the at least one measuring chamber in the sampling device in a controlled manner to reduce the volume of the at least one measuring chamber such that the sample of whole blood is substantially drained from the at least one measuring chamber, wherein the sampling device station of step (d) is arranged relative to the radiation source and the radiation detection means so that the radiation transmitted from the radiation source will pass through the at least one volume-reduced measuring chamber to the radiation detection means.
Claim 16
Dependent Claim
304 words
An analyzer for photometric determination of the content of an analyte in a sample of whole blood comprising: a) a radiation source; b) means for detecting radiation transmitted from the radiation source; c) a sampling device comprising: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed; d) a sampling device station containing the sampling device; and e) means for deforming the wall parts of the at least one measuring chamber in the sampling device in a controlled manner to reduce the volume of the at least one measuring chamber such that the sample of whole blood is substantially drained from the at least one measuring chamber, wherein the sampling device station of step (d) is arranged relative to the radiation source and the radiation detection means so that the radiation transmitted from the radiation source will pass through the at least one volume-reduced measuring chamber to the radiation detection means.
Claim 17
Independent Claim
341 words
A method of photometric determination of the content of an analyte in a sample of whole blood, comprising the steps of: a) transferring a sample of whole blood directly from an in vivo locality to a sampling device, wherein the sampling device comprises: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed; b) placing the sampling device in a sampling device station wherein the sampling device station is arranged relative to an optical system comprising a radiation source and a means for detecting radiation, such that the sampling device is located between the radiation source and the radiation detection means; c) deforming the at least one measuring chamber of the sampling device in a controlled manner to reduce the volume of the at least one measuring chamber, thereby substantially draining the sample of whole blood from the measuring chamber; d) transmitting radiation from the radiation source through the deformed, substantially drained at least one measuring chamber to the radiation detector; e) detecting the radiation transmitted in step d); and f) determining the analyte content of the sample of whole blood from the radiation detected in step e).
Claim 18
Independent Claim
341 words
A method of photometric determination of the content of an analyte in a sample of whole blood, comprising the steps of: a) transferring a sample of whole blood directly from an in vivo locality to a sampling device, wherein the sampling device comprises: at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed; b) placing the sampling device in a sampling device station wherein the sampling device station is arranged relative to an optical system comprising a radiation source and a means for detecting radiation, such that the sampling device is located between the radiation source and the radiation detection means; c) deforming the at least one measuring chamber of the sampling device in a controlled manner to reduce the volume of the at least one measuring chamber, thereby substantially draining the sample of whole blood from the measuring chamber; d) transmitting radiation from the radiation source through the deformed, substantially drained at least one measuring chamber to the radiation detector; e) detecting the radiation transmitted in step d); and f) determining the analyte content of the sample of whole blood from the radiation detected in step e).
Claim 19
Dependent Claim
169 words
A measuring chamber for photometric determination of the content of an analyte in a sample of whole blood, comprising: two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber for photometric analysis, the measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed.
Claim 20
Dependent Claim
169 words
A measuring chamber for photometric determination of the content of an analyte in a sample of whole blood, comprising: two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber for photometric analysis, the measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed.
Claim 21
Dependent Claim
290 words
An analyzer for photometric determination of the content of an analyte in a sample of whole blood, comprising: a) a radiation source; b) means for detecting radiation transmitted from the radiation source; c) at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the two wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed, wherein the at least one measuring chamber is arranged relative to the radiation source and the radiation detection means so that the radiation transmitted from the radiation source will pass through the at least one measuring chamber to the radiation detection means; and d) means for deforming at least one of the wall parts of the at least one measuring chamber in a controlled manner to reduce the volume of the at least one measuring chamber such that the sample of whole blood is substantially drained from the at least one measuring chamber.
Claim 22
Dependent Claim
290 words
An analyzer for photometric determination of the content of an analyte in a sample of whole blood, comprising: a) a radiation source; b) means for detecting radiation transmitted from the radiation source; c) at least one measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the two wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the at least one measuring chamber for photometric analysis, the at least one measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the at least one measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed, wherein the at least one measuring chamber is arranged relative to the radiation source and the radiation detection means so that the radiation transmitted from the radiation source will pass through the at least one measuring chamber to the radiation detection means; and d) means for deforming at least one of the wall parts of the at least one measuring chamber in a controlled manner to reduce the volume of the at least one measuring chamber such that the sample of whole blood is substantially drained from the at least one measuring chamber.
Claim 23
Independent Claim
294 words
A method of photometric in vitro determination of the content of an analyte in a sample of whole blood, comprising the steps of: a) transferring a sample of whole blood to a measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber for photometric analysis, the measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed, the measuring chamber being arranged relative to an optical system comprised of a radiation source and a means for detecting radiation such that the measuring chamber is located between the radiation source and the radiation detection means; b) deforming the measuring chamber in a controlled manner to reduce the volume of the measuring chamber thereby substantially draining the sample of whole blood from the measuring chamber; c) transmitting radiation from the radiation source through the deformed, substantially drained measuring chamber to the radiation detector; d) detecting the radiation transmitted in step c); and e) determining the analyte content of the sample of whole blood from the radiation detected in step d).
Claim 24
Independent Claim
294 words
A method of photometric in vitro determination of the content of an analyte in a sample of whole blood, comprising the steps of: a) transferring a sample of whole blood to a measuring chamber which has two wall parts located opposite one another, at least one of the wall parts being locally transparent, at least one of the wall parts being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber for photometric analysis, the measuring chamber further including a transparent body disposed between the wall parts, the transparent body being capable of selectively absorbing the analyte or reacting with the analyte such that upon contact of the analyte with the transparent body, a detectable change in a radiation transmission characteristic of the transparent body occurs which is dependent upon the concentration of the analyte in the whole blood sample, wherein the transparent body maintains the changed radiation transmission characteristic after displacement of the whole blood sample from the measuring chamber so that photometric analysis of the analyte in the absence of the whole blood sample can be performed, the measuring chamber being arranged relative to an optical system comprised of a radiation source and a means for detecting radiation such that the measuring chamber is located between the radiation source and the radiation detection means; b) deforming the measuring chamber in a controlled manner to reduce the volume of the measuring chamber thereby substantially draining the sample of whole blood from the measuring chamber; c) transmitting radiation from the radiation source through the deformed, substantially drained measuring chamber to the radiation detector; d) detecting the radiation transmitted in step c); and e) determining the analyte content of the sample of whole blood from the radiation detected in step d).
References Cited (Backward Citations)
US3926521A
Cited
US4339317A
Cited
US4420254A
Cited
US4426451A
Cited
US4444498A
Cited
US4447150A
Cited
US4454229A
Cited
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-11-21 | 1998-05-23 | 1998-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-11-21 | 2002-05-23 | 2002-11-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-11-21 | 2006-05-23 | 2006-11-22 | $7700.00 | Window Closed / Lapsed |