US5127077A
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US
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Fiber-optic physiological probes
Assignee: Hospira Inc
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Filing: 1990-12-18
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Granted: 1992-06-30
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Expires: 2010-12-18
Abstract
Abstract Fiber optic sensors suitable for monitoring physiological analyte concentrations are described. The sensors include analyte permeable matrices disposed in a light path defined by the axial core at one end of an optical fiber segment. The matrix contains an indicator molecule covalently linked to a polymer or admixed with the polymer. The indicator molecule may be an absorptive molecule or a luminescent molecule. pH, PCO 2 , and PO 2 sensors are described and may be disposed together in substantially coterminal arrangement to make a multivariable probe.
Inventors
- 👤 Lokanathan M. Iyer
- 👤 Jeffrey B. Yim
- 👤 Kenneth S. Lyon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 05:27
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14539; A61B5/1455; A61B5/1459; G; G01; G01N; G01N21/00; G01N21/62; G01N21/63; G01N21/64; G01N21/6428; G01N21/01; G01N21/03; G01N2021/0385; G01N2021/6434; G01N21/75; G01N21/77; G01N21/7703; G01N2021/7706; G01N2021/772; G01N21/78; G01N21/783; G01N21/80; G01N21/84; G01N21/85; G01N21/8507
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
66 words
A fiber optic sensor suitable for monitoring physiological analyte concentration, comprising a preformed film of an analyte permeable matrix disposed in a light path defined by an axial core at one end of an optical fiber segment, the analyte permeable matrix comprising an indicator molecule covalently linked to or admixed with a polymer, the indicator molecule capable of responding to the analyte in an optically-detectable manner.
Claim 2
Dependent Claim
66 words
A fiber optic sensor suitable for monitoring physiological analyte concentration, comprising a preformed film of an analyte permeable matrix disposed in a light path defined by an axial core at one end of an optical fiber segment, the analyte permeable matrix comprising an indicator molecule covalently linked to or admixed with a polymer, the indicator molecule capable of responding to the analyte in an optically-detectable manner.
Claim 3
Dependent Claim
30 words
The fiber-optic sensor of claim 1, wherein the polymer is selected from the group consisting of methyl methacrylate/methacrylamidopropyl trimethylammonium chloride, N-vinylpyrrolidone/p-aminostyrene, methyl methacrylate/hydroxymethyl methacrylate, methyl methacrylate/N-vinylpyrrolidone, and methyl methacrylate/acrylic acid.
Claim 4
Dependent Claim
16 words
The fiber-optic sensor of claim 1, wherein the pre-formed film is supported on a reflective film.
Claim 5
Dependent Claim
14 words
The fiber-optic sensor of claim 3, wherein the preformed film is a preformed pellet.
Claim 6
Dependent Claim
22 words
The fiber-optic sensor of claim 2, wherein the polymers formulated in the range are from about 60:40 to about 80:20 weight/weight percent.
Claim 7
Dependent Claim
22 words
The fiber-optic sensor of claim 1, wherein the polymer comprises approximately 94:6 mole/mole percent of either methyl methacrylate/methylacrylamidopropyltrimethylammonium chloride or N-vinylpyrrolidone/p-aminostyrene copolymer.
Claim 8
Dependent Claim
19 words
The fiber-optic sensor of claim 1, wherein the indicator molecule is covalently linked to the polymer through an aminoarylalkylamine.
Claim 9
Dependent Claim
19 words
The fiber-optic sensor of claim 7, wherein the aminoarylalkylamine is selected from the group consisting of 4-(aminophenyl)-ethylamine and 4-(aminophenyl)-propylamine.
Claim 10
Dependent Claim
14 words
The fiber-optic sensor of claim 1, wherein the indicator molecule is an absorptive molecule.
Claim 11
Dependent Claim
12 words
The fiber-optic sensor of claim 9, wherein the analyte is hydrogen ion.
Claim 12
Dependent Claim
21 words
The fiber-optic sensor of claim 10, wherein the indicator molecule is selected from the group consisting of phenol red and carboxynaphthophthalein.
Claim 13
Dependent Claim
14 words
The fiber-optic sensor of claim 1, wherein the indicator molecule is a luminescent molecule.
Claim 14
Dependent Claim
12 words
The fiber-optic sensor of claim 12, wherein the analyte is hydrogen ion.
Claim 15
Dependent Claim
11 words
The fiber-optic sensor of claim 12, wherein the analyte is oxygen.
Claim 16
Dependent Claim
34 words
The fiber-optic sensor of claim 1, further comprising a gas permeable but ionimpermeable membrane encapsulating the analyte-permeable matrix, the analyte-permeable matrix comprising a base having a pKa ranging from about 6.0 to about 7.8.
Claim 17
Dependent Claim
18 words
The fiber-optic sensor of claim 15, wherein the base has a pKa ranging from about 7.0 to 7.4.
Claim 18
Dependent Claim
25 words
The fiber-optic sensor of claim 15, wherein the gas-permeable but ion-impermeable membrane comprises a resin selected from the group consisting of silicones polycarbonates, and urethanes.
Claim 19
Dependent Claim
22 words
The fiber-optic sensor of claim 15, wherein the base comprises an inorganic salt and wherein the analyte-permeable matrix further comprises an antioxidant.
Claim 20
Dependent Claim
25 words
The fiber-optic sensor of claim 15, wherein the analyte-permeable matrix comprises one or more of the group consisting of poly-N-vinylpyrrolidone, polyethylene glycol, and polyethylene oxide.
Claim 21
Dependent Claim
15 words
The fiber-optic sensor of claim 15, wherein the analyte-permeable matrix comprises approximately 80:20 weight/weight percent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-06-30 | 1995-12-30 | 1996-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-30 | 1999-12-30 | 2000-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-30 | 2003-12-30 | 2004-06-30 | $7700.00 | Window Closed / Lapsed |