US5348533A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pheresis apparatus
Assignee: Haemonetics Corp
•
Filing: 1992-08-27
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Granted: 1994-09-20
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Expires: 2012-08-27
Abstract
Abstract The length of time required to draw, centrifugally separate, harvest blood components and return blood components is reduced by providing a two-arm pheresis system in which blood is drawn from one arm, anticoagulated and pumped into an input reservoir then transferred into a centrifuge bowl for separation, while separated blood components are harvested and returned to the donor from an output reservoir via another arm.
Inventors
- 👤 Jean Papillon
- 👤 Frederick J. York
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 17:20
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3693; A61M1/3621; A61M1/3643; A61M1/3644; A61M1/3696; A61M2205/00; A61M2205/33; A61M2205/3379; A61M2205/3393
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
178 words
Apparatus comprising: a) a draw needle for drawing whole blood from a donor; b) an input buffer in fluid communication with said draw needle via a first conduit; c) a second conduit for fluidly coupling anticoagulant fluid to said first conduit for mixing with said drawn blood; d) a separator for separating drawn blood into at least two fractional components, said separator having an input port and an output port; e) a third conduit for fluidly coupling the input buffer to the input port; f) a component container; g) a fourth conduit for fluidly coupling the output port to said container; h) an output buffer; i) a fifth conduit in fluid communication with said output buffer and said fourth conduit; j) a sixth conduit in fluid communication between said output buffer and said third conduit; k) a return needle in fluid communication with one or more of said output buffer or said component container for transferring fluid therefrom to said donor; and l) a seventh conduit for fluidly coupling said output buffer to a source of physiological solution.
Claim 2
Dependent Claim
178 words
Apparatus comprising: a) a draw needle for drawing whole blood from a donor; b) an input buffer in fluid communication with said draw needle via a first conduit; c) a second conduit for fluidly coupling anticoagulant fluid to said first conduit for mixing with said drawn blood; d) a separator for separating drawn blood into at least two fractional components, said separator having an input port and an output port; e) a third conduit for fluidly coupling the input buffer to the input port; f) a component container; g) a fourth conduit for fluidly coupling the output port to said container; h) an output buffer; i) a fifth conduit in fluid communication with said output buffer and said fourth conduit; j) a sixth conduit in fluid communication between said output buffer and said third conduit; k) a return needle in fluid communication with one or more of said output buffer or said component container for transferring fluid therefrom to said donor; and l) a seventh conduit for fluidly coupling said output buffer to a source of physiological solution.
Claim 3
Dependent Claim
17 words
The apparatus of claim 1 wherein the input buffer, output buffer and component container comprise plastic bags.
Claim 4
Dependent Claim
12 words
The apparatus of claim 1 wherein the separator comprises a centrifuge bowl.
Claim 5
Dependent Claim
26 words
The apparatus of claim 3 wherein the centrifuge bowl is comprised of a stationary input/output section coupled by a rotary seal to a rotating bowl section.
Claim 6
Dependent Claim
35 words
The apparatus of claim 1 including a pump for transferring said separated components and wherein one of the fractional components is plasma and wherein plasma is transferred from the output port to the component container.
Claim 7
Dependent Claim
35 words
The apparatus of claim 1 including a pump for transferring said separated components and wherein one of the fractional components is platelets and wherein platelets are transferred from the output port to the component container.
Claim 8
Dependent Claim
11 words
The apparatus of claim 1 wherein the physiological solution is saline.
Claim 9
Dependent Claim
18 words
The apparatus of claim 1 further including pump means for transferring anticoagulated whole blood into the input buffer.
Claim 10
Dependent Claim
37 words
The apparatus of claim 8 wherein anticoagulated whole blood in the input buffer is transferred by said pump means out of the input buffer to said input port at the same rate it is being transferred in.
Claim 11
Dependent Claim
32 words
The apparatus of claim 9 wherein fluid is transferred by said pump means from the output buffer to the donor at the same rate whole blood is being drawn from said donor.
Claim 12
Dependent Claim
295 words
Apparatus comprising: a) a draw needle for drawing whole blood from a donor; b) an input buffer in fluid communication with said draw needle via a first conduit; c) a second conduit for fluidly coupling anticoagulant fluid to said first conduit for mixing with said drawn blood; d) a separator for separating drawn blood into at least two fractional components, said separator having an input port and an output port; e) a third conduit for fluidly coupling the input buffer to the input port; f) a component container; g) a fourth conduit for fluidly coupling the output port to said container; h) an output buffer; i) a fifth conduit in fluid communication with said output buffer and said fourth conduit; j) a sixth conduit in fluid communication between said output buffer and said third conduit; k) a return needle in fluid communication with one or more of said output buffer or said component container for transferring fluid therefrom to said donor via a seventh conduit; l) a seventh conduit for fluidly coupling said output buffer to a source of physiological solution; m) draw pump means coupled to said first conduit for transferring drawn blood from said draw needle to said input buffer; n) A.C. pump means coupled to said second conduit for transferring anticoagulant from an anticoagulant source to mix with said drawn blood; o) transfer pump means coupled to said third conduit for transferring in a first direction fluid from said input buffer to said input port and in a second direction fluid from said component container to said input port or to said output buffer; and p) return pump means coupled to said seventh conduit for transferring fluid from one or more of said output buffer or said component container to said donor.
Claim 13
Dependent Claim
295 words
Apparatus comprising: a) a draw needle for drawing whole blood from a donor; b) an input buffer in fluid communication with said draw needle via a first conduit; c) a second conduit for fluidly coupling anticoagulant fluid to said first conduit for mixing with said drawn blood; d) a separator for separating drawn blood into at least two fractional components, said separator having an input port and an output port; e) a third conduit for fluidly coupling the input buffer to the input port; f) a component container; g) a fourth conduit for fluidly coupling the output port to said container; h) an output buffer; i) a fifth conduit in fluid communication with said output buffer and said fourth conduit; j) a sixth conduit in fluid communication between said output buffer and said third conduit; k) a return needle in fluid communication with one or more of said output buffer or said component container for transferring fluid therefrom to said donor via a seventh conduit; l) a seventh conduit for fluidly coupling said output buffer to a source of physiological solution; m) draw pump means coupled to said first conduit for transferring drawn blood from said draw needle to said input buffer; n) A.C. pump means coupled to said second conduit for transferring anticoagulant from an anticoagulant source to mix with said drawn blood; o) transfer pump means coupled to said third conduit for transferring in a first direction fluid from said input buffer to said input port and in a second direction fluid from said component container to said input port or to said output buffer; and p) return pump means coupled to said seventh conduit for transferring fluid from one or more of said output buffer or said component container to said donor.
Claim 14
Dependent Claim
17 words
The apparatus of claim 11 wherein the input buffer, output buffer and component container comprise plastic bags.
Claim 15
Dependent Claim
12 words
The apparatus of claim 11 wherein the separator comprises a centrifuge bowl.
Claim 16
Dependent Claim
26 words
The apparatus of claim 13 wherein the centrifuge bowl is comprised of a stationary input/output section coupled by a rotary seal to a rotating bowl section.
Claim 17
Dependent Claim
35 words
The apparatus of claim 11 including a pump for transferring said separated components and wherein one of the fractional components is plasma and wherein plasma is transferred from the output port to the component container.
Claim 18
Dependent Claim
35 words
The apparatus of claim 11 including a pump for transferring said separated components and wherein one of the fractional components is platelets and wherein platelets are transferred from the output port to the component container.
Claim 19
Dependent Claim
11 words
The apparatus of claim 11 wherein the physiological solution is saline.
Claim 20
Dependent Claim
18 words
The apparatus of claim 11 further including pump means for transferring anticoagulated whole blood into the input buffer.
Claim 21
Dependent Claim
37 words
The apparatus of claim 18 wherein anticoagulated whole blood in the input buffer is transferred by said pump means out of the input buffer to said input port at the same rate it is being transferred in.
Claim 22
Dependent Claim
32 words
The apparatus of claim 19 wherein fluid is transferred by said pump means from the output buffer to the donor at the same rate whole blood is being drawn from said donor.
Claim 23
Independent Claim
273 words
A method for separating whole blood collected from a donor via a draw needle into constituent components and returning some of the separated components via a return needle in a centrifugal separation system comprised of a centrifuge having a stator and a rotatable bowl with the stator having an input port fluidly coupled on one side to an input reservoir and on another side to the interior of the bowl and an output port fluidly coupled on one side to the interior of the bowl and on another side to an output reservoir and a component container; comprising the steps of: a) priming the system by transferring a volume of physiological solution from a solution bag into the output reservoir and transferring a volume of anticoagulant from an anticoagulant bag into the input reservoir and pumping some of the solution in the output reservoir to the return needle by a return pump; b) drawing blood from the donor via the draw needle and mixing the blood with anticoagulant and transferring the anticoagulant drawn blood into the input reservoir by a draw pump; c) transferring the physiological fluid from the output reservoir by the return pump into the donor via the return phlebotomy needle; and d) transferring the anticoagulated whole blood from the input reservoir to the input port of the bowl by a transfer pump causing some blood component(s) to be separated in the bowl and to exit the bowl and enter a component container for harvesting while other separated component(s) are transferred to said output reservoir; and e) transferring fluid from the output reservoir to the donor via the return phlebotomy needle.
Claim 24
Independent Claim
273 words
A method for separating whole blood collected from a donor via a draw needle into constituent components and returning some of the separated components via a return needle in a centrifugal separation system comprised of a centrifuge having a stator and a rotatable bowl with the stator having an input port fluidly coupled on one side to an input reservoir and on another side to the interior of the bowl and an output port fluidly coupled on one side to the interior of the bowl and on another side to an output reservoir and a component container; comprising the steps of: a) priming the system by transferring a volume of physiological solution from a solution bag into the output reservoir and transferring a volume of anticoagulant from an anticoagulant bag into the input reservoir and pumping some of the solution in the output reservoir to the return needle by a return pump; b) drawing blood from the donor via the draw needle and mixing the blood with anticoagulant and transferring the anticoagulant drawn blood into the input reservoir by a draw pump; c) transferring the physiological fluid from the output reservoir by the return pump into the donor via the return phlebotomy needle; and d) transferring the anticoagulated whole blood from the input reservoir to the input port of the bowl by a transfer pump causing some blood component(s) to be separated in the bowl and to exit the bowl and enter a component container for harvesting while other separated component(s) are transferred to said output reservoir; and e) transferring fluid from the output reservoir to the donor via the return phlebotomy needle.
Claim 25
Dependent Claim
20 words
The method of claim 21 wherein the input reservoir, output reservoir and component container are formed of disposable plastic bags.
Claim 26
Dependent Claim
12 words
The method of claim 21 wherein the transferring is performed by pumps.
Claim 27
Dependent Claim
12 words
The method of claim 21 wherein the pumps are peristaltic type pumps.
Claim 28
Dependent Claim
35 words
The method of claim 21 including a pump for transferring said separated components and wherein one of the fractional components is plasma and wherein plasma is transferred from the output port to the component container.
Claim 29
Dependent Claim
35 words
The method of claim 21 including a pump for transferring said separated components and wherein one of the fractional components is platelets and wherein platelets are transferred from the output port to the component container.
Claim 30
Dependent Claim
11 words
The method of claim 21 wherein the physiological solution is saline.
Claim 31
Dependent Claim
18 words
The method of claim 21 further including pump means for transferring anticoagulated whole blood into the input reservoir.
Claim 32
Dependent Claim
33 words
The method of claim 21 wherein anticoagulated whole blood in the input reservoir is transferred out of the input reservoir to said input port at the same rate it is being transferred in.
Claim 33
Dependent Claim
28 words
The method of claim 21 wherein fluid is transferred from the output reservoir to the donor at the same rate whole blood is being drawn from said donor.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-09-19 | 1998-03-21 | 1998-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-19 | 2002-03-21 | 2002-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-19 | 2006-03-21 | 2006-09-20 | $7700.00 | Window Closed / Lapsed |