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US5340568A
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Topical composition and method containing deoxy and halo derivatives of lysophosphatidic acids for regulating skin wrinkles
Assignee: Procter and Gamble Co
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Filing: 1992-07-01
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Granted: 1994-08-23
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Expires: 2012-07-01
Abstract
Abstract The subject invention relates to compositions and methods for regulating wrinkles in mammalian skin by topical application of a 2-deoxy- or 2-deoxy-2-halo-lysophosphatidic acid compound having the structure: ##STR1## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms; each --X-- is independently --0-- or --S--; --Y-- is --0-- or --CH 2 --; and Z is --H or halo.
Inventors
- 👤 Gary A. Piazza
- 👤 Adam W. Mazur
- 👤 Gerald B. Kasting
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 00:52
CPC Classifications
A; A61; A61Q; A61Q19/00; A61Q19/08; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/37; A61K8/49; A61K8/4973; A61K8/55; A61K8/553; A61K8/72; A61K8/81; A61K8/8141; A61K8/8152; A61Q17/00; A61Q17/04; Y; Y10; Y10S; Y10S424/00; Y10S424/05
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
104 words
A composition for topical application for preventing, retarding, arresting or reversing the process of wrinkle formation in mammalian skin comprising: (a) a safe and effective amount of a 2-deoxy- or 2-deoxy-2-halo-lysophosphatidic acid compound having the structure: ##STR4## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, with a substituent selected from the group consisting of halogen, hydroxy, phenyl, amino and acylamino, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms; each --X-- independently --O-- or --S--; --Y-- is --O-- or --CH 2 ; and --Z is --H or halo; and (b) a topical carrier.
Claim 2
Dependent Claim
104 words
A composition for topical application for preventing, retarding, arresting or reversing the process of wrinkle formation in mammalian skin comprising: (a) a safe and effective amount of a 2-deoxy- or 2-deoxy-2-halo-lysophosphatidic acid compound having the structure: ##STR4## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, with a substituent selected from the group consisting of halogen, hydroxy, phenyl, amino and acylamino, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms; each --X-- independently --O-- or --S--; --Y-- is --O-- or --CH 2 ; and --Z is --H or halo; and (b) a topical carrier.
Claim 3
Dependent Claim
25 words
The composition of claim 1 wherein the composition comprises from about 0.01% to about 20% of the compound, and the topical carrier comprises an emollient.
Claim 4
Dependent Claim
15 words
The composition of claim 2 wherein --R is unsubstituted or substituted with hydroxy or halogen.
Claim 5
Dependent Claim
14 words
The composition of claim 3 wherein each --X-- is --O--, and --Y-- is --O--.
Claim 6
Dependent Claim
26 words
The composition of claim 4 wherein --R is unsubstituted, straight-chain having from about 11 to 17 carbon atoms, and saturated or unsaturated with one double bond.
Claim 7
Dependent Claim
11 words
The composition of claim 5 wherein Z is --Cl or --F.
Claim 8
Dependent Claim
24 words
The composition of claim 6 wherein --Z is --F; and RC(O)O-- is selected from the group consisting of oleyl, palmitoleyl, palmityl, myristyl and lauryl.
Claim 9
Dependent Claim
18 words
The composition of claim 6 wherein the composition comprises from about 0.1% to about 5% of the compound.
Claim 10
Dependent Claim
22 words
The composition of claim 2 or 6 wherein the composition also comprises from about 1% to about 20% of a sunscreen agent.
Claim 11
Independent Claim
108 words
A method of preventing, retarding, arresting or reversing the process of wrinkle formation in mammalian skin comprising topically applying to the skin of a mammal a composition comprising a safe and effective amount of a 2-deoxy- or 2-deoxy-2-halo-lysophosphatidic acid compound having the structure: ##STR5## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted with a substituent selected from the group consisting of halogen, hydroxy, phenyl, amino and acylamino, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms; each 13 X-- is independently --O-- or --S--; --Y-- is --O-- or --CH 2 --; and Z is --H or halo.
Claim 12
Independent Claim
108 words
A method of preventing, retarding, arresting or reversing the process of wrinkle formation in mammalian skin comprising topically applying to the skin of a mammal a composition comprising a safe and effective amount of a 2-deoxy- or 2-deoxy-2-halo-lysophosphatidic acid compound having the structure: ##STR5## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted with a substituent selected from the group consisting of halogen, hydroxy, phenyl, amino and acylamino, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms; each 13 X-- is independently --O-- or --S--; --Y-- is --O-- or --CH 2 --; and Z is --H or halo.
Claim 13
Dependent Claim
20 words
The method of claim 10 wherein --R is unsubstituted or substituted with hydroxy or halogen, and each --X-- is --O--.
Claim 14
Dependent Claim
34 words
The method of claim 11 wherein --Z is --Cl or --F; and --R is unsubstituted, straight chain, saturated or unsaturated with one double bond, and has from about 11 to about 17 carbon atoms.
Claim 15
Dependent Claim
9 words
The method of claim 12 wherein --Y-- is --O--.
Claim 16
Dependent Claim
34 words
The method of claim 10 or 13 wherein the amount of the 2-deoxy- or 2-deoxy-2-halo-lysophosphatidic acid compound applied to the skin is from about 0.01 mg to about 1 mg per cm 2 skin.
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