Patent US2014313A successfully refreshed from Google Patents.
Patent US5334640A successfully refreshed from Google Patents.
US5334640A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
Assignee: RENEURON Inc
•
Filing: 1992-04-08
•
Granted: 1994-08-02
•
Expires: 2012-04-08
Abstract
Abstract Crosslinked biocompatible compositions comprising an ionically crosslinked component and a covalently crosslinked component for encapsulating biologics are disclosed. In accordance with the present invention, also disclosed are crosslinkable biocompatible mixtures comprising an ionically crosslinkable component and a covalently crosslinkable component. Methods for encapsulating biologics with the crosslinked and crosslinkable biocompatible compositions are provided. Also, retrievable macrocapsules for encapsulating microcapsules or biologics are disclosed.
Inventors
- 👤 Neil P. Desai
- 👤 Patrick Soon-Shiong
- 👤 Paul A. Sandford
- 👤 Roswitha E. Heintz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:55
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; C12N11/04; A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; C08; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/329; C08G65/331; C08G65/332; C08L; C08L5/00; C08L5/04; C08L71/00; C08L71/02; C12N5/00; C12N5/0012; C12N2533/00; C12N2533/30; C12N2533/70; C12N2533/74
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
33 words
A crosslinked biocompatible material comprising: at least one ionically crosslinked component; and at least one covalently crosslinked component, wherein the ionically crosslinked component is selected from a polysaccharide, a polyanion, or a polycation.
Claim 2
Dependent Claim
33 words
A crosslinked biocompatible material comprising: at least one ionically crosslinked component; and at least one covalently crosslinked component, wherein the ionically crosslinked component is selected from a polysaccharide, a polyanion, or a polycation.
Claim 3
Dependent Claim
14 words
The crosslinked biocompatible material of claim 1, wherein the ionically crosslinked component is alginate.
Claim 4
Dependent Claim
22 words
The crosslinked biocompatible material of claim 2, wherein the alginate is a high G block alginate having at least 60% α-L-guluronic acid.
Claim 5
Dependent Claim
16 words
The crosslinked biocompatible material of claim 3, wherein the alginate comprises at least 70% α-L-guluronic acid.
Claim 6
Dependent Claim
15 words
The crosslinked biocompatible material of claim 2, further comprising a biologic encapsulated by the material.
Claim 7
Dependent Claim
22 words
The crosslinked biocompatible material of claim 5, wherein the material is effective to provide immunoprotection for the biologic in a physiological environment.
Claim 8
Dependent Claim
17 words
The crosslinked biocompatible material of claim 6, wherein the material provides immunoprotection of the biologic when xenotransplanted.
Claim 9
Dependent Claim
19 words
The crosslinked biocompatible material of claim 5, wherein the biologic is a biologically active material or a diagnostic marker.
Claim 10
Dependent Claim
41 words
The crosslinked biocompatible material of claim 8, wherein the biologically active materials are living cells selected from islets of Langerhans, dopamine secreting cells, erythropoietin secreting cells, nerve growth factor secreting cells, hepatocytes, adrenaline/angiotensin secreting cells, parathyroid cells, or norepinephrine/metacephalin secreting cells.
Claim 11
Dependent Claim
15 words
The crosslinked biocompatible material of claim 8, wherein the biologically active material is a drug.
Claim 12
Dependent Claim
29 words
A crosslinked biocompatible material comprising: at least one ionically crosslinked component; and at least one covalently crosslinked component, wherein the covalently crosslinked component is derived from a polyalkylene oxide.
Claim 13
Dependent Claim
29 words
A crosslinked biocompatible material comprising: at least one ionically crosslinked component; and at least one covalently crosslinked component, wherein the covalently crosslinked component is derived from a polyalkylene oxide.
Claim 14
Dependent Claim
16 words
The crosslinked biocompatible material of claim 11, wherein the covalently crosslinked component is polyethylene glycol diacrylate.
Claim 15
Dependent Claim
15 words
The crosslinked biocompatible material of claim 11, further comprising a biologic encapsulated by the material.
Claim 16
Dependent Claim
22 words
The crosslinked biocompatible material of claim 13, wherein the material is effective to provide immunoprotection for the biologic in a physiological environment.
Claim 17
Dependent Claim
17 words
The crosslinked biocompatible material of claim 14, wherein the material provides immunoprotection of the biologic when xenotransplanted.
Claim 18
Dependent Claim
19 words
The crosslinked biocompatible material of claim 13, wherein the biologic is a biologically active material or a diagnostic marker.
Claim 19
Dependent Claim
41 words
The crosslinked biocompatible material of claim 16, wherein the biologically active materials are living cells selected from islets of Langerhans, dopamine secreting cells, erythropoietin secreting cells, nerve growth factor secreting cells, hepatocytes, adrenaline/angiotensin secreting cells, parathyroid cells, or norepinephrine/metacephalin secreting cells.
Claim 20
Dependent Claim
15 words
The crosslinked biocompatible material of claim 16, wherein the biologically active material is a drug.
Claim 21
Dependent Claim
33 words
A crosslinkable biocompatible mixture comprising: at least one ionically crosslinkable component; and at least one covalently crosslinkable component, wherein the ionically crosslinkable component is selected from a polysaccharide, a polyanion, or a polycation.
Claim 22
Dependent Claim
33 words
A crosslinkable biocompatible mixture comprising: at least one ionically crosslinkable component; and at least one covalently crosslinkable component, wherein the ionically crosslinkable component is selected from a polysaccharide, a polyanion, or a polycation.
Claim 23
Dependent Claim
14 words
The crosslinkable biocompatible mixture of claim 19, wherein the ionically crosslinkable component is alginate.
Claim 24
Dependent Claim
22 words
The crosslinkable biocompatible mixture of claim 20, wherein the alginate is capable of ionically crosslinking by adding multivalent cations to the mixture.
Claim 25
Dependent Claim
37 words
The crosslinkable biocompatible mixture of claim 19, wherein the composition ratio between the ionically crosslinkable component and the covalently crosslinkable component is effective for the stable crosslinking of the mixture, whereby a gelled encapsulation material is formed.
Claim 26
Dependent Claim
35 words
The crosslinkable biocompatible mixture of claim 22, wherein the concentration and the molecular weight(s) of the covalently crosslinkable component are effective to provide immunoprotection to the encapsulated functional core once the mixture has been crosslinked.
Claim 27
Dependent Claim
21 words
The crosslinkable biocompatible mixture of claim 23, wherein the mixture has an osmolarity and pH compatible with living tissue or cells.
Claim 28
Dependent Claim
25 words
The crosslinkable biocompatible mixture of claim 24, wherein the osmolarity of the mixture is about 290 milliosmoles per kilogram and the pH is about 7.4.
Claim 29
Dependent Claim
38 words
The crosslinkable biocompatible mixture of claim 23, wherein the concentration and molecular weight(s) of the covalently crosslinkable component are effective for the controlled release of the biologic or components of the biologic once the mixture has been crosslinked.
Claim 30
Dependent Claim
27 words
A crosslinkable biocompatible mixture comprising: at least one ionically crosslinkable component; and at least one covalently crosslinkable component, wherein the covalently crosslinkable component is a polyalkylene oxide.
Claim 31
Dependent Claim
27 words
A crosslinkable biocompatible mixture comprising: at least one ionically crosslinkable component; and at least one covalently crosslinkable component, wherein the covalently crosslinkable component is a polyalkylene oxide.
Claim 32
Dependent Claim
20 words
The crosslinkable biocompatible mixture of claim 27, wherein the polyalkylene oxide is capable of covalently crosslinking by free radical polymerization.
Claim 33
Dependent Claim
15 words
The crosslinkable biocompatible mixture of claim 27, wherein the polyalkylene oxide is polyethylene glycol diacrylate.
Claim 34
Dependent Claim
37 words
The crosslinkable biocompatible mixture of claim 27, wherein the composition ratio between the ionically crosslinkable component and the covalently crosslinkable component is effective for the stable crosslinking of the mixture, whereby a gelled encapsulation material is formed.
Claim 35
Dependent Claim
35 words
The crosslinkable biocompatible mixture of claim 30, wherein the concentration and the molecular weight(s) of the covalently crosslinkable component are effective to provide immunoprotection to the encapsulated functional core once the mixture has been crosslinked.
Claim 36
Dependent Claim
21 words
The crosslinkable biocompatible mixture of claim 31, wherein the mixture has an osmolarity and pH compatible with living tissue or cells.
Claim 37
Dependent Claim
25 words
The crosslinkable biocompatible mixture of claim 32, wherein the osmolarity of the mixture is about 290 milliosmoles per kilogram and the pH is about 7.4.
Claim 38
Dependent Claim
38 words
The crosslinkable biocompatible mixture of claim 31, wherein the concentration and molecular weight(s) of the covalently crosslinkable component are effective for the controlled release of the biologic or components of the biologic once the mixture has been crosslinked.
Claim 39
Dependent Claim
32 words
A retrievable implantation material, comprising: a crosslinked biocompatible macrocapsule comprising at least one ionically crosslinked component, and at least one covalently crosslinked component, whereby said macrocapsule encapsulates a microcapsule(s) or a biologic.
Claim 40
Dependent Claim
32 words
A retrievable implantation material, comprising: a crosslinked biocompatible macrocapsule comprising at least one ionically crosslinked component, and at least one covalently crosslinked component, whereby said macrocapsule encapsulates a microcapsule(s) or a biologic.
Claim 41
Dependent Claim
20 words
The retrievable implantation material of claim 35, wherein the macrocapsule provides immunoprotection to the encapsulated microcapsule(s) or biologic when xenotransplanted.
References Cited (Backward Citations)
US4177038A
Cited
US4352883A
Cited
US4391909A
Cited
US4409331A
Cited
US4798786A
Cited
US4663286A
Cited
US4744933A
Cited
US4749620A
Cited
US4824916A
Cited
US4592098A
Cited
US4791061A
Cited
US5041292A
Cited
GB2237574A
Cited
WO1991007951A1
Cited
WO1991009119A1
Cited
WO1991011205A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-08-01 | 1998-01-31 | 1998-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-01 | 2002-01-31 | 2002-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-08-01 | 2006-01-31 | 2006-08-02 | $7700.00 | Window Closed / Lapsed |