US5310686A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymer-coated optical structures
Assignee: Applied Research Systems ARS Holding NV
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Filing: 1988-03-09
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Granted: 1994-05-10
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Expires: 2008-03-09
Abstract
Abstract A method is disclosed for coating the surface of an optical structure, such as a diffraction grating, useful for the detection of a ligand, which method comprises forming on the surface of the optical structure a thin, uniform layer of a polymerizable material, particularly one which polymerizes on exposure to light or heat, and subsequently exposing said material to polymerizing conditions. A specific binding partner is subsequently absorbed on or bound to the cured polymer layer, either directly or indirectly. Complex formation between the specific binding partner and ligand present in the sample to be analyzed alters the optical properties of the device and the change forms the basis of an assay.
Inventors
- 👤 Craig G. Sawyers
- 👤 Rosemary A. L. Drake
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:06
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/55; G01N21/552; G01N21/553; G01N21/47; G01N21/4788; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/543; G01N33/54366; G01N33/54373; G01N33/544; G01N33/545; G01N33/551; G01N33/553; Y; Y10; Y10S; Y10S436/00; Y10S436/805
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
75 words
A method of preparing a diffraction grating useful for the detection of a ligand comprising (a) applying a metered volume of a polymerizable material to the surface of said diffraction grating and spinning said diffraction grating to distribute said polymerizable material as a thin, uniform layer over the surface thereof; (b) polymerizing said material; and (c) adsorbing on or binding to said polymerized material, either directly or indirectly, a specific binding partner for said ligand.
Claim 2
Independent Claim
75 words
A method of preparing a diffraction grating useful for the detection of a ligand comprising (a) applying a metered volume of a polymerizable material to the surface of said diffraction grating and spinning said diffraction grating to distribute said polymerizable material as a thin, uniform layer over the surface thereof; (b) polymerizing said material; and (c) adsorbing on or binding to said polymerized material, either directly or indirectly, a specific binding partner for said ligand.
Claim 3
Dependent Claim
15 words
A method according to claim 1 wherein said diffraction grating is a metallized diffraction grating.
Claim 4
Dependent Claim
17 words
A method according to claim 2 wherein said diffraction grating is capable of exhibiting surface plasmon resonance.
Claim 5
Dependent Claim
17 words
A method according to claim 1 wherein said specific binding partner is an antigen or an antibody.
Claim 6
Dependent Claim
25 words
A method according to claim 1 wherein said polymerizable material comprises a negative photoresist and said polymerizing is conducted by exposing said material to light.
Claim 7
Dependent Claim
13 words
A method according to claim 5 wherein said negative photoresist comprises cyclized cis-1,4-polyisoprene.
Claim 8
Dependent Claim
25 words
A method according to claim 3 wherein said polymerizable material comprises a negative photoresist and said polymerizing is conducted by exposing said material to light.
Claim 9
Dependent Claim
13 words
A method according to claim 7 wherein said negative photoresist comprises cyclized cis-1,4-polyisoprene.
Claim 10
Dependent Claim
15 words
A method according to claim 1 wherein said polymerized material is to 200 nanometers thick.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-05-09 | 1997-11-08 | 1998-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-05-09 | 2001-11-08 | 2002-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-05-09 | 2005-11-08 | 2006-05-10 | $7700.00 | Window Closed / Lapsed |