US5300289A
Expired / Lapsed
US
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Phytate antimicrobial compositions in oral care products
Assignee: Dow Chemical Co
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Filing: 1991-12-10
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Granted: 1994-04-05
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Expires: 2011-12-10
Abstract
Abstract Oral compositions containing phytic acid or a physiologically acceptable salt thereof, a cationic antimicrobial compound and a compatibilizing agent are disclosed for controlling dental calculus, dental plaque, gingivitis, periodontitis and/or oral malodor.
Inventors
- 👤 Joseph R. Garlich
- 👤 Tipton T. Masterson
- 👤 R. Keith Frank
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:24
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/55; A61K8/40; A61K8/41; A61K8/416; A61K8/49; A61K8/4906; A61K8/4926; A61Q; A61Q11/00
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
139 words
An oral composition consisting essentially of: (1) from about 0.001 to about 10 percent by weight of one or more compounds having C-O-P bonds wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate), myo-inositol pentakis(dihydrogen phosphate), myo-inositol tetrakis(dihydrogen phosphate) or physiologically acceptable salts thereof; (2) from about 0.001 to about 10 percent by weight of one or more cationic antimicrobial compounds with the proviso that the cationic antimicrobial compounds are other than the chlorhexidine, alexidine or a cationic bisbiguanide compound; (3) from about 0.1 to about 20 percent by weight of a compatibilizing agent and (4) the remaining percent by weight is an orally acceptable vehicle having a pH in the range of about 4.5 to about 9 wherein the compatibilizing agent prevents the phytic acid and antimicrobial compound from forming a precipitate when in an aqueous environment.
Claim 2
Dependent Claim
139 words
An oral composition consisting essentially of: (1) from about 0.001 to about 10 percent by weight of one or more compounds having C-O-P bonds wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate), myo-inositol pentakis(dihydrogen phosphate), myo-inositol tetrakis(dihydrogen phosphate) or physiologically acceptable salts thereof; (2) from about 0.001 to about 10 percent by weight of one or more cationic antimicrobial compounds with the proviso that the cationic antimicrobial compounds are other than the chlorhexidine, alexidine or a cationic bisbiguanide compound; (3) from about 0.1 to about 20 percent by weight of a compatibilizing agent and (4) the remaining percent by weight is an orally acceptable vehicle having a pH in the range of about 4.5 to about 9 wherein the compatibilizing agent prevents the phytic acid and antimicrobial compound from forming a precipitate when in an aqueous environment.
Claim 3
Dependent Claim
116 words
The composition of claim 1 wherein the cationic antimicrobial compound is one or more quaternary ammonium compounds selected from the group consisting of formula I ##STR14## and a mixture thereof; wherein R 1 is a C 8 -C 20 alkyl, R 2 is benzyl or C 1 -C 12 alkyl, R 3 and R 4 are independently a C 1 -C 7 alkyl or --(CH 2 --CHOH--CH 2 --O) n H wherein n is an integer from 1 to 6, R 5 is --H, a C 1 -C 7 alkyl or --(CH 2 --CHOH--CH 2 --O) n H wherein n is an integer from 1 to 6, and X -- is chloride, bromide, iodide or fluoride.
Claim 4
Dependent Claim
21 words
The composition of claim 1 wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate) or a physiologically acceptable salt thereof.
Claim 5
Dependent Claim
24 words
The composition of claim 3 wherein the cationic antimicrobial compound is a quaternary ammonium compound represented by Formula II as defined in claim 2.
Claim 6
Dependent Claim
13 words
The composition of claim 4 wherein the quaternary ammonium compound is cetylpyridinium chloride.
Claim 7
Dependent Claim
13 words
The composition of claim 4 wherein the quaternary ammonium compound is N-tetradecyl-4-ethylpyridinium chloride.
Claim 8
Dependent Claim
28 words
The composition of claim 1 wherein the compatibilizing agent an anionic buffer, wherein the anionic buffer is phosphate, acetate, borate, citrate, bicarbonate, gluconate, tartrate, sulfate or mixtures thereof.
Claim 9
Dependent Claim
16 words
The composition of claim 7 wherein the anionic buffer is phosphate, bicarbonate or a mixture thereof.
Claim 10
Dependent Claim
47 words
The composition of claim 8 wherein the orally acceptable vehicle contains from about 70 to about 99.9 percent by weight water or an alcohol-water mixture wherein the C-O-P compound is myo-inositol hexakis(dihydrogen phosphate) or a physiologically acceptable salt thereof and the cationic antimicrobial compound is cetylpyridinium chloride.
Claim 11
Independent Claim
153 words
A method of inhibiting dental calculus comprising administering to mammalian teeth a calculus-inhibiting amount of an anticalculus oral composition consisting essentially of: (1) about 0.001 to about 10 percent by weight of one or more compounds having C-O-P bonds wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate), myo-inositol pentakis(dihydrogen phosphate), myo-inositol tetrakis(dihydrogen phosphate) or physiologically acceptable salts thereof; (2) from about 0.001 to about 10 percent by weight of one or more cationic antimicrobial compounds with the proviso that the cationic antimicrobial compounds are other than chlorhexidine, alexidine or a cationic bisbiguanide compound; (3) from about 0.1 to about 20 percent by weight of a compatibilizing agent and (4) the remaining percent by weight is an orally acceptable vehicle having a pH in the range of about 4.5 to about 9 wherein the compatibilizing agent prevents the phytic acid and antimicrobial compound from forming a precipitate when in an aqueous environment.
Claim 12
Independent Claim
153 words
A method of inhibiting dental calculus comprising administering to mammalian teeth a calculus-inhibiting amount of an anticalculus oral composition consisting essentially of: (1) about 0.001 to about 10 percent by weight of one or more compounds having C-O-P bonds wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate), myo-inositol pentakis(dihydrogen phosphate), myo-inositol tetrakis(dihydrogen phosphate) or physiologically acceptable salts thereof; (2) from about 0.001 to about 10 percent by weight of one or more cationic antimicrobial compounds with the proviso that the cationic antimicrobial compounds are other than chlorhexidine, alexidine or a cationic bisbiguanide compound; (3) from about 0.1 to about 20 percent by weight of a compatibilizing agent and (4) the remaining percent by weight is an orally acceptable vehicle having a pH in the range of about 4.5 to about 9 wherein the compatibilizing agent prevents the phytic acid and antimicrobial compound from forming a precipitate when in an aqueous environment.
Claim 13
Dependent Claim
115 words
The method of claim 10 wherein the cationic antimicrobial compound is one or more quaternary ammonium compounds selected from the group consisting of formula I ##STR15## and a mixture thereof; wherein R 1 is a C 8 -C 20 alkyl, R 2 is benzyl or C 1 -C 12 alkyl, R 3 and R 4 are independently a C 1 -C 7 alkyl or --(CH 2 --CHOH--CH 2 --O) n H wherein n is an integer from 1 to 6, R 5 is --H, a C 1 -C 7 alkyl or --(CH 2 --CHOH--CH 2 --O) n H wherein n is an integer from 1 to 6, and X-- is chloride, bromide, iodide or fluoride.
Claim 14
Dependent Claim
21 words
The method of claim 10 wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate) or a physiologically acceptable salt thereof.
Claim 15
Dependent Claim
24 words
The method of claim 12 wherein the cationic antimicrobial compound is a quaternary ammonium compound represented by Formula II as defined in claim 11.
Claim 16
Dependent Claim
13 words
The method of claim 13 wherein the quaternary ammonium compound is cetylpyridinium chloride.
Claim 17
Dependent Claim
13 words
The method of claim 13 wherein the quaternary ammonium compound is N-tetradecyl-4-ethylpyridinium chloride.
Claim 18
Dependent Claim
29 words
The method of claim 10 wherein the compatibilizing agent is an anionic buffer, wherein the anionic buffer is phosphate, acetate, borate, citrate, bicarbonate, gluconate, tartrate, sulfate or mixtures thereof.
Claim 19
Dependent Claim
16 words
The method of claim 16 wherein the anionic buffer is phosphate, bicarbonate or a mixture thereof.
Claim 20
Dependent Claim
49 words
The method of claim 17 wherein the orally acceptable vehicle contains from about 70 to about 99.9 percent by weight water or an alcohol-water mixture wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate) or a physiologically acceptable salt thereof and the cationic antimicrobial compound is cetylpyridinium chloride.
Claim 21
Independent Claim
157 words
A method of inhibiting dental plaque and/or oral malodor comprising administering to mammalian teeth a plaque-inhibiting amount of an antiplaque oral composition consisting essentially of: (1) from about 0.001 to about 10 percent by weight of one or more compounds having C-O-P bonds wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate), myo-inositol pentakis(dihydrogen phosphate), myo-inositol tetrakis(dihydrogen phosphate) or physiologically acceptable salts thereof; (2) from about 0.001 to about 10 percent by weight of one or more cationic antimicrobial compounds with the proviso that the cationic antimicrobial compounds are other than chlorhexidine, alexidine or a cationic bisbiguanide compound; (3) from about 0.1 to about 20 percent by weight of a compatibilizing agent and (4) the remaining percent by weight is an orally acceptable vehicle having a pH in the range of about 4.5 to about 9 wherein the compatibilizing agent prevents the phytic acid and antimicrobial compound from forming a precipitate when in an aqueous environment.
Claim 22
Independent Claim
157 words
A method of inhibiting dental plaque and/or oral malodor comprising administering to mammalian teeth a plaque-inhibiting amount of an antiplaque oral composition consisting essentially of: (1) from about 0.001 to about 10 percent by weight of one or more compounds having C-O-P bonds wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate), myo-inositol pentakis(dihydrogen phosphate), myo-inositol tetrakis(dihydrogen phosphate) or physiologically acceptable salts thereof; (2) from about 0.001 to about 10 percent by weight of one or more cationic antimicrobial compounds with the proviso that the cationic antimicrobial compounds are other than chlorhexidine, alexidine or a cationic bisbiguanide compound; (3) from about 0.1 to about 20 percent by weight of a compatibilizing agent and (4) the remaining percent by weight is an orally acceptable vehicle having a pH in the range of about 4.5 to about 9 wherein the compatibilizing agent prevents the phytic acid and antimicrobial compound from forming a precipitate when in an aqueous environment.
Claim 23
Dependent Claim
116 words
The method of claim 19 wherein the cationic antimicrobial compound is one or more quaternary ammonium compounds selected from the group consisting of Formula I ##STR16## and a mixture thereof; wherein R 1 is a C 8 -C 20 alkyl, R 2 is benzyl or C 1 -C 12 alkyl, R 3 and R 4 are independently a C 1 -C 7 alkyl or --(CH 2 --CHOH--CH 2 --O) n H wherein n is an integer from 1 to 6, R 5 is --H, a C 1 -C 7 alkyl or --(CH 2 --CHOH--CH 2 --O) n H wherein n is an integer from 1 to 6, and X -- is chloride, bromide, iodide or fluoride.
Claim 24
Dependent Claim
21 words
The method of claim 19 wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate) or a physiologically acceptable salt thereof.
Claim 25
Dependent Claim
24 words
The method of claim 21 wherein the cationic antimicrobial compound is a quaternary ammonium compound represented by Formula II as defined in claim 20.
Claim 26
Dependent Claim
13 words
The method of claim 22 wherein the quaternary ammonium compound is cetylpyridinium chloride.
Claim 27
Dependent Claim
13 words
The method of claim 22 wherein the quaternary ammonium compound is N-tetradecyl-4-ethylpyridinium chloride.
Claim 28
Dependent Claim
29 words
The method of claim 19 wherein the compatibilizing agent is an anionic buffer, wherein the anionic buffer is phosphate, acetate, borate, citrate, bicarbonate, gluconate, tartrate, sulfate or mixtures thereof.
Claim 29
Dependent Claim
16 words
The method of claim 25 wherein the anionic buffer is phosphate, bicarbonate or a mixture thereof.
Claim 30
Dependent Claim
33 words
The method of claim 26 wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate) or a physiologically acceptable salt thereof, the cationic antimicrobial compound is cetylpyridinium chloride and the buffer is phosphate.
Claim 31
Dependent Claim
25 words
The method of claim 27 wherein the orally acceptable vehicle contains from about 70 to about 99.9 percent by weight water or an alcohol-water mixture.
Claim 32
Dependent Claim
33 words
The method of claim 26 wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate) or a physiologically acceptable salt thereof, the cationic antimicrobial compound is cetylpyridinium chloride and the buffer is bicarbonate.
Claim 33
Dependent Claim
25 words
The method of claim 29 wherein the orally acceptable vehicle contains from about 70 to about 99.9 percent by weight water or an alcohol-water mixture.
Claim 34
Dependent Claim
53 words
The method of claim 26 wherein the orally acceptable vehicle contains from about 70 to about 99.9 percent by weight water or an alcohol-water mixture wherein the compound having C-O-P bonds is myo-inositol hexakis(dihydrogen phosphate) or a physiologically acceptable salt thereof, the cationic antimicrobial compound is cetylpyridinium chloride, and the buffer is bicarbonate.
Claim 35
Dependent Claim
72 words
A process for preparing an oral composition as defined in claim 1 comprising the steps of (a) dissolving the compound having C-O-P bonds and the compatibilizing agent in water; and (b) dissolving the cationic antimicrobial compound or a solution of the cationic antimicrobial compound in the solution obtained from step a, wherein the pH of the solution is adjusted to between about 6 and about 8 after step a or step b.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-04-04 | 1997-10-04 | 1998-04-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-04-04 | 2001-10-04 | 2002-04-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-04-04 | 2005-10-04 | 2006-04-05 | $7700.00 | Window Closed / Lapsed |