US4335102A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oral composition for caries prophylaxis
Assignee: Lion Corp
•
Filing: 1980-09-09
•
Granted: 1982-06-15
•
Expires: 2000-09-09
Abstract
Abstract An oral composition for caries prophylaxis which comprises a highly soluble stannous compound such as stannous fluoride preferably in an amount of 0.03 to 5% by weight of the composition as stannous tin, a difficultly soluble stannous compound such as stannous pyrophosphate preferably in an amount of 0.05 to 10% by weight of the composition as stannous tin, a phytic acid compound such as sodium phytate preferably in an amount of 0.1 to 20% by weight of the composition, and the pH of the composition being preferably acidic. A portion of the difficultly soluble stannous compound may be in a precipitate form. The oral composition which may be used as dentifrices, prophylactic pastes, dental flosses and the like permits n 2+ ions to exert its effect because the storage stability is high enough to maintain the increased concentration of active dissolved stannous ions in the composition for a prolonged period of time and can render the tooth enamel more resistant to acid attack when applied to teeth.
Inventors
- 👤 Syozi Nakashima
- 👤 Tosiyuki Ozawa
- 👤 Takeshi Naganuma
- 👤 Takashi Ujiie
- 👤 Satoshi Hayashi
- 👤 Yoshihito Ochiai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:13
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/20; A61K8/21; A61K8/24; A61K8/30; A61K8/55; A61Q; A61Q11/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
161 words
An oral composition for caries prophylaxis, comprising: a highly soluble stannous compound selected from the group consisting of stannous fluoride, stannous chloride, stannous chloride fluoride, sodium stannous fluoride, potassium stannous fluoride, stannous acetate, stannous hexafluorozirconate, stannous sulfate, stannous tartrate, stannous gluconate and mixtures thereof, said highly soluble stannous compound being present in the range of 0.03% to 5% by weight of the composition as stannous tin; a difficulty soluble stannous compound selected from the group consisting of stannous pyrophosphate, stannous metaphosphate, stannous oxide, stannous oxalate, stannous phosphate and mixtures thereof, said difficulty soluble stannous compound being present in the range of 0.05% to 10% by weight of the composition as stannous tin; and 0.1% to 20% by weight of the composition of a phytic acid compound selected from the group consisting of phytic acid, sodium phytate, potassium phytate, lithium phytate, ammonium phytate, magnesium phytate, zinc phytate, calcium phytate, aluminum phytate, phytin, double salts thereof and mixtures thereof, said composition being acidic.
Claim 2
Dependent Claim
161 words
An oral composition for caries prophylaxis, comprising: a highly soluble stannous compound selected from the group consisting of stannous fluoride, stannous chloride, stannous chloride fluoride, sodium stannous fluoride, potassium stannous fluoride, stannous acetate, stannous hexafluorozirconate, stannous sulfate, stannous tartrate, stannous gluconate and mixtures thereof, said highly soluble stannous compound being present in the range of 0.03% to 5% by weight of the composition as stannous tin; a difficulty soluble stannous compound selected from the group consisting of stannous pyrophosphate, stannous metaphosphate, stannous oxide, stannous oxalate, stannous phosphate and mixtures thereof, said difficulty soluble stannous compound being present in the range of 0.05% to 10% by weight of the composition as stannous tin; and 0.1% to 20% by weight of the composition of a phytic acid compound selected from the group consisting of phytic acid, sodium phytate, potassium phytate, lithium phytate, ammonium phytate, magnesium phytate, zinc phytate, calcium phytate, aluminum phytate, phytin, double salts thereof and mixtures thereof, said composition being acidic.
Claim 3
Dependent Claim
21 words
The oral composition according to claim 1, wherein a portion of the difficulty soluble stannous compound is in a precipitate form.
Claim 4
Dependent Claim
49 words
The oral composition according to claim 1, wherein the highly soluble stannous compound is stannous fluoride in an amount of 0.08 to 3% by weight of the composition, and the difficultly soluble stannous compound is stannous pyrophosphate in an amount of 0.1 to 3% by weight of the composition.
Claim 5
Dependent Claim
26 words
The oral composition according to claim 1, wherein the phytic acid compound is present in an amount of 0.5 to 5% by weight of the composition.
Claim 6
Dependent Claim
39 words
The oral composition according to claim 1, wherein said phytic acid compound is selected from the group consisting of phytic acid, sodium phytate, potassium phytate, lithium phytate, ammonium phytate, magnesium phytate, calcium phytate, double salts thereof and mixtures thereof.
Claim 7
Dependent Claim
15 words
The oral composition according to claim 1 or 2 in the form of a toothpaste.
Claim 8
Dependent Claim
16 words
The oral composition according to claim 1 or 2, in the form of a liquid mouthwash.
Claim 9
Dependent Claim
16 words
The oral composition according to claim 1 or 2, in the form of a mouthwash tablet.
Claim 10
Dependent Claim
16 words
The oral composition according to claim 1 or 2, in the form of a disintegratable tablet.
Claim 11
Dependent Claim
15 words
The oral composition according to claim 1 or 2, in the form of oral bands.
Claim 12
Dependent Claim
15 words
The oral composition according to claim 1 or 2, in the form of topical solutions.
Claim 13
Dependent Claim
16 words
The oral composition according to claim 1 or 2, in the form of a topical paste.
Claim 14
Dependent Claim
63 words
The oral composition according to claim 1 or 2, wherein a fluorine compound selected from the group consisting of sodium fluoride, potassium fluoride, lithium fluoride, ammonium fluoride, sodium monofluorophosphate, sodium hydrogen monofluorophosphate, potassium monofluorophosphate, ammonium monofluorophosphate, potassium hexafluorotitanate, potassium hexafluorozirconate and mixtures thereof is present in the composition in an amount capable of supplying 50 to 10,000 parts per million of fluorine ions.
Claim 15
Dependent Claim
29 words
The oral composition according to claim 13, wherein said fluorine compound is present in the composition in an amount capable of supplying 20-10,000 parts per million of fluorine ion.
Claim 16
Dependent Claim
19 words
The oral composition according to claim 1 or 2, wherein the composition has a pH of 2 to 7.
Claim 17
Dependent Claim
14 words
The oral composition according to claim 15, wherein the pH is 3 to 6.
References Cited (Backward Citations)
GB804486A
Cited
GB845611A
Cited
US2946725A
Cited
US3105798A
Cited
US3282792A
Cited
GB1160640A
Cited
US3549677A
Cited
GB1222197A
Cited
US3544678A
Cited
GB1384375A
Cited
GB1408922A
Cited
US3934002A
Cited
US4259316A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-14 | 1985-12-14 | 1986-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-14 | 1989-12-14 | 1990-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-14 | 1993-12-14 | 1994-06-15 | $7700.00 | Window Closed / Lapsed |