US5290766A
Expired / Lapsed
US
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Cardioplegic compositions
Assignee: National Heart Foundation of New Zealand
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Filing: 1992-02-18
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Granted: 1994-03-01
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Expires: 2012-02-18
Abstract
Abstract An aqueous cardioplegic solution providing significantly improved cardiac function after a period of exposure to cardioplegia, contains NaCl in the range of 70-110 mM; KCl in the range of 10-16 mM; CaCl2 in the range of 0.5-1.0 mM; MgCl2 in the range of 8-16 mM; NaHCO3 in the range of 10-20 mM; D-Glucose in the range of 5-15 mM; L-Aspartic acid in the range of 5-20 mM; and Lactobionic acid in the range of 0-15 mM.
Inventors
- 👤 Yee S. Choong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 02:24
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/14
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
68 words
A sterile aqueous cardioplegic solution comprising NaCl in the range of 70-110 mM; KCl in the range of 10-16 mM; CaCl 2 in the range of 0.5-1.0 mM; MgCl 2 in the range of 8-16 mM; NaHCO 3 in the range of 10-20 mM; D-Glucose in the range of 5-15 mM; L-Aspartic acid in the range of 5-20 mM; and Lactobionic acid in the range of 0-15 mM.
Claim 2
Dependent Claim
68 words
A sterile aqueous cardioplegic solution comprising NaCl in the range of 70-110 mM; KCl in the range of 10-16 mM; CaCl 2 in the range of 0.5-1.0 mM; MgCl 2 in the range of 8-16 mM; NaHCO 3 in the range of 10-20 mM; D-Glucose in the range of 5-15 mM; L-Aspartic acid in the range of 5-20 mM; and Lactobionic acid in the range of 0-15 mM.
Claim 3
Dependent Claim
65 words
A cardioplegic solution as claimed in claim 1, having a pH of about 7.5 and containing about 100 mM of NaCl; about 10 mM of KCl; about 0.8 mM of CaCl 2 ; about 10 mM of MgCl 2 ; about 10 mM of NaHCO 3 ; about 10 mM of D-Glucose; about 10 mM of L-Aspartic Acid; and about 5 mM of Lactobionic Acid.
Claim 4
Independent Claim
143 words
A method for creating a cardioplegic solution, in which the constituents are prepared and mixed as follows: (a) the required amounts of aspartic and lactobionic acids are each dissolved in a small amount of distilled water and neutralized to pH 7.5; (b) the cardioplegic solution is made by adding the various constituents in the sequence as listed here (1) NaCl, (2) KCl, (3) CaCl 2 , (4) MgCl 2 , (5) NaHCO 3 , (6) D-Glucose, (7) L-Aspartic acid, and (8) Lactobionic acid to a large volume (about 70% total) of distilled water, mixing the solution after each addition; (c) the balance of distilled water is added to the cardioplegic solution; (d) the cardioplegic solution is bubbled with a gaseous mixture of 95% oxygen:5% carbon dioxide for about 5 minutes; and (e) the cardioplegic solution is passed through a cardioplegic filter before use.
Claim 5
Independent Claim
143 words
A method for creating a cardioplegic solution, in which the constituents are prepared and mixed as follows: (a) the required amounts of aspartic and lactobionic acids are each dissolved in a small amount of distilled water and neutralized to pH 7.5; (b) the cardioplegic solution is made by adding the various constituents in the sequence as listed here (1) NaCl, (2) KCl, (3) CaCl 2 , (4) MgCl 2 , (5) NaHCO 3 , (6) D-Glucose, (7) L-Aspartic acid, and (8) Lactobionic acid to a large volume (about 70% total) of distilled water, mixing the solution after each addition; (c) the balance of distilled water is added to the cardioplegic solution; (d) the cardioplegic solution is bubbled with a gaseous mixture of 95% oxygen:5% carbon dioxide for about 5 minutes; and (e) the cardioplegic solution is passed through a cardioplegic filter before use.
References Cited (Backward Citations)
US3928574A
Cited
DE2425264A1
Cited
EP0012272A1
Cited
DE3026368A1
Cited
US4415556A
Cited
WO1982003773A1
Cited
US4605644A
Cited
US4719201A
Cited
US4988515A
Cited
US4923442A
Cited
US4938961A
Cited
US5082831A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-02-28 | 1997-08-30 | 1998-03-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-02-28 | 2001-08-30 | 2002-03-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-02-28 | 2005-08-30 | 2006-03-01 | $7700.00 | Window Closed / Lapsed |