US4719201A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for stimulating recovery from ischemia
Assignee: University of Minnesota System
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Filing: 1986-02-06
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Granted: 1988-01-12
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Expires: 2006-02-06
Abstract
Abstract The perfusion of ischemic tissue with dilute physiological salt solutions containing ribose reduces the period required for tissue function recovery and for the restoration of tissue ATP levels.
Inventors
- 👤 John E. Foker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 09:11
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
72 words
A method for reducing the recovery time of tissue function following ischemic insult comprising: (a) perfusing said tissue with an adenine-free solution incorporating ribose for about 24 hours in an amount effective to restore the tissue ATP level and tissue function to levels substantially equal to those present in the preischemic tissue; and (b) continuing said perfusion until the tissue maintains its restored function and ATP level when the perfusion is discontinued.
Claim 2
Independent Claim
72 words
A method for reducing the recovery time of tissue function following ischemic insult comprising: (a) perfusing said tissue with an adenine-free solution incorporating ribose for about 24 hours in an amount effective to restore the tissue ATP level and tissue function to levels substantially equal to those present in the preischemic tissue; and (b) continuing said perfusion until the tissue maintains its restored function and ATP level when the perfusion is discontinued.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said tissue is myocardial tissue.
Claim 4
Dependent Claim
15 words
The method of claim 2 wherein said ischemic insult is due to a myocardial infarction.
Claim 5
Dependent Claim
14 words
The method of claim 3 wherein said ischemic insult is produced during heart surgery.
Claim 6
Dependent Claim
22 words
The method of claim 3 wherein the ribose solution is infused directly into a chamber of the heart or is infused intraveneously.
Claim 7
Dependent Claim
16 words
The method of claim 2 wherein a solution of ribose in an intravenous solution is perfused.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-01-11 | 1991-07-13 | 1992-01-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-01-11 | 1995-07-13 | 1996-01-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-01-11 | 1999-07-13 | 2000-01-12 | $7700.00 | Window Closed / Lapsed |