Patent US5284624A successfully refreshed from Google Patents.
US5284624A
Expired / Lapsed
US
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Method of, and apparatus for, testing and measuring blood clotting time
Assignee: Individual
•
Filing: 1992-08-31
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Granted: 1994-02-08
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Expires: 2012-08-31
Abstract
Abstract The apparatus serves for testing and measuring blood clotting time. Blood or blood plasma (12) and a reagent (13) are introduced into a measuring cuvette (8). The clotting time is measured electro-optically with the aid of a stirring element (9) which is arranged in the measuring cuvette (8), can be attracted magnetically and is driven by a magnetic stirring device arranged outside the measuring cuvette (8). The method and apparatus are suitable for automatic measuring methods owing to the fact that blood plasma (12) and reagent (13) are introduced beside one another onto an essentially horizontal internal surface (10) of a measuring cuvette (8) provided with an opening above this surface (10), in that the measuring cuvette (8) and its contents are heated to the reaction temperature, in that the measuring cuvette is pivoted by essentially 90° in such a way that the internal surface (10) stands essentially perpendicular and plasma (12) and reagent (13) flow together, and in that the measurement is subsequently carried out.
Inventors
- 👤 Holger Behnk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 10:00
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4905
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
185 words
Measuring cuvette into which blood or blood plasma and a reagent are introduced for testing and measuring blood clotting time, comprising a bottom wall having a flat, substantially horizontal, elongated internal surface having a cross sectional area comprising a first portion and a second portion for accepting liquid plasma and liquid reagent, a pair of opposite, generally parallel elongated side walls, opposite first and second end walls including first and second internal end surfaces each having a substantially smaller cross sectional area than the elongated internal surface, an upper wall connected to the second end wall and the elongated side walls, the upper wall having an opening formed therein for receiving plasma on said first portion of said elongated internal surface and reagent on said second portion of said elongated internal surface, means formed on the elongated internal surface for preventing the plasma on the first portion and the reagent on the second portion from flowing together until the cuvette is pivoted, and a magnetically attracted stirring element disposed in the cuvette for promoting mixing of the plasma and reagent when the cuvette is pivoted.
Claim 2
Dependent Claim
185 words
Measuring cuvette into which blood or blood plasma and a reagent are introduced for testing and measuring blood clotting time, comprising a bottom wall having a flat, substantially horizontal, elongated internal surface having a cross sectional area comprising a first portion and a second portion for accepting liquid plasma and liquid reagent, a pair of opposite, generally parallel elongated side walls, opposite first and second end walls including first and second internal end surfaces each having a substantially smaller cross sectional area than the elongated internal surface, an upper wall connected to the second end wall and the elongated side walls, the upper wall having an opening formed therein for receiving plasma on said first portion of said elongated internal surface and reagent on said second portion of said elongated internal surface, means formed on the elongated internal surface for preventing the plasma on the first portion and the reagent on the second portion from flowing together until the cuvette is pivoted, and a magnetically attracted stirring element disposed in the cuvette for promoting mixing of the plasma and reagent when the cuvette is pivoted.
Claim 3
Dependent Claim
41 words
Measuring cuvette according to claim 1, wherein said means for preventing the plasma on said first portion and reagent on said second portion from flowing together comprises at least one of indentations and trough-shaped regions formed on the elongated internal surface.
Claim 4
Dependent Claim
48 words
Measuring cuvette according to claim 1, wherein said means for preventing the plasma and reagent from flowing together includes linearly-extending projections or notches formed on the elongated internal surface which define an interface which separates the internal surface into at least said first portion and said second portion.
Claim 5
Dependent Claim
32 words
Measuring cuvette according to claim 1, wherein said means for preventing the plasma and reagent from flowing together comprises linearly-extending projections which project inward into the cuvette from the elongated internal surface.
Claim 6
Dependent Claim
27 words
Measuring cuvette according to claim 1, wherein said means for preventing the plasma and reagent from flowing together comprises linearly-extended notches formed on the elongated internal surface.
Claim 7
Dependent Claim
35 words
Measuring cuvette according to claim 1, wherein the first internal end surface comprises two sloping faces which are connected at an obtuse angle, forming an indentation in the middle of the first internal end surface.
Claim 8
Dependent Claim
28 words
Measuring cuvette according to claim 6, wherein the second internal end surface is generally perpendicular to the elongated internal surface and has a central, cylindrical or oval indentation.
Claim 9
Dependent Claim
49 words
Measuring cuvette according to claim 7, wherein the stirring element is a mixing ball with a diameter, and the second end face has rim regions arranged around the indentation which are bevelled inwards, the rim regions having at least partially a smaller thickness than the diameter of the ball.
Claim 10
Dependent Claim
33 words
Measuring cuvette according to claim 6, wherein the stirring element is a mixing ball and the mixing ball is positioned proximate the first internal end surface before the plasma and reagent flow together.
Claim 11
Dependent Claim
33 words
Measuring cuvette according to claim 6, wherein the stirring element is a mixing ball and the mixing ball is positioned proximate the second internal end surface before the plasma and reagent flow together.
Claim 12
Dependent Claim
34 words
Measuring cuvette according to claim 6, wherein the second internal end surface includes an indentation formed by a pair of sloping inner wall surfaces that are connected to each other at an obtuse angle.
Claim 13
Independent Claim
193 words
An apparatus for measuring blood clotting time, the apparatus including a plurality of measuring cuvettes arranged in a holder, at least one of the cuvettes including a bottom wall having a flat, substantially horizontal, elongated internal surface for accepting liquid plasma and liquid reagent, the elongated internal surface having a cross sectional area comprising a first portion and a second portion, a pair of opposite, generally parallel elongated side walls, opposite first and second end walls including first and second internal end surfaces each having a substantially smaller cross sectional area than the elongated internal surface, an upper wall connected to the second end wall and the elongated side walls, the upper wall having an opening formed therein for receiving plasma onto said first portion of said elongated internal surface and reagent onto said second portion of said elongated internal surface, means formed on the elongated internal surface for preventing the plasma on the first portion and reagent on the second portion from flowing together until the cuvette is pivoted, and a magnetically attracted stirring element disposed in the cuvette for promoting mixing of the plasma and reagent when the cuvette is pivoted.
Claim 14
Independent Claim
193 words
An apparatus for measuring blood clotting time, the apparatus including a plurality of measuring cuvettes arranged in a holder, at least one of the cuvettes including a bottom wall having a flat, substantially horizontal, elongated internal surface for accepting liquid plasma and liquid reagent, the elongated internal surface having a cross sectional area comprising a first portion and a second portion, a pair of opposite, generally parallel elongated side walls, opposite first and second end walls including first and second internal end surfaces each having a substantially smaller cross sectional area than the elongated internal surface, an upper wall connected to the second end wall and the elongated side walls, the upper wall having an opening formed therein for receiving plasma onto said first portion of said elongated internal surface and reagent onto said second portion of said elongated internal surface, means formed on the elongated internal surface for preventing the plasma on the first portion and reagent on the second portion from flowing together until the cuvette is pivoted, and a magnetically attracted stirring element disposed in the cuvette for promoting mixing of the plasma and reagent when the cuvette is pivoted.
Claim 15
Dependent Claim
13 words
An apparatus according to claim 12, wherein the holder includes a toothed rack.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-02-07 | 1997-08-09 | 1998-02-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-02-07 | 2001-08-09 | 2002-02-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-02-07 | 2005-08-09 | 2006-02-08 | $7700.00 | Window Closed / Lapsed |