Patent US5281196A successfully refreshed from Google Patents.
US5281196A
Expired / Lapsed
US
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Skin treatment composition and method of use
Assignee: Individual
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Filing: 1992-05-22
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Granted: 1994-01-25
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Expires: 2012-05-22
Abstract
Abstract A composition and method of applying a composition of (a) between about 10 and 15 percent vitamin C, plus or minus 10 percent, by weight to volume, (b) a viscosity agent, and (c) water as the remainder of the composition to healthy surface tissue overlying unhealthy tissue to be treated by radiation therapy for thereby abating dermatitis, mucositis, and esophagitis normally attendant with radiation therapy, the method comprising the steps of identifying the healthy surface tissue in the path of a radiation beam proposed to treat the unhealthy tissue, the identified healthy tissue being pretreated with vitamin C to increase the concentration of ascorbic acid in the identified healthy tissue; applying the composition to the identified healthy tissue; waiting a period of time of about at least one hour prior to radiation therapy so as to allow the vitamin C of the composition to increase the concentration of ascorbic acid in the healthy tissue whereby free radicals from ensuing radiation therapy are scavenged by the increased concentration of ascorbic acid in the healthy tissue; applying therapeutic radiation to the pretreated healthy tissue and the unhealthy tissue in a predetermined target dosage so that unhealthy tissue will be destroyed but so that the increased concentration of ascorbic acid in the healthy tissue will scavenge free radicals from the applied radiation; and scavenging free radicals from the applied radiation by the increased concentration of ascorbic acid in the healthy tissue so that dermatitis, mucositis, and esophagitis normally resulting from radiation therapy are abated.
Inventors
- 👤 Thomas J. Sultenfuss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 15:50
CPC Classifications
A; A61; A61K; A61K41/00; A61K31/00; A61K31/33; A61K31/335; A61K31/365; A61K31/375; A61K2121/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
152 words
A method of applying a composition containing vitamin C to healthy surface tissue located in the path of a therapeutic radiation beam, wherein the undesired side effects of radiation therapy are abated, the method comprising the steps of: identifying the healthy surface tissue in the path of a radiation beam proposed to treat unhealthy tissue; applying the composition containing the vitamin C to the identified healthy tissue; waiting a period of time sufficient to allow the vitamin C of the composition to increase the concentration of ascorbic acid in the healthy tissue; again applying the composition containing the vitamin C to the identified healthy tissue; again waiting a period of time sufficient to allow the vitamin C of the composition to further increase the concentration of ascorbic acid in the healthy tissue; and exposing the unhealthy tissue and healthy tissue to radiation therapy subsequent to at least one of the waiting steps.
Claim 2
Independent Claim
152 words
A method of applying a composition containing vitamin C to healthy surface tissue located in the path of a therapeutic radiation beam, wherein the undesired side effects of radiation therapy are abated, the method comprising the steps of: identifying the healthy surface tissue in the path of a radiation beam proposed to treat unhealthy tissue; applying the composition containing the vitamin C to the identified healthy tissue; waiting a period of time sufficient to allow the vitamin C of the composition to increase the concentration of ascorbic acid in the healthy tissue; again applying the composition containing the vitamin C to the identified healthy tissue; again waiting a period of time sufficient to allow the vitamin C of the composition to further increase the concentration of ascorbic acid in the healthy tissue; and exposing the unhealthy tissue and healthy tissue to radiation therapy subsequent to at least one of the waiting steps.
Claim 3
Dependent Claim
38 words
The method as set forth in claim 1 wherein the composition comprises, in combination: between about 10 and 15 percent vitamin C within the limits of solubility; a viscosity agent; and water as the remainder of the composition.
Claim 4
Dependent Claim
45 words
The method as set forth in claim 2 wherein the vitamin C is ascorbic acid and the viscosity agent is propylene glycol constituting between about 15 and 20 percent of the composition, the composition being adapted to be applied topically for abating dermatitis and mucositis.
Claim 5
Dependent Claim
47 words
The method as set forth in claim 2 wherein the vitamin C is a salt of ascorbic acid and the viscosity agent is carboxy methyl cellulose constituting between about 1 and 2 percent of the composition, the composition being adapted to be applied internally for abating esophagitis.
Claim 6
Dependent Claim
20 words
The method as set forth in claim 1 wherein the composition is applied to the healthy tissue after radiation therapy.
Claim 7
Independent Claim
102 words
A method of treating unhealthy tissue, adjacent to healthy surface tissue, by radiation therapy, comprising the steps of: identifying the healthy surface tissue in the path of a radiation beam proposed to treat the unhealthy tissue, the identified healthy tissue being pretreated by applying a composition containing vitamin C to increase the concentration of ascorbic acid in the identified healthy tissue; and applying therapeutic radiation to the pretreated healthy tissue and the unhealthy tissue in a predetermined target dosage so that the unhealthy tissue will be destroyed but so that dermatitis, mucositis, and esophagitis normally attendant with radiation therapy will be abated.
Claim 8
Independent Claim
102 words
A method of treating unhealthy tissue, adjacent to healthy surface tissue, by radiation therapy, comprising the steps of: identifying the healthy surface tissue in the path of a radiation beam proposed to treat the unhealthy tissue, the identified healthy tissue being pretreated by applying a composition containing vitamin C to increase the concentration of ascorbic acid in the identified healthy tissue; and applying therapeutic radiation to the pretreated healthy tissue and the unhealthy tissue in a predetermined target dosage so that the unhealthy tissue will be destroyed but so that dermatitis, mucositis, and esophagitis normally attendant with radiation therapy will be abated.
Claim 9
Independent Claim
132 words
A method of delivering radiation therapy, comprising the steps of: identifying the healthy surface tissue in the path of a radiation beam to be treated, the identified healthy tissue being pretreated by applying a composition containing vitamin C, a viscosity agent, and water as the remainder of the composition to increase the concentration of ascorbic acid in the identified healthy tissue; again applying the composition containing the vitamin C to the identified healthy tissue; and applying therapeutic radiation to the pretreated healthy tissue and the unhealthy tissue in a predetermined target dosage so that the unhealthy tissue will be destroyed; and scavenging free radicals from the applied radiation by the increased concentration of ascorbic acid in the healthy tissue so that dermatitis, mucositis, and esophagitis normally resulting from radiation therapy are abated.
Claim 10
Independent Claim
132 words
A method of delivering radiation therapy, comprising the steps of: identifying the healthy surface tissue in the path of a radiation beam to be treated, the identified healthy tissue being pretreated by applying a composition containing vitamin C, a viscosity agent, and water as the remainder of the composition to increase the concentration of ascorbic acid in the identified healthy tissue; again applying the composition containing the vitamin C to the identified healthy tissue; and applying therapeutic radiation to the pretreated healthy tissue and the unhealthy tissue in a predetermined target dosage so that the unhealthy tissue will be destroyed; and scavenging free radicals from the applied radiation by the increased concentration of ascorbic acid in the healthy tissue so that dermatitis, mucositis, and esophagitis normally resulting from radiation therapy are abated.
Claim 11
Dependent Claim
37 words
The method as set forth in claim 7 wherein the composition comprises, in combination: between about 10 and 15 percent vitamin C by weight to volume; a viscosity agent; and water as the remainder of the composition.
Claim 12
Dependent Claim
45 words
The method as set forth in claim 8 wherein the vitamin C is ascorbic acid and the viscosity agent is propylene glycol constituting between about 15 and 20 percent of the composition, the composition being adapted to be applied topically for abating dermatitis and mucositis.
Claim 13
Dependent Claim
46 words
The method as set forth in claim 8 wherein the vitamin C is a salt ascorbic acid and the viscosity agent is carboxy methyl cellulose constituting between about 1 and 2 percent of the composition, the composition being adapted to be applied internally for abating esophagitis.
Claim 14
Independent Claim
245 words
A method of applying a composition of (a) between about 10 and 15 percent vitamin C by weight to volume, (b) a viscosity agent, and (c) water as the remainder of the composition to healthy surface tissue overlying unhealthy tissue to be treated by radiation therapy for thereby abating dermatitis, mucositis, and esophagitis normally attendant with radiation therapy, the method comprising the steps of: identifying the healthy surface tissue in the path of a radiation beam proposed to treat the unhealthy tissue, the identified healthy tissue being pretreated with vitamin C to increase the concentration of ascorbic acid in the identified healthy tissue; applying the composition to the identified healthy tissue; waiting a period of time of about at least one hour prior to radiation therapy so as to allow the vitamin C of the composition to increase the concentration of ascorbic acid in the healthy tissue whereby free radicals from ensuing radiation therapy are scavenged by the increased concentration of ascorbic acid in the healthy tissue; applying therapeutic radiation to the pretreated healthy tissue and the unhealthy tissue in a predetermined target dosage so that the unhealthy tissue will be destroyed but so that the increased concentration of ascorbic acid in the healthy tissue will scavenge free radicals from the applied radiation; and scavenging free radicals from the applied radiation by the increased concentration of ascorbic acid in the healthy tissue so that dermatitis, mucositis, and esophagitis normally resulting from radiation therapy are abated.
Claim 15
Independent Claim
245 words
A method of applying a composition of (a) between about 10 and 15 percent vitamin C by weight to volume, (b) a viscosity agent, and (c) water as the remainder of the composition to healthy surface tissue overlying unhealthy tissue to be treated by radiation therapy for thereby abating dermatitis, mucositis, and esophagitis normally attendant with radiation therapy, the method comprising the steps of: identifying the healthy surface tissue in the path of a radiation beam proposed to treat the unhealthy tissue, the identified healthy tissue being pretreated with vitamin C to increase the concentration of ascorbic acid in the identified healthy tissue; applying the composition to the identified healthy tissue; waiting a period of time of about at least one hour prior to radiation therapy so as to allow the vitamin C of the composition to increase the concentration of ascorbic acid in the healthy tissue whereby free radicals from ensuing radiation therapy are scavenged by the increased concentration of ascorbic acid in the healthy tissue; applying therapeutic radiation to the pretreated healthy tissue and the unhealthy tissue in a predetermined target dosage so that the unhealthy tissue will be destroyed but so that the increased concentration of ascorbic acid in the healthy tissue will scavenge free radicals from the applied radiation; and scavenging free radicals from the applied radiation by the increased concentration of ascorbic acid in the healthy tissue so that dermatitis, mucositis, and esophagitis normally resulting from radiation therapy are abated.
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