Cosmetic pharmaceutical or foodstuff composition comprising an aqueous dispersion of lipidic vesicles

Claim 2

A composition comprising, in an aqueous medium, a dispersion of lipid vesicles encapsulating an aqueous phase, said lipid vesicles having a lamellar structure comprising at least two lipidic concentrically arranged layers defining an enclosed volume so as to encapsulate said aqueous phase, and lipidic phase forming said layers comprising at least one compound having the formula ##STR9## wherein R represents a linear, saturated or unsaturated hydrocarbon chain containing 9 to 17 carbon atoms.

Claim 3

The composition of claim 1 wherein said lipidic phase is present in an amount ranging from 0.5 to 25 percent by weight based on the total weight of said composition.

Claim 4

The composition of claim 1 wherein the acyl R--CO-residue is selected from the group consisting of a decanoyl, dodecanoyl, myristoyl, hexadecanoyl, stearoyl, oleoyl, linoleoyl and linolenoyl residue.

Claim 5

The composition of claim 1 wherein said compound of formula I is selected from the group consisting of O-oleoyl-6-D-glucose, O-decanoyl-6-D-glucose, O-dodecanoyl-6-D-glucose and O-hexadecanoyl-6-D-glucose.

Claim 6

The composition of claim 1 wherein said lipidic phase forming said layers also includes an ionic amphiphilic lipid selected from the group consisting of a natural phospholipid, a synthetic phospholipid, an amphoteric compound and an anionic compound.

Claim 7

The composition of claim 1 wherein said lipidic phase forming said layers also includes another non-ionic amphiphilic lipid selected from the group consisting of (1) a linear or branched chain polyglycerol ether having the formula ##STR10## wherein --C 3 H 5 (OH)O, jointly or separately represents --CH 2 CHOHCH 2 O--, ##STR11## n has a statistical average value ranging from 1 to 6, R 0 represents (a) an aliphatic, linear or branched, saturated or unsaturated chain containing 12 to 30 carbon atoms or a lanolin alcohol hydrocarbon chain, or the residue of a long chain diol, (b) R 1 CO wherein R 1 represents an aliphatic, linear or branched, radical having 11 to 17 carbon atoms, (c) ##STR12## wherein R 2 represents (a) or (b) defined above for R 0 and wherein OC 2 H 3 (R 3 ) represents ##STR13## wherein R 3 represents (a) defined above for R 0 , (2) a linear or branched polyglycerol ether having two fatty chains, (3) a fatty polyoxyethylenated alcohol, a fatty polyoxyethylenated sterol or a polyoxyethylenated phytosterol, (4) a polyol ether, (5) a polyol ester, (6) an oxyethylenated polyol ester, (7) a natural or synthetic glycolipid, and (8) a hydroxyamide having the formula ##STR14## wherein R 4 represents alkyl or alkenyl having 7 to 21 carbon atoms, R 5 represents a saturated or unsaturated hydrocarbon radical having 7 to 31 carbon atoms, COA represents a member selected from the group consisting of (i) ##STR15## wherein B is a radical derived from a mono- or polyhydroxylated primary or secondary amine, R 6 is hydrogen, methyl, ethyl or hydroxyethyl and (ii) --COOZ wherein Z represents a polyol residue having 3-7 carbon atoms.

Claim 8

The composition of claim 1 wherein said lipidic phase forming said layers also contains at least one additive selected from the group consisting of a fatty alcohol, a fatty diol, a sterol, a fatty amine or a quaternary ammonium derivative thereof, a hydroxyalkylamine, a dihydroxyalkylamine, a polyoxyethylenated fatty amine, a fatty amino-alcohol ester or a salt thereof or a quaternary ammonium derivative thereof, a fatty alcohol phosphoric ester, an alkyl sulphate, a polypeptide polymer, a protein polymer, and a lipoprotide selected from a mono- or polyacylated amino acid, or a polypeptide derivative having an R'-CO-aryl residue wherein R' is a hydrocarbon chain containing 13-19 carbon atoms, and wherein at least one of the functions linking the polypeptide chain or amino-acid residue with the lipophile chain being an amide function and wherein at least a portion of the polypeptide chain or amino-acid residue carboxylic functions is neutralized by an alkaline cation or an ammonium ion.

Claim 9

The composition of claim 1 wherein the aqueous phase encapsulated in said vehicles is an aqueous solution of an active substance.

Claim 10

The composition of claim 1 wherein said aqueous medium in which said vesicles are dispersed or said aqueous phase encapsulated in said vesicles, or both, contain at least one water-soluble cosmetic substance selected from the group consisting of a moisturizer, a suntan compound, a skin coloring agent, a solar protection agent, an antiperspirant agent, a deodorant, an astringent, a freshening product, a tonic product, a wound-healing product, a keratolytic product, a depilatory, a perfumed lotion, a water-soluble colorant, an antidandruff agent, an antiseborrheic agent, an oxidizer and a reducing agent.

Claim 11

The composition of claim 1 wherein said aqueous medium in which said vesicles are dispersed or said aqueous phase encapsulated in said vesicles, or both, contain at least one pharmaceutical substance selected from a vitamin, a hormone, an enzyme, a vaccine, an anti-inflammatory agent, an antibiotic or a bactericide.

Claim 12

The composition of claim 1 wherein said lipidic phase forming said layers also contains at least one liposoluble active substance.

Claim 13

The composition of claim 11 wherein said liposoluble active substance is selected from a solar filter, an agent for improving dry skin, vitamin E or F, vitamin A or an ester thereof, retinoic acid, an antioxidant, an essential fatty acid, glycyrrhetinic acid, a keratolytic agent or a carotenoid.

Claim 14

The composition of claim 1 wherein said aqueous medium containing said vesicles dispersed therein also contains a dispersion of a water-insoluble liquid present in an amount ranging from 2 to 70 percent by weight based on the total weight of said composition and wherein the weight ratio of said lipid vesicles to said water-insoluble liquid dispersed in said aqueous medium ranges from 0.02/1 to 10/1.

Claim 15

The composition of claim 13 wherein said water-insoluble liquid is selected from a fatty acid ester having the formula R 7 --COOR 8 wherein R 7 is a fatty acid residue containing 7 to 19 carbon atoms and R 8 is a branched hydrocarbon chain containing 3 to 20 carbon atoms; a hydrocarbon; paraffin oil; perhydrosqualene; perfluorodecahydro naphthalene; perfluoroributylamine; and a polysiloxane.

Claim 16

The composition of claim 13 wherein said water-insoluble liquid dispersed in said aqueous medium also contains a perfume or a liposoluble active substance, or both.

Claim 17

The composition of claim 1 wherein said aqueous medium in which said vesicles are dispersed also contains at least one additive selected from the group consisting of an opacifier, a gelling compound, an essence, a perfume, an anti-solar filter and a colorant.

Claim 18

The composition of claim 15 wherein said liposoluble active substance is selected from the group consisting of an anti-solar filter, a substance for improving the condition of dry skin and an antioxidant.

Claim 19

The composition of claim 13 wherein said lipidic phase forming said layers is an edible lipid, said aqueous phase encapsulated in said vesicles and said aqueous medium in which said vesicles are dispersed optionally contain at least one water-soluble vitamin, and said water-insoluble liquid dispersed in said aqueous medium contains an edible oil and optionally a liposoluble vitamin.