US5246708A
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Methods for promoting wound healing with deoxyribonucleosides
Assignee: Pro Neuron Inc
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Filing: 1992-07-13
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Granted: 1993-09-21
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Expires: 2012-07-13
Abstract
Abstract Methods are provided for promoting wound healing in animals by administering compositions containing two or more of the following 2'-deoxyribonucleosides: 2'-deoxyadenosine, 2'-deoxyguanosine, 2'-deoxy-cytidine, or thymidine. 3'- and 5'-phosphate derivatives of these 2'-deoxynucleosides are also effective in promoting wound healing.
Inventors
- 👤 Reid W. von Borstel
- 👤 Michael K. Bamat
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 18:49
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K45/00; A61K45/06; C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10
Claims Analysis
Total Claims: 48
Claim 1
Independent Claim
50 words
A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 2
Independent Claim
50 words
A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
21 words
A method as in claim 1 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
21 words
A method as in claim 1 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
21 words
A method as in claim 1 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.
Claim 6
Independent Claim
72 words
A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3'- or 5'-phosphate, or a 3'- or 5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 7
Independent Claim
72 words
A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3'- or 5'-phosphate, or a 3'- or 5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 8
Dependent Claim
30 words
A method as in claim 5 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
30 words
A method as in claim 5 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
30 words
A method as in claim 6 wherein said composition of matter further comprises (d) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
14 words
A method as in claim 1 or 5 further comprising a pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
15 words
A method as in claim 1 or 5 wherein said wound is a mucosal wound.
Claim 13
Dependent Claim
15 words
A method as in claim 1 or 5 wherein said wound is a dermal wound.
Claim 14
Dependent Claim
15 words
A method as in claim 1 or 5 wherein said wound is a surgical incision.
Claim 15
Dependent Claim
14 words
A method as in claim 1 or 5 wherein said wound is a burn.
Claim 16
Dependent Claim
14 words
A method as in claim 1 or 5 wherein said wound is an ulcer.
Claim 17
Dependent Claim
13 words
A method as in claim 14 wherein said ulcer is a dermal ulcer.
Claim 18
Dependent Claim
13 words
A method as in claim 14 wherein said ulcer is a mucosal ulcer.
Claim 19
Independent Claim
58 words
A method for promoting gastric or duodenal ulcer healing comprising administering to an animal possessing a gastric or duodenal ulcer a gastric or duodenal ulcer-healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 20
Independent Claim
58 words
A method for promoting gastric or duodenal ulcer healing comprising administering to an animal possessing a gastric or duodenal ulcer a gastric or duodenal ulcer-healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 21
Dependent Claim
21 words
A method as in claim 17 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof.
Claim 22
Dependent Claim
21 words
A method as in claim 17 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.
Claim 23
Dependent Claim
21 words
A method as in claim 18 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.
Claim 24
Independent Claim
79 words
A method for promoting gastric or duodenal ulcer healing comprising administering to an animal possessing a gastric or duodenal ulcer a gastric or duodenal ulcer-healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3', a 5' phosphate, or a 3',5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 25
Independent Claim
79 words
A method for promoting gastric or duodenal ulcer healing comprising administering to an animal possessing a gastric or duodenal ulcer a gastric or duodenal ulcer-healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3', a 5' phosphate, or a 3',5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 26
Dependent Claim
30 words
A method as in claim 21 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof.
Claim 27
Dependent Claim
30 words
A method as in claim 21 wherein said composition of matter further comprises (c) a 3'- or 5'-phosphate, or a 3',5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.
Claim 28
Dependent Claim
30 words
A method as in claim 22 wherein said composition of matter further comprises (d) a, 3',5' phosphate or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.
Claim 29
Independent Claim
56 words
A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof, in the form of a liposome.
Claim 30
Independent Claim
56 words
A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof, in the form of a liposome.
Claim 31
Dependent Claim
21 words
A method as in claim 25 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof.
Claim 32
Dependent Claim
21 words
A method as in claim 25 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.
Claim 33
Dependent Claim
21 words
A method as in claim 26 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.
Claim 34
Independent Claim
76 words
A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof, in the form of a liposome.
Claim 35
Independent Claim
76 words
A method for promoting wound healing comprising administering to an animal possessing a wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof, in the form of a liposome.
Claim 36
Dependent Claim
30 words
A method as in claim 29 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof.
Claim 37
Dependent Claim
30 words
A method as in claim 29 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.
Claim 38
Dependent Claim
30 words
A method as in claim 30 wherein said composition of matter further comprises (d) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.
Claim 39
Independent Claim
55 words
A method for promoting wound healing in an animal with corticosteroid-induced impaired wound healing comprising administering to the wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 40
Independent Claim
55 words
A method for promoting wound healing in an animal with corticosteroid-induced impaired wound healing comprising administering to the wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol 2'-deoxycytidine, and (b) from 90 to 10 percent by mol 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 41
Dependent Claim
21 words
A method as in claim 33 wherein said composition of matter further comprises (c) 2'-deoxyadenosine or a pharmaceutically acceptable salt thereof.
Claim 42
Dependent Claim
21 words
A method as in claim 33 wherein said composition of matter further comprises (c) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.
Claim 43
Dependent Claim
21 words
A method as in claim 34 wherein said composition of matter further comprises (d) 2'-deoxythymidine or a pharmaceutically acceptable salt thereof.
Claim 44
Independent Claim
75 words
A method for promoting wound healing in an animal with corticosteroid-induced impaired wound healing comprising administering to the wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 45
Independent Claim
75 words
A method for promoting wound healing in an animal with corticosteroid-induced impaired wound healing comprising administering to the wound a wound healing effective amount of a composition of matter comprising, (a) from 10 to 90 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxycytidine, and (b) from 90 to 10 percent by mol of a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyguanosine, or the pharmaceutically acceptable salts thereof.
Claim 46
Dependent Claim
30 words
A method as in claim 37 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxyadenosine, or a pharmaceutically acceptable salt thereof.
Claim 47
Dependent Claim
30 words
A method as in claim 37 wherein said composition of matter further comprises (c) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.
Claim 48
Dependent Claim
30 words
A method as in claim 38 wherein said composition of matter further comprises (d) a 3'-or 5'-phosphate, or a 3', 5'-diphosphate ester of 2'-deoxythymidine, or a pharmaceutically acceptable salt thereof.
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