US4758553A
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Compositions of nucletic acid components for nutritional replenishment
Assignee: Ajinomoto Co Inc
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Filing: 1987-09-30
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Granted: 1988-07-19
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Expires: 2007-09-30
Abstract
Abstract This invention provides a composition of nucleic acid components for nutritional replenishment characterized in that the composition comprises as effective components at least two nucleic acid compounds selected from the group consisting of (a) nucleic acid bases and pharmaceutically acceptable salts thereof, (b) nucleosides and pharmaceutically acceptable salts thereof and (c) nucleotides and pharmaceutically acceptable salts thereof.
Inventors
- 👤 Shohei Ogoshi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:31
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61P; A61P3/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
71 words
A composition of nucleic acid components for nutritional replenishment to a patient having impaired protein metabolism, comprising as effective components a combination of nucleic acid components or their pharmaceutically acceptable salts, said combination being selected from the group consisting of combinations (i) and (ii); (i) inosine-n'-monophosphate (IMP), guanosine-n'-monophosphate (GMP), cytidine-n'-monophosphate (CMP), uridine-n'-monophosphate (UMP) and thymidine, and (ii) inosine, cytidine, guanosine-n'-monophosphate (GMP), uridine and thymidine, wherein n' is 2', 3' or 5'.
Claim 2
Dependent Claim
71 words
A composition of nucleic acid components for nutritional replenishment to a patient having impaired protein metabolism, comprising as effective components a combination of nucleic acid components or their pharmaceutically acceptable salts, said combination being selected from the group consisting of combinations (i) and (ii); (i) inosine-n'-monophosphate (IMP), guanosine-n'-monophosphate (GMP), cytidine-n'-monophosphate (CMP), uridine-n'-monophosphate (UMP) and thymidine, and (ii) inosine, cytidine, guanosine-n'-monophosphate (GMP), uridine and thymidine, wherein n' is 2', 3' or 5'.
Claim 3
Dependent Claim
22 words
A composition as defined in claim 1 wherein the combination of nucleic acid components has the following mole ratio: IMP/GMP/CMP/UMP/thymidine=4:4:4:3:1 or 2:2:2:1:1.
Claim 4
Dependent Claim
20 words
A composition as defined in claim 1 wherein the combination of nucleic acid components has the following mole ration: inosine/cytidine/GMP/uridine/thymidine=4:4:4:3:1.
Claim 5
Dependent Claim
49 words
A composition as defined in claim 1, further comprising additives and an aqueous medium which are pharmaceutically suitable, said nucleic acid components and said additives being dissolved in the aqueous medium to form an aqueous solution, said solution being sterilized and being in the form of a parenteral solution.
Claim 6
Dependent Claim
19 words
A composition as defined in claim 1 which is in the form of a powdery mixture for enteral administration.
Claim 7
Dependent Claim
18 words
A composition as defined in claim 4 which is used in combination with an amino acid parenteral solution.
Claim 8
Dependent Claim
60 words
A composition as defined in claim 1, further comprising an aqueous medium, a sweetener, a stabilizer and a preservative which are pharmaceutically suitable, said nucleic acid components and said sweetener, stabilizer and preservative being dissolved in the aqueous medium to form an aqueous solution, said solution being sterilized and being in the form of a liquid composition for enteral administration.
Claim 9
Independent Claim
76 words
A method of nutritional replenishment which comprises administering to a patient with impaired protein metabolism an effective amount of a composition comprising as effective components a combination of nucleic acid components or their pharmaceutically acceptable salts, said combination being selected from the group consisting of combinations (i) and (ii); (i) inosine-n'-monophosphate (IMP), guanosine-n'-monophosphate (GMP), cytidine-n'-monophosphate (CMP), uridine-n'-monophosphate (UMP) and thymidine, and (ii) inosine, cytidine, guanosine-n'-monophosphate (GMP), uridine and thymidine, wherein n' is 2', 3' or 5'.
Claim 10
Independent Claim
76 words
A method of nutritional replenishment which comprises administering to a patient with impaired protein metabolism an effective amount of a composition comprising as effective components a combination of nucleic acid components or their pharmaceutically acceptable salts, said combination being selected from the group consisting of combinations (i) and (ii); (i) inosine-n'-monophosphate (IMP), guanosine-n'-monophosphate (GMP), cytidine-n'-monophosphate (CMP), uridine-n'-monophosphate (UMP) and thymidine, and (ii) inosine, cytidine, guanosine-n'-monophosphate (GMP), uridine and thymidine, wherein n' is 2', 3' or 5'.
Claim 11
Dependent Claim
55 words
A method of nutritional replenishment as defined in claim 8 wherein said composition further comprises additives and an aqueous medium which are pharmaceutically suitable, said nucleic acid components and said additives being dissolved in the aqueous medium to form an aqueous solution, said solution being sterilized and being in the form of a parenteral solution.
Claim 12
Dependent Claim
20 words
A method as defined in claim 9 wherein the composition is given in combination with an amino acid parenteral solution.
Claim 13
Dependent Claim
28 words
A method as defined in claim 8 wherein the composition is given at a daily dose of 1 to 50 g, calculated as the effective components, per adult.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-07-19 | 1992-01-18 | 1992-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-19 | 1996-01-18 | 1996-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-19 | 2000-01-18 | 2000-07-19 | $7700.00 | Window Closed / Lapsed |