Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses

Claim 1

A method for the treatment of diseases caused by DNA viruses or RNA viruses comprising administering to a host suffering from said diseases an effective amount of a compound of the formula I ##STR7## in which V is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, fluorine, chlorine, bromine, iodine or hydrogen, n is an integer from 1 to 5, W is a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a straight-chain or branched alkoxy group having 1 to 10 carbon atoms, an aryl group having 6, 10 or 14 carbon atoms, or is an alkyl group having 1 to 4 carbon atoms which is substituted by one or more substituents from the group consisting of a radical of the formula --COOR 6 , chlorine, bromine, iodine, fluorine, a fused-on aromatic and said fused-on aromatic which is substituted by an alkyl group having 1 to 4 carbon atoms, cyanide, nitro or hydrogen, or is a radical of the formula Ia --COOR.sup.6 Ia in which R 6 is a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium, hydrogen or a straight-chain or branched halogenoalkyl group having 1 to 20 carbon atoms, in which halogen is chlorine, bromine, iodine or fluorine, R 1 and R 2 , which can be identical or different, are a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium, hydrogen or a straight-chain or branched halogenoalkyl group having 1 to 20 carbon atoms, in which halogen is chlorine, bromine, iodine or fluorine, R 3 and R 4 , which are identical or different, are a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkynyl or alkenyl group having 2 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a straight-chain or branched alkoxy group having 1 to 10 carbon atoms, hydrogen, fluorine, chlorine, bromine or iodine, or are a radical of the formula Ib --COOR.sup.7 Ib in which R 7 is a straight-chain or branched alkyl group having 1 to 4 carbon atoms and X, Y and Z, which are identical or different, are oxygen or sulfur.

Claim 2

A method for the treatment of diseases caused by DNA viruses or RNA viruses comprising administering to a host suffering from said diseases an effective amount of a compound of the formula I ##STR7## in which V is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, fluorine, chlorine, bromine, iodine or hydrogen, n is an integer from 1 to 5, W is a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a straight-chain or branched alkoxy group having 1 to 10 carbon atoms, an aryl group having 6, 10 or 14 carbon atoms, or is an alkyl group having 1 to 4 carbon atoms which is substituted by one or more substituents from the group consisting of a radical of the formula --COOR 6 , chlorine, bromine, iodine, fluorine, a fused-on aromatic and said fused-on aromatic which is substituted by an alkyl group having 1 to 4 carbon atoms, cyanide, nitro or hydrogen, or is a radical of the formula Ia --COOR.sup.6 Ia in which R 6 is a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium, hydrogen or a straight-chain or branched halogenoalkyl group having 1 to 20 carbon atoms, in which halogen is chlorine, bromine, iodine or fluorine, R 1 and R 2 , which can be identical or different, are a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium, hydrogen or a straight-chain or branched halogenoalkyl group having 1 to 20 carbon atoms, in which halogen is chlorine, bromine, iodine or fluorine, R 3 and R 4 , which are identical or different, are a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkynyl or alkenyl group having 2 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a straight-chain or branched alkoxy group having 1 to 10 carbon atoms, hydrogen, fluorine, chlorine, bromine or iodine, or are a radical of the formula Ib --COOR.sup.7 Ib in which R 7 is a straight-chain or branched alkyl group having 1 to 4 carbon atoms and X, Y and Z, which are identical or different, are oxygen or sulfur.

Claim 4

A method for the treatment of diseases caused by DNA viruses or RNA viruses comprising administering to a host suffering from said diseases a pharmaceutical composition which comprises an effective amount of a compound of the formula I ##STR8## in which V is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, fluorine, chlorine, bromine, iodine or hydrogen, n is an integer from 1 to 5, W is a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a straight-chain or branched alkoxy group having 1 to 10 carbon atoms, an aryl group having 6, 10 or 14 carbon atoms, or is an alkyl group having 1 to 4 carbon atoms which is substituted by one or more substituents from the group consisting of a radical of the formula --COOR 6 , chlorine, bromine, iodine, fluorine, a fused-on aromatic and said fused-on aromatic which is substituted by an alkyl group having 1 to 4 carbon atoms, cyanide, nitro or hydrogen, or is a radical of the formula Ia --COOR.sup.6 Ia in which R 6 is a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium, hydrogen or a straight-chain or branched halogenoalkyl group having 1 to 20 carbon atoms, in which halogen is chlorine, bromine, iodine or fluorine, R 1 and R 2 , which can be identical or different, are a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium, hydrogen or a straight-chain or branched halogenoalkyl group having 1 to 20 carbon atoms, in which halogen is chlorine, bromine, iodine or fluorine, R 3 and R 4 , which are identical or different, are a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkynyl or alkenyl group having 2 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a straight-chain or branched alkoxy group having 1 to 10 carbon atoms, hydrogen, fluorine, chlorine, bromine or iodine, or are a radical of the formula Ib --COOR.sup.7 Ib in which R 7 is a straight-chain or branched alkyl group having 1 to 4 carbon atoms and X, Y and Z, which are identical or different, are oxygen or sulfur, together with a physiologically tolerated excipient.

Claim 5

A method for the treatment of diseases caused by DNA viruses or RNA viruses comprising administering to a host suffering from said diseases a pharmaceutical composition which comprises an effective amount of a compound of the formula I ##STR8## in which V is a straight-chain or branched alkyl group having 1 to 4 carbon atoms, fluorine, chlorine, bromine, iodine or hydrogen, n is an integer from 1 to 5, W is a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, a straight-chain or branched alkoxy group having 1 to 10 carbon atoms, an aryl group having 6, 10 or 14 carbon atoms, or is an alkyl group having 1 to 4 carbon atoms which is substituted by one or more substituents from the group consisting of a radical of the formula --COOR 6 , chlorine, bromine, iodine, fluorine, a fused-on aromatic and said fused-on aromatic which is substituted by an alkyl group having 1 to 4 carbon atoms, cyanide, nitro or hydrogen, or is a radical of the formula Ia --COOR.sup.6 Ia in which R 6 is a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium, hydrogen or a straight-chain or branched halogenoalkyl group having 1 to 20 carbon atoms, in which halogen is chlorine, bromine, iodine or fluorine, R 1 and R 2 , which can be identical or different, are a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkenyl or alkynyl group having 2 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium, hydrogen or a straight-chain or branched halogenoalkyl group having 1 to 20 carbon atoms, in which halogen is chlorine, bromine, iodine or fluorine, R 3 and R 4 , which are identical or different, are a straight-chain or branched alkyl group having 1 to 20 carbon atoms, a straight-chain or branched alkynyl or alkenyl group having 2 to 20 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an aralkyl group having 7 to 20 carbon atoms, a straight-chain or branched alkoxy group having 1 to 10 carbon atoms, hydrogen, fluorine, chlorine, bromine or iodine, or are a radical of the formula Ib --COOR.sup.7 Ib in which R 7 is a straight-chain or branched alkyl group having 1 to 4 carbon atoms and X, Y and Z, which are identical or different, are oxygen or sulfur, together with a physiologically tolerated excipient.