Patent US5242902A successfully refreshed from Google Patents.
US5242902A
Expired / Lapsed
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Defensin peptide compositions and methods for their use
Assignee: University of California
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Filing: 1989-09-06
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Granted: 1993-09-07
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Expires: 2009-09-06
Abstract
Abstract A method for treating cutaneous and corneal wounds as well as certain microbial-related diseases comprises topically applying a defensin peptide to the affected tissue. The compositions comprise a natural, synthetic, or analog defensin molecule having both a mitogenic activity capable of stimulating cell growth and an antimicrobial activity capable of inhibiting the growth of a wide variety of pathogens. In addition to therapeutic use, the defensins are useful as mitogens in cell and tissue culture media.
Inventors
- 👤 Christopher J. Murphy
- 👤 Ted W. Reid
- 👤 Mark J. Mannis
- 👤 Bradley A. Foster
- 👤 James S. Cullor
- 👤 Michael E. Selsted
- 👤 Robert I. Lehrer
- 👤 Tomas Ganz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:58
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4723; A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/1703; A61K38/1709; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/19
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
31 words
A method for treating wounds in mammalian tissue to promote healing, said method comprising applying a defensin peptide to the wound in an amount sufficient to promote healing of the wound.
Claim 2
Independent Claim
31 words
A method for treating wounds in mammalian tissue to promote healing, said method comprising applying a defensin peptide to the wound in an amount sufficient to promote healing of the wound.
Claim 3
Dependent Claim
17 words
A method as in claim 1, wherein the defensin peptide is applied to a corneal epithelial wound.
Claim 4
Dependent Claim
19 words
A method as in claim 2, wherein the defensin peptide is applied to a corneal epithelial or stromal wound.
Claim 5
Dependent Claim
29 words
A method as in claim 2, wherein the defensin peptide is present in a physiologically-acceptable carrier at a concentration in the range from about 1 nM to 10 mM.
Claim 6
Dependent Claim
31 words
A method as in claim 2, wherein the defensin peptide is selected from the group consisting of HNP-1, HNP-2, HNP-3, HNP-4, NP-1, NP-2, NP-3A, NP-3B, NP-4, RatNP-1, RatNP-2, RatNP-4, and GPNP.
Claim 7
Independent Claim
30 words
A method for treating corneal wounds and keratitis, said method comprising applying a defensin peptide to the eye of an affected host in an amount sufficient to effect said treating.
Claim 8
Independent Claim
30 words
A method for treating corneal wounds and keratitis, said method comprising applying a defensin peptide to the eye of an affected host in an amount sufficient to effect said treating.
Claim 9
Dependent Claim
17 words
A method as in claim 6, wherein the host suffers from a traumatic wound to the eye.
Claim 10
Dependent Claim
14 words
A method as in claim 6, wherein the wound is a corneal epithelial wound.
Claim 11
Dependent Claim
14 words
A method as in claim 6, wherein the wound extends to the stromal layer.
Claim 12
Dependent Claim
13 words
A method as in claim 6, wherein the host suffers from microbial keratitis.
Claim 13
Dependent Claim
23 words
A method as in claim 6, wherein the defensin peptide is applied at a concentration of from about 1 nM to 10 mM.
Claim 14
Dependent Claim
31 words
A method as in claim 6, wherein the defensin peptide is selected from the group consisting of HNP-1, HNP-2, HNP-3, HNP-4, NP-1, NP-2, NP-3A, NP-4, NP-5, RatNP-1, RatNP-2, RatNP-4, and GPNP.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-09-06 | 1997-03-08 | 1997-09-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-09-06 | 2001-03-08 | 2001-09-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-09-06 | 2005-03-08 | 2005-09-07 | $7700.00 | Window Closed / Lapsed |