US5032574A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel antimicrobial peptide
Assignee: Incyte Corp
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Filing: 1988-05-26
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Granted: 1991-07-16
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Expires: 2008-05-26
Abstract
Abstract This invention provides a purified polypeptide useful as an antimicrobial agent. This purified polypeptide has been derived from human granulocytes, and has a molecular weight of about 3,700 daltons and the N-terminal amino acid sequence val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr-glu- leu-arg-val-gly-asn-cys-leu-ile-gly-gly-val-ser-phe-thr-try-cys-thr-arg-val. This invention also provides methods for producing this polypeptide, pharmaceutical compositions containing the polypeptide, and uses thereof.
Inventors
- 👤 Craig G. Wilde
- 👤 Joseph E. Griffith
- 👤 Marian N. Marra
- 👤 Randal W. Scott
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:00
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4723; A; A61; A61P; A61P31/00; A61P31/04; A61K; A61K38/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
11 words
A purified polypeptide having the amino acid sequence NH 2 -val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr-glu-leu-arg-val-gly-asn-cys-leu-ile-gly-gly-val-ser-phe-thr-cys-cys-thr-arg-val.
Claim 2
Dependent Claim
11 words
A purified polypeptide having the amino acid sequence NH 2 -val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr-glu-leu-arg-val-gly-asn-cys-leu-ile-gly-gly-val-ser-phe-thr-cys-cys-thr-arg-val.
Claim 3
Dependent Claim
23 words
A composition which comprises the purified polypeptide of claim 1 in an amount effective to kill bacteria or fungi and a suitable carrier.
Claim 4
Dependent Claim
24 words
A method for killing bacteria or fungi which comprises contacting the bacteria or fungi with an effective amount of the composition of claim 2.
Claim 5
Dependent Claim
10 words
A composition of claim 2 which further comprises a detergent.
Claim 6
Dependent Claim
10 words
A composition of claim 4, wherein the detergent is nonionic.
Claim 7
Dependent Claim
12 words
A composition of claim 2, wherein the suitable carrier comprises a liposome.
References Cited (Backward Citations)
US4705777A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-15 | 1995-01-14 | 1995-07-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-15 | 1999-01-14 | 1999-07-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-15 | 2003-01-14 | 2003-07-16 | $7700.00 | Window Closed / Lapsed |