US5234915A
Expired / Lapsed
US
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Biodegradable gel
Assignee: Novavax Inc
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Filing: 1990-09-24
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Granted: 1993-08-10
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Expires: 2010-09-24
Abstract
Abstract A new gel-like composition of matter containing a complex carbohydrate with a high degree of carboxyl substitution cross-linked by an organic cross-linker has been developed. The cross-linkers have complex ring structures, e.g., polynuclear or heterocyclic compounds, which permit development of two distinct partial positive charges under conditions where a carbohydrate is negatively charged. Antibiotics are the preferred cross-linking agents and a method of sustained release of the antibodies is also disclosed.
Inventors
- 👤 Rajiv Mathur
- 👤 Donald F. H. Wallach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:01
CPC Classifications
C; C08; C08B; C08B15/00; C08B15/005; A; A61; A61F; A61F13/00; A61F13/15; A61F13/15203; A61F13/15252; A61K; A61K47/00; A61K47/30; A61K47/36; A61K47/38; A61K47/50; A61K47/51; A61K47/56; A61K47/61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/28; A61L26/00; A61L26/0009; A61L26/0023; A61L26/0061; A61L26/0066; A61L26/009; A61F13/51; A61F2013/51059; A61F2013/51061; A61F13/53; A61F2013/530481; A61F2013/530583; A61F2013/530649; A61F2013/530795; A61F13/534; A61F2013/53481; A61F13/84; A61F13/8405; A61F2013/8438; A61F2013/8447; A61F2013/8452; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/60; A61L2300/602; A61L2300/80; A61L2300/802
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
77 words
A hydratable biodegradable gel consisting essentially of a callulosic compound with a DS of about 0.5 or greater cross-linked by an amount of an organic cross-linking agent selected from the group consisting of tetracylines, aromatic-substituted imidazoles, and quinolines, said cross-linking agent having at least two partial positive charge locations under conditions where said cellulosic compound has a localized negative charge, the amount of said cross-linking agent being sufficient to cross-link said cellulosic compound to form said gel.
Claim 2
Dependent Claim
77 words
A hydratable biodegradable gel consisting essentially of a callulosic compound with a DS of about 0.5 or greater cross-linked by an amount of an organic cross-linking agent selected from the group consisting of tetracylines, aromatic-substituted imidazoles, and quinolines, said cross-linking agent having at least two partial positive charge locations under conditions where said cellulosic compound has a localized negative charge, the amount of said cross-linking agent being sufficient to cross-link said cellulosic compound to form said gel.
Claim 3
Dependent Claim
20 words
The hydratable biodegradable gel of claim 1 wherein said tetracycline is selected from the group consisting of oxygetracycline and deoxytetracycline.
Claim 4
Dependent Claim
13 words
The hydratable biodegradable gel of claim 1 wherein said aromatic-substituted imidazole is conazole.
Claim 5
Dependent Claim
12 words
The hydratable biodegradable gel of claim 1 wherein said quinoline is norfloxacin.
Claim 6
Independent Claim
124 words
A method of in vivo sustained release of an antibiotic in a body of an animal, comprising the steps of: A. forming a hydratable biodegradable gel, by cross-linking a cullulosic compound with a DS of about 0.5 or greater with an amount of an antibiotic sufficient to cross-link said cellulosic compound and form said gel, said antibiotic selected from the group consisting of tetracylines, aromatic-substituted imidazoles, and quinolines, said antibiotic having at lesat two partial positive charge locations under conditions where said cellulosic compound has a localized negative charge; B. delivering said gel to the body at a location where said sustained release is sought; and C. allowing said gel to dissociate, whereby said antibiotic is released in a sustained manner from said gel.
Claim 7
Independent Claim
124 words
A method of in vivo sustained release of an antibiotic in a body of an animal, comprising the steps of: A. forming a hydratable biodegradable gel, by cross-linking a cullulosic compound with a DS of about 0.5 or greater with an amount of an antibiotic sufficient to cross-link said cellulosic compound and form said gel, said antibiotic selected from the group consisting of tetracylines, aromatic-substituted imidazoles, and quinolines, said antibiotic having at lesat two partial positive charge locations under conditions where said cellulosic compound has a localized negative charge; B. delivering said gel to the body at a location where said sustained release is sought; and C. allowing said gel to dissociate, whereby said antibiotic is released in a sustained manner from said gel.
Claim 8
Dependent Claim
12 words
The method of claim 5 wherein said aromatic-substituted imidazole is a conazole.
Claim 9
Dependent Claim
18 words
The method of claim 5 wherein said tetracycline is selected from the group consisting of oxytetracycline and deoxytetracycline.
Claim 10
Dependent Claim
11 words
The method of claim 5 wherein the animal is a human.
Claim 11
Dependent Claim
10 words
The method of claim 5 wherein said quinoline is norfloxacin.
Claim 12
Dependent Claim
75 words
A hydratable biodegradable gel consisting essentially of a cellulosic compound with a high degree of carboxyl substitution cross-linked by an amount of an organic cross-linking agent selected from the group consisting of oxytetracycline, norfloxacin, miconazole, and econazole, said cross-linking agent having at least two partial positive charges under conditions where said cellulosic compound has a localized negative charge, the amount of said cross-linking agent being sufficient to cross-link said cellulosic compound to form said gel.
Claim 13
Dependent Claim
75 words
A hydratable biodegradable gel consisting essentially of a cellulosic compound with a high degree of carboxyl substitution cross-linked by an amount of an organic cross-linking agent selected from the group consisting of oxytetracycline, norfloxacin, miconazole, and econazole, said cross-linking agent having at least two partial positive charges under conditions where said cellulosic compound has a localized negative charge, the amount of said cross-linking agent being sufficient to cross-link said cellulosic compound to form said gel.
Claim 14
Dependent Claim
74 words
A hydratable biodegradable gel consisting essentially of a cellulosic compound with a high degree of carboxyl substitution cross-linked by an amount of an organic cross-linking agent selected from the group consisting of norfloxacin, miconazole, and econazole, said cross-linking agent having at least two partial positive charges under conditions where said cellulosic compound has a localized negative charge, the amount of said cross-linking agent being sufficient to cross-link said cellulosic compound to form said gel.
Claim 15
Dependent Claim
74 words
A hydratable biodegradable gel consisting essentially of a cellulosic compound with a high degree of carboxyl substitution cross-linked by an amount of an organic cross-linking agent selected from the group consisting of norfloxacin, miconazole, and econazole, said cross-linking agent having at least two partial positive charges under conditions where said cellulosic compound has a localized negative charge, the amount of said cross-linking agent being sufficient to cross-link said cellulosic compound to form said gel.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-09 | 1997-02-08 | 1997-08-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-09 | 2001-02-08 | 2001-08-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-09 | 2005-02-08 | 2005-08-10 | $7700.00 | Window Closed / Lapsed |