US4874850A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical preparations
Assignee: MEDICE CHEM -PHARM FABRIK PUTTER & Co KG KUHLOWEG 37-39 5860 ISERLOHN GERMANY GmbH
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Filing: 1987-08-06
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Granted: 1989-10-17
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Expires: 2007-08-06
Abstract
Abstract A pharmaceutical preparation is disclosed which is made up of a micelle or a vesicle each consisting of a cationic tenside with a monovalent ion and a hydrophobic cyclic or linear peptide, dispersed in a solvent whose pH value lies between pH 7-pH 8, the critical micellization concentration (cmc) lying in the range of 1.0 . 10 -7 to 7.0 . 10 -5 mol/liter. The preparation disclosed have in particular the advantage that by the increasing of the hydrophobicity of the alkyl or aryl chain or the radical at the N + tenside both the membrane permeability is increased and furthermore the pharmaceutical active substance, in particular linear and cyclic tyrocidines (A-E), can be transferred actively into the cytosol. They thus act on the transcription level. In addition, linear and cyclic tyrocidines in particular have antiviral effects.
Inventors
- 👤 Henrich H. Paradies
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:46
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/06; C07D213/16; C07D213/20; A; A61; A61K; A61K47/00; A61K47/06; A61K47/16; A61K47/18; A61K47/186; A61K9/00; A61K9/0012; A61K9/0014; A61K9/10; A61K9/107; A61K9/1075; A61P; A61P17/00; A61P17/16; A61P31/00; A61P31/04; A61P31/12; A61P35/00; A61P43/00; C07D213/24; C07D213/28; C07D213/30; C07D213/60; C07D213/62; C07D213/63; C07D213/65; C07D213/68; C07D213/69; C07D213/72; C07D213/73; C07D213/78; C07D213/79; C07D213/80; C07D213/81; C07D213/82; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07D233/00; C07D233/54; C07D233/56; C07D235/00; C07D235/02; C07D235/04; C07D235/06; C07D239/00; C07D239/02; C07D239/24; C07D239/26; C07D239/28; C07D239/30; C07D239/32; C07D239/34; C07D239/36; C07D239/46; C07D239/47; C07D239/52; C07D239/54; C07D239/545; C07D239/553; C07D241/00; C07D241/02; C07D241/10; C07D241/14; C07D241/24; C07D249/00; C07D249/02; C07D249/08; C07D277/00; C07D277/02; C07D277/20; C07D277/22; C07D277/60; C07D277/62; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/16; C07D473/26; C07D473/32; C07D473/34; C07D473/40; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
78 words
A compound of the formula ##STR59## in which R, n, and x are such that: R is 4-OH, n is 1, and x is 8-20; R is 4--{[CH 3 (CH 2 ) m ] 2 CH--} where m is 8-20, n is 1, and x is 0 or 8-20; or R is 3,5--di--{CH 3 (CH 2 ) m --O--C(O)--} where m is 8-20, n is 2, and x is 0 or 8-20; and y.sup.⊖ is a monovalent anion.
Claim 2
Dependent Claim
78 words
A compound of the formula ##STR59## in which R, n, and x are such that: R is 4-OH, n is 1, and x is 8-20; R is 4--{[CH 3 (CH 2 ) m ] 2 CH--} where m is 8-20, n is 1, and x is 0 or 8-20; or R is 3,5--di--{CH 3 (CH 2 ) m --O--C(O)--} where m is 8-20, n is 2, and x is 0 or 8-20; and y.sup.⊖ is a monovalent anion.
Claim 3
Dependent Claim
31 words
A compound of the formula ##STR60## wherein x is 8 to 20, and y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, or gluconate.
Claim 4
Dependent Claim
31 words
A compound of the formula ##STR60## wherein x is 8 to 20, and y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, or gluconate.
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 2 in which x is 15.
Claim 6
Dependent Claim
39 words
A compound of the formula ##STR61## wherein x is 8 to 20, and y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, gluconate or C 2 H 5 SO 4 - .
Claim 7
Dependent Claim
39 words
A compound of the formula ##STR61## wherein x is 8 to 20, and y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, gluconate or C 2 H 5 SO 4 - .
Claim 8
Dependent Claim
12 words
A compound in accordance with claim 4 in which x is 15.
Claim 9
Dependent Claim
39 words
A compound of the formula ##STR62## wherein x is 8 to 20, and y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, gluconate or C 2 H 5 SO 4 - .
Claim 10
Dependent Claim
39 words
A compound of the formula ##STR62## wherein x is 8 to 20, and y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, gluconate or C 2 H 5 SO 4 - .
Claim 11
Dependent Claim
39 words
A compound of the formula ##STR63## wherein x is 8 to 20, and y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, gluconate or C 2 H 5 SO 4 - .
Claim 12
Dependent Claim
39 words
A compound of the formula ##STR63## wherein x is 8 to 20, and y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, gluconate or C 2 H 5 SO 4 - .
Claim 13
Dependent Claim
33 words
A compound of the formula ##STR64## wherein y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, gluconate or C 2 H 5 SO 4 - .
Claim 14
Dependent Claim
33 words
A compound of the formula ##STR64## wherein y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, gluconate or C 2 H 5 SO 4 - .
Claim 15
Dependent Claim
33 words
A compound of the formula ##STR65## wherein y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, gluconate or C 2 H 5 SO 4 - .
Claim 16
Dependent Claim
33 words
A compound of the formula ##STR65## wherein y.sup.⊖ denotes chloride, bromide, iodide, formate, acetate, propionate, HSO 4 - , malate, fumarate, salicylate, alginate, gluconate or C 2 H 5 SO 4 - .
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-16 | 1993-04-17 | 1993-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-16 | 1997-04-17 | 1997-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-16 | 2001-04-17 | 2001-10-17 | $7700.00 | Window Closed / Lapsed |