US5234404A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
Assignee: Sicor Inc
•
Filing: 1991-10-11
•
Granted: 1993-08-10
•
Expires: 2011-10-11
Abstract
Abstract Methods and devices for the diagnosis, evaluation and treatment of coronary artery disease (CAD) by means of a closed-loop drug delivery system that delivers an exercise simulating agent, including novel exercise simulating agents which elicit both acute and adaptive cardiovascular responses similar to those elicited by aerobic activity are provided. The acute responses to the exercise simulating agent are used to diagnose and evaluate CAD in lieu of the acute responses to aerobic exercise. Due to their adaptive responses these compounds may be used to treat CAD in lieu of the adaptive responses caused by aerobic exercise training or to treat other conditions where the adaptive responses caused by aerobic exercise are desirable.
Inventors
- 👤 Ronald R. Tuttle
- 👤 Clinton E. Browne, III
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 00:26
CPC Classifications
C; C07; C07C; C07C237/00; C07C237/28; C07C237/30; A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/16; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61N1/0432; A61N1/044; A61N1/18; A61N1/32; A61N1/325; C07C215/00; C07C215/46; C07C215/56; C07C215/58; C07C215/60; C07C217/00; C07C217/54; C07C217/56; C07C217/62; C07C45/00; C07C45/27; C07C45/30; C07C45/305; A61N1/0448
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
51 words
A method of eliciting in a mammal immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic activity comprising the administration of an exercise simulating agent with beta adrenergic activity which elicits immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic activity by closed loop drug delivery device.
Claim 2
Independent Claim
51 words
A method of eliciting in a mammal immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic activity comprising the administration of an exercise simulating agent with beta adrenergic activity which elicits immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic activity by closed loop drug delivery device.
Claim 3
Independent Claim
81 words
A method of eliciting in a mammal adaptive cardiovascular and metabolic responses similar to the adaptive cardiovascular and metabolic responses elicited by aerobic activity comprising the administration of an exercise simulating agent with beta adrenergic activity which elicits adaptive cardiovascular and metabolic responses similar to the adaptive cardiovascular and metabolic responses elicited by aerobic activity to a mammal by means of closed loop transdermal iontophoretic infusion for 0.5 to 4.0 hours daily, for a period of from 1 to 30 days.
Claim 4
Independent Claim
81 words
A method of eliciting in a mammal adaptive cardiovascular and metabolic responses similar to the adaptive cardiovascular and metabolic responses elicited by aerobic activity comprising the administration of an exercise simulating agent with beta adrenergic activity which elicits adaptive cardiovascular and metabolic responses similar to the adaptive cardiovascular and metabolic responses elicited by aerobic activity to a mammal by means of closed loop transdermal iontophoretic infusion for 0.5 to 4.0 hours daily, for a period of from 1 to 30 days.
Claim 5
Dependent Claim
89 words
The method of claim 2 wherein said exercise simulating agent has the chemical formula: ##STR9## wherein X 1 and X 2 are independently hydrogen, hydroxy, methoxy or carbamoyl, provided that X 1 and X 2 are not both hydrogen or carbamoyl; one of Y 1 and Y 2 is hydrogen and the other is hydrogen or methyl, provided that if Y 1 is methyl, then X 1 is not carbamoyl; Z is hydrogen or hydroxy; and n is 2 or 3; or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
28 words
The method of claim 3 wherein X 1 is hydrogen, X 2 is hydroxy, Y 1 and Y 2 are hydrogen, Z is hydroxy and n is 3.
Claim 7
Dependent Claim
28 words
The method of claim 3 wherein X 1 is hydrogen, X 2 is methoxy, Y 1 and Y 2 are hydrogen, Z is hydroxy and n is 2.
Claim 8
Independent Claim
111 words
A method of eliciting in a mammal immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic exercise which comprises (a) administering an exercise simulating agent with beta adrenergic activity which elicits immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic exercise to said mammal by a closed loop drug delivery device; (b) controlling infusion of said exercise simulating agent into the bloodstream of said mammal so that a predetermined range of cardiovascular responses of said mammal is obtained; (c) monitoring the range of responses of said mammal; and (d) changing infusion of said exercise simulating agent as required to maintain said range of responses in said mammal.
Claim 9
Independent Claim
111 words
A method of eliciting in a mammal immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic exercise which comprises (a) administering an exercise simulating agent with beta adrenergic activity which elicits immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic exercise to said mammal by a closed loop drug delivery device; (b) controlling infusion of said exercise simulating agent into the bloodstream of said mammal so that a predetermined range of cardiovascular responses of said mammal is obtained; (c) monitoring the range of responses of said mammal; and (d) changing infusion of said exercise simulating agent as required to maintain said range of responses in said mammal.
Claim 10
Independent Claim
196 words
A method of eliciting in a mammal immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic exercise which comprises (a) administering an exercise simulating agent with beta adrenergic activity which elicits immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic exercise to said mammal by a closed loop drug delivery device; (b) controlling infusion of said exercise simulating agent into the bloodstream of said mammal so that a predetermined range of cardiovascular responses of said mammal is obtained; (c) monitoring the range of responses of said mammal; and (d) changing infusion of said exercise simulating agent as required to maintain said range of responses in said mammal; wherein said exercise simulating agent comprises a compound of the formula: wherein X 1 and X 2 are independently hydrogen, hydroxy, methoxy or carbamoyl, provided that X 1 and X 2 are not both hydrogen or carbamoyl; one of Y 1 and Y 2 is hydrogen and the other is hydrogen or methyl, provided that if Y 1 is methyl, then X 1 is not carbamoyl; Z is hydrogen or hydroxy; and n is 2 or 3; or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Independent Claim
196 words
A method of eliciting in a mammal immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic exercise which comprises (a) administering an exercise simulating agent with beta adrenergic activity which elicits immediate cardiovascular responses similar to those cardiovascular responses elicited by aerobic exercise to said mammal by a closed loop drug delivery device; (b) controlling infusion of said exercise simulating agent into the bloodstream of said mammal so that a predetermined range of cardiovascular responses of said mammal is obtained; (c) monitoring the range of responses of said mammal; and (d) changing infusion of said exercise simulating agent as required to maintain said range of responses in said mammal; wherein said exercise simulating agent comprises a compound of the formula: wherein X 1 and X 2 are independently hydrogen, hydroxy, methoxy or carbamoyl, provided that X 1 and X 2 are not both hydrogen or carbamoyl; one of Y 1 and Y 2 is hydrogen and the other is hydrogen or methyl, provided that if Y 1 is methyl, then X 1 is not carbamoyl; Z is hydrogen or hydroxy; and n is 2 or 3; or a pharmaceutically acceptable acid addition salt thereof.
Claim 12
Dependent Claim
21 words
The method of claim 7 wherein said predetermined level of response comprises reversible myocardial ischemia when coronary artery disease is present.
Claim 13
Dependent Claim
18 words
The method of claim 8 wherein said closed loop drug delivery device comprises an intravenous drug delivery device.
Claim 14
Dependent Claim
17 words
The method of claim 8 wherein said closed loop drug delivery device comprises a transdermal iontophoretic device.
Claim 15
Dependent Claim
17 words
The method of claim 8 wherein said exercise simulating agent is a compound wherein Z is hydroxy.
Claim 16
Dependent Claim
34 words
The method of claim 11 wherein said exercise simulating agent is a compound wherein X 1 is hydrogen, X 2 is hydroxy, Y 1 and Y 2 are both hydrogen and n is 3.
Claim 17
Dependent Claim
33 words
The method of claim 11 wherein said exercise simulating agent is a compound wherein X 1 is hydrogen, X 2 is methoxy, Y 1 and Y 2 are hydrogen and n is 2.
Claim 18
Independent Claim
97 words
A method for increasing cardiac contractility in a mammal having depressed cardiac contractility which comprises administering to said mammal an effective amount of a compound of the formula: ##STR10## wherein X 1 and X 2 are independently hydrogen, hydroxy, methoxy or carbamoyl, provided that X 1 and X 2 are not both hydrogen or carbamoyl; one of Y 1 and Y 2 is hydrogen and the other is hydrogen or methyl, provided that if Y 1 is methyl, then X 1 is not carbamoyl; and n is 2 or 3; or a pharmaceutically acceptable addition salt thereof.
Claim 19
Independent Claim
97 words
A method for increasing cardiac contractility in a mammal having depressed cardiac contractility which comprises administering to said mammal an effective amount of a compound of the formula: ##STR10## wherein X 1 and X 2 are independently hydrogen, hydroxy, methoxy or carbamoyl, provided that X 1 and X 2 are not both hydrogen or carbamoyl; one of Y 1 and Y 2 is hydrogen and the other is hydrogen or methyl, provided that if Y 1 is methyl, then X 1 is not carbamoyl; and n is 2 or 3; or a pharmaceutically acceptable addition salt thereof.
Claim 20
Dependent Claim
27 words
The method according to claim 14 wherein X 1 is hydrogen, X 2 is carbamoyl, Y 1 is methyl, Y 2 is hydrogen and n is 2.
Claim 21
Independent Claim
112 words
A method for causing adaptive effects in a mammal which are similar to adaptive responses of said mammal (caused by aerobic exercise over a period of time which comprises administering to said mammal an effective amount of a compound of the formula: ##STR11## wherein X 1 and Y 2 are independently hydrogen, hydroxy, methoxy or carbamoyl, provided that X 1 and X 2 are not both hydrogen or carbamoyl; one of Y 1 and Y 2 is hydrogen and the other is hydrogen or methyl, provided that if Y 1 is methyl, then X 1 is not carbamoyl; and n is 2 or 3; or a pharmaceutically acceptable acid addition salt thereof.
Claim 22
Independent Claim
112 words
A method for causing adaptive effects in a mammal which are similar to adaptive responses of said mammal (caused by aerobic exercise over a period of time which comprises administering to said mammal an effective amount of a compound of the formula: ##STR11## wherein X 1 and Y 2 are independently hydrogen, hydroxy, methoxy or carbamoyl, provided that X 1 and X 2 are not both hydrogen or carbamoyl; one of Y 1 and Y 2 is hydrogen and the other is hydrogen or methyl, provided that if Y 1 is methyl, then X 1 is not carbamoyl; and n is 2 or 3; or a pharmaceutically acceptable acid addition salt thereof.
Claim 23
Dependent Claim
25 words
The method of claim 16 wherein X 1 is hydrogen, X 2 is hydroxy, Y 1 and Y 2 are hydrogen and n is 3.
Claim 24
Dependent Claim
25 words
The method of claim 16 wherein X 1 is hydrogen, X 2 is methoxy, Y 1 and Y 2 are hydrogen and n is 2.
Claim 25
Dependent Claim
26 words
The method of claim 16 wherein X 1 is hydrogen, X 2 is carbamoyl, Y 1 is methyl, Y 2 is hydrogen and n is 2.
References Cited (Backward Citations)
US3803230A
Cited
US3816516A
Cited
US4086272A
Cited
US3987200A
Cited
US4396627A
Cited
US4837305A
Cited
US4562206A
Cited
US4722726A
Cited
US4931046A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-09 | 1997-02-08 | 1997-08-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-09 | 2001-02-08 | 2001-08-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-09 | 2005-02-08 | 2005-08-10 | $7700.00 | Window Closed / Lapsed |