US3987200A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for increasing cardiac contractility
Assignee: Eli Lilly and Co
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Filing: 1975-01-15
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Granted: 1976-10-19
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Expires: 1995-01-15
Abstract
Abstract N-Mono or dihydroxyphenylalkyl dopamine derivatives and salts thereof are inotropic agents useful in a method for treatment of acutely depressed cardiac insufficiency.
Inventors
- 👤 Ronald R. Tuttle
- 👤 Jack Mills
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 04:03
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; C; C07; C07C; C07C45/00; C07C45/45; C07C45/46
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
120 words
The method for increasing cardiac contractility in a warm-blooded mammal suffering from acutely depressed cardiac contractility which comprises administering to said mammal at a rate of between 0.5 and 10 micrograms per kilogram of body weight per minute a compound of the formula ##SPC5## wherein R and R 1 are hydrogen or methyl; R 2 and R 3 are hydrogen or hydroxy, at least one of R 2 and R 3 being hydroxy; n is 1 or 2; subject to the limitation that when n is 2, R 2 is hydrogen and R 3 is hydroxy, one of R or R 1 is hydrogen and the other is methyl; and the pharmaceutically acceptable acid addition salts thereof with mineral acids.
Claim 2
Independent Claim
120 words
The method for increasing cardiac contractility in a warm-blooded mammal suffering from acutely depressed cardiac contractility which comprises administering to said mammal at a rate of between 0.5 and 10 micrograms per kilogram of body weight per minute a compound of the formula ##SPC5## wherein R and R 1 are hydrogen or methyl; R 2 and R 3 are hydrogen or hydroxy, at least one of R 2 and R 3 being hydroxy; n is 1 or 2; subject to the limitation that when n is 2, R 2 is hydrogen and R 3 is hydroxy, one of R or R 1 is hydrogen and the other is methyl; and the pharmaceutically acceptable acid addition salts thereof with mineral acids.
Claim 3
Dependent Claim
136 words
The method of claim 1 wherein the compound administered is a compound of the formula ##SPC6## wherein R and R 1 are hydrogen or methyl; R 2 and R 3 are hydrogen or hydroxy, at least one of R 2 and R 3 being hydroxy; n is 1 or 2; subject to the limitation that when n is 2, R 2 is hydrogen and R 3 is hydroxy, one of R or R 1 is hydrogen and the other is methyl; with the further limitations that when n is 2 and R 2 and R 3 are both hydroxy, then R 1 is hydrogen, and when n is 1, R 2 is hydrogen and R 3 is hydroxy, then R and R 1 are both hydrogen; and the pharmaceutically acceptable acid addition salts with mineral acids.
Claim 4
Dependent Claim
12 words
The method of claim 2 wherein the compound administered is 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methyl-n-propyl]-β-phenethylamine hydrochloride.
Claim 5
Dependent Claim
12 words
The method of claim 2 wherein the compound administered is levo-3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methyl-n-propyl]-β-phenethylamine hydrochloride.
Claim 6
Dependent Claim
12 words
The method of claim 2 wherein the compound administered is 3,4-dihydroxy-N-[3-(3-hydroxyphenyl-n-propyl]-β-phenethylamine hydrochloride.
Claim 7
Dependent Claim
12 words
The method of claim 2 wherein the compound administered is 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-n-propyl]-α-methyl-β-phenethylamine hydrochloride.
Claim 8
Dependent Claim
11 words
The method of claim 2 wherein the compound administered is 3,4-dihydroxy-N-[2-(3,4-dihydroxyphenyl)ethyl]-β-phenethylamine.
Claim 9
Dependent Claim
12 words
The method of claim 2 wherein the compound administered is 3,4-dihydroxy-N-[3-(3,4-dihydroxyphenyl)-n-propyl]-β-phenethylamine hydrochloride.
References Cited (Backward Citations)
US2276619A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-19 | 1980-04-19 | 1980-10-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-19 | 1984-04-19 | 1984-10-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-19 | 1988-04-19 | 1988-10-19 | $7700.00 | Window Closed / Lapsed |