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US5223516A
Expired / Lapsed
US
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3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
Assignee: ER Squibb and Sons LLC
•
Filing: 1991-04-24
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Granted: 1993-06-29
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Expires: 2011-04-24
Abstract
Abstract Compounds of the formula ##STR1## wherein Y can be tetrazolyl are disclosed. These compounds are useful as cardiovascular agents.
Inventors
- 👤 Norma G. Delaney
- 👤 George C. Rovnyak
- 👤 Melanie J. Loots
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 01:57
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06191; C07C; C07C323/00; C07C323/50; C07C323/51; C07C323/60; C07C327/00; C07C327/20; C07C327/32; C07D; C07D207/00; C07D207/02; C07D207/30; C07D207/32; C07D207/33; C07D207/337; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20; C07D209/44; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/54; C07D213/56; C07D213/59; C07D213/60; C07D213/78; C07D213/79; C07D231/00; C07D231/54; C07D231/56; C07D257/00; C07D257/02; C07D257/04; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D307/81; C07D403/00; C07D403/02; C07D403/06
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
77 words
A compound of the formula ##STR52## including all enantiomeric and diasteromeric forms thereof wherein: R 3 is hydrogen or ##STR53## X is ##STR54## n is zero, one, or two; R 5 is lower alkyl, ##STR55## R 4 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, halo, hydroxy, CF 3 , phenyl, ##STR56## q is zero or an integer from 1 to 7.
Claim 2
Dependent Claim
77 words
A compound of the formula ##STR52## including all enantiomeric and diasteromeric forms thereof wherein: R 3 is hydrogen or ##STR53## X is ##STR54## n is zero, one, or two; R 5 is lower alkyl, ##STR55## R 4 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, halo, hydroxy, CF 3 , phenyl, ##STR56## q is zero or an integer from 1 to 7.
Claim 3
Dependent Claim
19 words
A compound of claim 1 wherein X is ##STR57## n is zero; and R 3 is hydrogen or ##STR58##
Claim 4
Dependent Claim
8 words
The compound of claim 2, (S,S)-3,3,3-trifluoro-2-(mercaptomethyl)-N-[2-(1H-indol-3-yl)-1-(1H-tetrazol-5-yl)ethyl]propanamide or (S,R)-3,3,3-trifluoro-2-(mercaptomethyl)-N-[2-(1H-indol-3-yl)-1-(1H-tetrazol-5-yl)ethyl]propanamide.
Claim 5
Dependent Claim
19 words
A compound of claim 1 wherein X is ##STR59## n is zero; and R 3 is hydrogen or ##STR60##
Claim 6
Dependent Claim
6 words
The compound of claim 3, (S,R)-3,3,3-trifluoro-2-(mercaptomethyl)-N-[2-(1H-indol-3-yl)-1-(1H-tetrazol-5-yl)ethyl]propanamide.
Claim 7
Dependent Claim
24 words
A compound of the formula; ##STR61## including all enantiomeric and disastereomeric forms thereof wherein R 3 is hydrogen or ##STR62## and X is ##STR63##
Claim 8
Dependent Claim
24 words
A compound of the formula; ##STR61## including all enantiomeric and disastereomeric forms thereof wherein R 3 is hydrogen or ##STR62## and X is ##STR63##
Claim 9
Dependent Claim
54 words
A pharmaceutical composition useful for reducing blood pressure and producing diuresis and natriuresis as well as treating congestive heart failure, renal failure, or hepatic cirrhosis comprising a pharmaceutically acceptable carrier and an effective amount of an endopeptidase inhibiting compound of the formula ##STR64## wherein X and R 3 are as defined in claim 6.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-28 | 1996-12-28 | 1997-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-28 | 2000-12-28 | 2001-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-28 | 2004-12-28 | 2005-06-29 | $7700.00 | Window Closed / Lapsed |