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US5221668A Expired / Lapsed US ⏱️ 0.0 years remaining

Nutritional product for trauma and surgery patients

Assignee: Abbott Laboratories
•
Filing: 1992-02-26
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Granted: 1993-06-22
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Expires: 2012-02-26
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Abstract

Abstract A liquid nutritional product for trauma and surgery patients has a caloric density of about 1.2 to 1.5 Kcal/mL and a calorie to nitrogen ratio of about 112:1 to 145:1. A portion of the protein system comprises partially digested protein, and supplemental L-arginine provides about 1-3% of the total calories in the product. The lipid system has a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1.

Inventors

  • 👤 Mary F. Henningfield
  • 👤 John W. McEwen
  • 👤 Robert H. Miller

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-09 07:44
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/01; A61K38/012; A61K38/018; A23; A23L; A23L33/00; A23L33/10; A23L33/115; A23L33/12; A23L33/15; A23L33/17; A23L33/175; A23L33/18; A23L33/40; A61P; A61P3/00; A23V; A23V2002/00; Y; Y10; Y10S; Y10S426/00; Y10S426/80; Y10S426/801; Y10S426/81

Claims Analysis

Total Claims: 29
Claim 1
Independent Claim 89 words
A liquid nutritional product comprising: a protein system comprising by weight about 20-30% lactalbumin hydrolysate, about 60-70% partially hydrolyzed sodium caseinate, and about 8-14% L-arginine, supplemental L-arginine providing about 1-3% of the total calories in the nutritional product; and a lipid system having a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1, said nutritional product having a caloric density in the range of about 1.2 to 1.5 kcal/ml and a calorie to nitrogen ratio of about 112:1 to about 145:1.
Claim 2
Dependent Claim 89 words
A liquid nutritional product comprising: a protein system comprising by weight about 20-30% lactalbumin hydrolysate, about 60-70% partially hydrolyzed sodium caseinate, and about 8-14% L-arginine, supplemental L-arginine providing about 1-3% of the total calories in the nutritional product; and a lipid system having a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1, said nutritional product having a caloric density in the range of about 1.2 to 1.5 kcal/ml and a calorie to nitrogen ratio of about 112:1 to about 145:1.
Claim 3
Dependent Claim 20 words
A liquid nutritional product according to claim 1 wherein the nutritional product has a caloric density of about 1.3 kcal/ml.
Claim 4
Dependent Claim 37 words
A liquid nutritional product according to claim 1 wherein about 18-24% of the calories are provided by protein, about 20-30% of the calories are provided by lipids, and about 46-62% of the calories are provided by carbohyd-rates.
Claim 5
Dependent Claim 37 words
A liquid nutritional product according to claim 2 wherein about 18-24% of the calories are provided by protein, about 20-30% of the calories are provided by lipids, and about 46-62% of the calories are provided by carbohydrates.
Claim 6
Dependent Claim 29 words
A liquid nutritional product according to claim 1 wherein the lipid system comprises by weight about 35-55% canola oil, about 30-50% medium chai-n triglycerides and about 5-35% corn oil.
Claim 7
Dependent Claim 29 words
A liquid nutritional product according to claim 2 wherein the lipid system comprises by weight about 35-55% canola oil, about 30-50% medium chain triglycerides and about 5-35% corn oil.
Claim 8
Dependent Claim 29 words
A liquid nutritional product according to claim 3 wherein the lipid system comprises by weight about 35-55% canola oil, about 30-50% medium chain triglycerides and about 5-35% corn oil.
Claim 9
Dependent Claim 29 words
A liquid nutritional product according to claim 4 wherein the lipid system comprises by weight about 35-55% canola oil, about 30-50% medium chain triglycerides and about 5-35% corn oil.
Claim 10
Dependent Claim 20 words
A liquid nutritional product according to any one of claims 1-8 further comprising hydrolyzed corn starch as a carbohydrate source.
Claim 11
Dependent Claim 181 words
A liquid nutritional product comprising: (a) a protein system which provides about 18-24% of the calories provided by the product, said protein system including (i) partially hydrolyzed protein and (ii) supplemental L-arginine in an amount sufficient to provide about 1-3% of the total calories provided by the product; (b) a lipid system which provides about 20-30% of the calories provided by the product, said lipid system having a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1; and (c) carbohydrates which provide about 46-62% of the calories provided by the product, the product having a caloric density in the range of about 1.2 to 1.5 kcal/ml a calorie to nitrogen ratio of about 112:1 to about 145:1, and having the following amino acid profile: ______________________________________ AMINO ACID g/100 g protein ______________________________________ Histidine 1.7-2.4 Isoleucine 4.1-5.1 Leucine 7.9-12.5 Lysine 5.5-9.4 Methionine 2.1-2.9 Phenylalanine 3.5-4.9 Threonine 3.9-5.3 Tryptophan 1.1-2.0 Valine 4.8-6.5 Alanine 2.9-4.4 Arginine (Includes inherent arginine) 9.0-14.5 Aspartic Acid 6.5-10.00 Cystine 0.7-2.2 Glutamic Acid 17.5-20.5 Glycine 1.5-1.9 Proline 6.5-9.0 Serine 4.8-5.1 Tyrosine 3.7-5.1. ______________________________________
Claim 12
Dependent Claim 181 words
A liquid nutritional product comprising: (a) a protein system which provides about 18-24% of the calories provided by the product, said protein system including (i) partially hydrolyzed protein and (ii) supplemental L-arginine in an amount sufficient to provide about 1-3% of the total calories provided by the product; (b) a lipid system which provides about 20-30% of the calories provided by the product, said lipid system having a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1; and (c) carbohydrates which provide about 46-62% of the calories provided by the product, the product having a caloric density in the range of about 1.2 to 1.5 kcal/ml a calorie to nitrogen ratio of about 112:1 to about 145:1, and having the following amino acid profile: ______________________________________ AMINO ACID g/100 g protein ______________________________________ Histidine 1.7-2.4 Isoleucine 4.1-5.1 Leucine 7.9-12.5 Lysine 5.5-9.4 Methionine 2.1-2.9 Phenylalanine 3.5-4.9 Threonine 3.9-5.3 Tryptophan 1.1-2.0 Valine 4.8-6.5 Alanine 2.9-4.4 Arginine (Includes inherent arginine) 9.0-14.5 Aspartic Acid 6.5-10.00 Cystine 0.7-2.2 Glutamic Acid 17.5-20.5 Glycine 1.5-1.9 Proline 6.5-9.0 Serine 4.8-5.1 Tyrosine 3.7-5.1. ______________________________________
Claim 13
Dependent Claim 61 words
A liquid nutritional product according to claim 10 wherein said product has the following fatty acid profile: ______________________________________ FATTY ACID % Total Fatty Acids ______________________________________ Linoleic (18:2ω6) 19-24 α-Linolenic (18:3ω3) 3.5-12 Caprylic (8:0) 18-26 Capric (10:0) 10.2-15.5 Lauric (12:0) trace-0.4 Myristic (14:0) trace-0.7 Palmitic (16:0) 4.0-7.2 Stearic (18:0) trace-1.9 Oleic (18:1ω9) 20-55 Arachidic (20:0) trace-0.6 Eiosenoic (20:1ω9) trace-0.6 Others trace-10. ______________________________________
Claim 14
Dependent Claim 19 words
A liquid nutritional product according to claim 10 wherein the product has a caloric density of about 1.3 kcal/ml.
Claim 15
Dependent Claim 19 words
A liquid nutritional product according to claim 11 wherein the product has a caloric density of about 1.3 kcal/ml.
Claim 16
Dependent Claim 19 words
A liquid nutritional product according to claims 10 wherein the product has viscosity of not greater than 55 cps.
Claim 17
Dependent Claim 20 words
A liquid nutritional product according to claim 11 wherein the product has a viscosity of not greater than 55 cps.
Claim 18
Dependent Claim 20 words
A liquid nutritional product according to claim 12 wherein the product has a viscosity of not greater than 55 cps.
Claim 19
Dependent Claim 20 words
A liquid nutritional product according to claim 13 wherein the product has a viscosity of not greater than 55 cps.
Claim 20
Dependent Claim 17 words
A liquid nutritional product according to one of claims 10-17 further comprising a source of dietary fiber.
Claim 21
Dependent Claim 163 words
A liquid nutritional product comprising (a) a protein system comprising by weight about 20-30% lactalbumin hydrolysate, about 62-68% partially hydrolyzed sodium caseinate, and about 8-12% L-arginine, supplemental L-arginine providing about 1-3% of the total calories in the nutritional product; (b) a lipid system comprising by weight about 35-45% canola oil, about 35-45% medium chain triglycerides, and about 10-30% corn oil, the lipid system providing a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1; and (c) a carbohydrate system comprising hydrolyzed corn starch, the nutritional product having (i) a caloric density of about 1.3 kcal/ml, (ii) a caloric distribution such that about 18-24% of the calories are provided by proteins, about 20-30% of the calories are provided by lipids and about 46-62% of the calories are provided by carbohydrates, (iii) the nutritional product has a viscosity of not greater than 55 cps, and (iv) a calorie to nitrogen ratio of about 112:1 to about 145:1.
Claim 22
Dependent Claim 163 words
A liquid nutritional product comprising (a) a protein system comprising by weight about 20-30% lactalbumin hydrolysate, about 62-68% partially hydrolyzed sodium caseinate, and about 8-12% L-arginine, supplemental L-arginine providing about 1-3% of the total calories in the nutritional product; (b) a lipid system comprising by weight about 35-45% canola oil, about 35-45% medium chain triglycerides, and about 10-30% corn oil, the lipid system providing a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1; and (c) a carbohydrate system comprising hydrolyzed corn starch, the nutritional product having (i) a caloric density of about 1.3 kcal/ml, (ii) a caloric distribution such that about 18-24% of the calories are provided by proteins, about 20-30% of the calories are provided by lipids and about 46-62% of the calories are provided by carbohydrates, (iii) the nutritional product has a viscosity of not greater than 55 cps, and (iv) a calorie to nitrogen ratio of about 112:1 to about 145:1.
Claim 23
Dependent Claim 11 words
A liquid nutritional product according to claim 19 further comprising carrageenan.
Claim 24
Dependent Claim 59 words
A liquid nutritional product according to claim 20 wherein a quantity of said product sufficient to provide 1,500 kcal will provide at least 100% of the U.S. RDA of Vitamin A, Vitamin D, Vitamin E, Vitamin K, Vitamin C, Folic Acid, Thiamin, Riboflavin, Vitamin B-6, Vitamin B-12, Niacin, Biotin, Pantothenic Acid, Calcium, Phosphorus, Magnesium, Iodine, Copper, Zinc and Iron.
Claim 25
Dependent Claim 59 words
A liquid nutritional product according to claim 21 wherein a quantity of said product sufficient to provide 1,500 kcal will provide at least 100% of the U.S. RDA of Vitamin A, Vitamin D, Vitamin E, Vitamin K, Vitamin C, Folic Acid, Thiamin, Riboflavin, Vitamin B-6, Vitamin B-12, Niacin, Biotin, Pantothenic Acid, Calcium, Phosphorus, Magnesium, Iodine, Copper, Zinc and Iron.
Claim 26
Dependent Claim 12 words
A liquid nutritional product according to claim 20 further comprising beta carotene.
Claim 27
Dependent Claim 12 words
A liquid nutritional product according to claim 21 further comprising beta carotene.
Claim 28
Dependent Claim 12 words
A liquid nutritional product aocording to claim 22 further comprising beta carotene.
Claim 29
Dependent Claim 12 words
A liquid nutritional product according to claim 23 further comprising beta carotene.

References Cited (Backward Citations)

US4042688A Cited
US4438144A Cited
AU3691784A Cited
JPS61192245A Cited
US4850704A Cited
US4920098A Cited
US5053387A Cited
EP0312612A1 Cited
EP0362724A2 Cited
WO1991009524A1 Cited
US5085883A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1996-06-21 1996-12-21 1997-06-22 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2000-06-21 2000-12-21 2001-06-22 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2004-06-21 2004-12-21 2005-06-22 $7700.00 Window Closed / Lapsed

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