Patent US5221668A successfully refreshed from Google Patents.
US5221668A
Expired / Lapsed
US
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Nutritional product for trauma and surgery patients
Assignee: Abbott Laboratories
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Filing: 1992-02-26
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Granted: 1993-06-22
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Expires: 2012-02-26
Abstract
Abstract A liquid nutritional product for trauma and surgery patients has a caloric density of about 1.2 to 1.5 Kcal/mL and a calorie to nitrogen ratio of about 112:1 to 145:1. A portion of the protein system comprises partially digested protein, and supplemental L-arginine provides about 1-3% of the total calories in the product. The lipid system has a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1.
Inventors
- 👤 Mary F. Henningfield
- 👤 John W. McEwen
- 👤 Robert H. Miller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 07:44
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/01; A61K38/012; A61K38/018; A23; A23L; A23L33/00; A23L33/10; A23L33/115; A23L33/12; A23L33/15; A23L33/17; A23L33/175; A23L33/18; A23L33/40; A61P; A61P3/00; A23V; A23V2002/00; Y; Y10; Y10S; Y10S426/00; Y10S426/80; Y10S426/801; Y10S426/81
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
89 words
A liquid nutritional product comprising: a protein system comprising by weight about 20-30% lactalbumin hydrolysate, about 60-70% partially hydrolyzed sodium caseinate, and about 8-14% L-arginine, supplemental L-arginine providing about 1-3% of the total calories in the nutritional product; and a lipid system having a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1, said nutritional product having a caloric density in the range of about 1.2 to 1.5 kcal/ml and a calorie to nitrogen ratio of about 112:1 to about 145:1.
Claim 2
Dependent Claim
89 words
A liquid nutritional product comprising: a protein system comprising by weight about 20-30% lactalbumin hydrolysate, about 60-70% partially hydrolyzed sodium caseinate, and about 8-14% L-arginine, supplemental L-arginine providing about 1-3% of the total calories in the nutritional product; and a lipid system having a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1, said nutritional product having a caloric density in the range of about 1.2 to 1.5 kcal/ml and a calorie to nitrogen ratio of about 112:1 to about 145:1.
Claim 3
Dependent Claim
20 words
A liquid nutritional product according to claim 1 wherein the nutritional product has a caloric density of about 1.3 kcal/ml.
Claim 4
Dependent Claim
37 words
A liquid nutritional product according to claim 1 wherein about 18-24% of the calories are provided by protein, about 20-30% of the calories are provided by lipids, and about 46-62% of the calories are provided by carbohyd-rates.
Claim 5
Dependent Claim
37 words
A liquid nutritional product according to claim 2 wherein about 18-24% of the calories are provided by protein, about 20-30% of the calories are provided by lipids, and about 46-62% of the calories are provided by carbohydrates.
Claim 6
Dependent Claim
29 words
A liquid nutritional product according to claim 1 wherein the lipid system comprises by weight about 35-55% canola oil, about 30-50% medium chai-n triglycerides and about 5-35% corn oil.
Claim 7
Dependent Claim
29 words
A liquid nutritional product according to claim 2 wherein the lipid system comprises by weight about 35-55% canola oil, about 30-50% medium chain triglycerides and about 5-35% corn oil.
Claim 8
Dependent Claim
29 words
A liquid nutritional product according to claim 3 wherein the lipid system comprises by weight about 35-55% canola oil, about 30-50% medium chain triglycerides and about 5-35% corn oil.
Claim 9
Dependent Claim
29 words
A liquid nutritional product according to claim 4 wherein the lipid system comprises by weight about 35-55% canola oil, about 30-50% medium chain triglycerides and about 5-35% corn oil.
Claim 10
Dependent Claim
20 words
A liquid nutritional product according to any one of claims 1-8 further comprising hydrolyzed corn starch as a carbohydrate source.
Claim 11
Dependent Claim
181 words
A liquid nutritional product comprising: (a) a protein system which provides about 18-24% of the calories provided by the product, said protein system including (i) partially hydrolyzed protein and (ii) supplemental L-arginine in an amount sufficient to provide about 1-3% of the total calories provided by the product; (b) a lipid system which provides about 20-30% of the calories provided by the product, said lipid system having a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1; and (c) carbohydrates which provide about 46-62% of the calories provided by the product, the product having a caloric density in the range of about 1.2 to 1.5 kcal/ml a calorie to nitrogen ratio of about 112:1 to about 145:1, and having the following amino acid profile: ______________________________________
AMINO ACID g/100 g protein
______________________________________
Histidine 1.7-2.4
Isoleucine 4.1-5.1
Leucine 7.9-12.5
Lysine 5.5-9.4
Methionine 2.1-2.9
Phenylalanine 3.5-4.9
Threonine 3.9-5.3
Tryptophan 1.1-2.0
Valine 4.8-6.5
Alanine 2.9-4.4
Arginine (Includes inherent arginine)
9.0-14.5
Aspartic Acid 6.5-10.00
Cystine 0.7-2.2
Glutamic Acid 17.5-20.5
Glycine 1.5-1.9
Proline 6.5-9.0
Serine 4.8-5.1
Tyrosine 3.7-5.1.
______________________________________
Claim 12
Dependent Claim
181 words
A liquid nutritional product comprising: (a) a protein system which provides about 18-24% of the calories provided by the product, said protein system including (i) partially hydrolyzed protein and (ii) supplemental L-arginine in an amount sufficient to provide about 1-3% of the total calories provided by the product; (b) a lipid system which provides about 20-30% of the calories provided by the product, said lipid system having a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1; and (c) carbohydrates which provide about 46-62% of the calories provided by the product, the product having a caloric density in the range of about 1.2 to 1.5 kcal/ml a calorie to nitrogen ratio of about 112:1 to about 145:1, and having the following amino acid profile: ______________________________________
AMINO ACID g/100 g protein
______________________________________
Histidine 1.7-2.4
Isoleucine 4.1-5.1
Leucine 7.9-12.5
Lysine 5.5-9.4
Methionine 2.1-2.9
Phenylalanine 3.5-4.9
Threonine 3.9-5.3
Tryptophan 1.1-2.0
Valine 4.8-6.5
Alanine 2.9-4.4
Arginine (Includes inherent arginine)
9.0-14.5
Aspartic Acid 6.5-10.00
Cystine 0.7-2.2
Glutamic Acid 17.5-20.5
Glycine 1.5-1.9
Proline 6.5-9.0
Serine 4.8-5.1
Tyrosine 3.7-5.1.
______________________________________
Claim 13
Dependent Claim
61 words
A liquid nutritional product according to claim 10 wherein said product has the following fatty acid profile: ______________________________________
FATTY ACID % Total Fatty Acids
______________________________________
Linoleic (18:2ω6)
19-24
α-Linolenic (18:3ω3)
3.5-12
Caprylic (8:0) 18-26
Capric (10:0) 10.2-15.5
Lauric (12:0) trace-0.4
Myristic (14:0) trace-0.7
Palmitic (16:0) 4.0-7.2
Stearic (18:0) trace-1.9
Oleic (18:1ω9)
20-55
Arachidic (20:0)
trace-0.6
Eiosenoic (20:1ω9)
trace-0.6
Others trace-10.
______________________________________
Claim 14
Dependent Claim
19 words
A liquid nutritional product according to claim 10 wherein the product has a caloric density of about 1.3 kcal/ml.
Claim 15
Dependent Claim
19 words
A liquid nutritional product according to claim 11 wherein the product has a caloric density of about 1.3 kcal/ml.
Claim 16
Dependent Claim
19 words
A liquid nutritional product according to claims 10 wherein the product has viscosity of not greater than 55 cps.
Claim 17
Dependent Claim
20 words
A liquid nutritional product according to claim 11 wherein the product has a viscosity of not greater than 55 cps.
Claim 18
Dependent Claim
20 words
A liquid nutritional product according to claim 12 wherein the product has a viscosity of not greater than 55 cps.
Claim 19
Dependent Claim
20 words
A liquid nutritional product according to claim 13 wherein the product has a viscosity of not greater than 55 cps.
Claim 20
Dependent Claim
17 words
A liquid nutritional product according to one of claims 10-17 further comprising a source of dietary fiber.
Claim 21
Dependent Claim
163 words
A liquid nutritional product comprising (a) a protein system comprising by weight about 20-30% lactalbumin hydrolysate, about 62-68% partially hydrolyzed sodium caseinate, and about 8-12% L-arginine, supplemental L-arginine providing about 1-3% of the total calories in the nutritional product; (b) a lipid system comprising by weight about 35-45% canola oil, about 35-45% medium chain triglycerides, and about 10-30% corn oil, the lipid system providing a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1; and (c) a carbohydrate system comprising hydrolyzed corn starch, the nutritional product having (i) a caloric density of about 1.3 kcal/ml, (ii) a caloric distribution such that about 18-24% of the calories are provided by proteins, about 20-30% of the calories are provided by lipids and about 46-62% of the calories are provided by carbohydrates, (iii) the nutritional product has a viscosity of not greater than 55 cps, and (iv) a calorie to nitrogen ratio of about 112:1 to about 145:1.
Claim 22
Dependent Claim
163 words
A liquid nutritional product comprising (a) a protein system comprising by weight about 20-30% lactalbumin hydrolysate, about 62-68% partially hydrolyzed sodium caseinate, and about 8-12% L-arginine, supplemental L-arginine providing about 1-3% of the total calories in the nutritional product; (b) a lipid system comprising by weight about 35-45% canola oil, about 35-45% medium chain triglycerides, and about 10-30% corn oil, the lipid system providing a ratio of linoleic acid to alpha linoleic acid in the range of about 3.5:1 to about 5.5:1; and (c) a carbohydrate system comprising hydrolyzed corn starch, the nutritional product having (i) a caloric density of about 1.3 kcal/ml, (ii) a caloric distribution such that about 18-24% of the calories are provided by proteins, about 20-30% of the calories are provided by lipids and about 46-62% of the calories are provided by carbohydrates, (iii) the nutritional product has a viscosity of not greater than 55 cps, and (iv) a calorie to nitrogen ratio of about 112:1 to about 145:1.
Claim 23
Dependent Claim
11 words
A liquid nutritional product according to claim 19 further comprising carrageenan.
Claim 24
Dependent Claim
59 words
A liquid nutritional product according to claim 20 wherein a quantity of said product sufficient to provide 1,500 kcal will provide at least 100% of the U.S. RDA of Vitamin A, Vitamin D, Vitamin E, Vitamin K, Vitamin C, Folic Acid, Thiamin, Riboflavin, Vitamin B-6, Vitamin B-12, Niacin, Biotin, Pantothenic Acid, Calcium, Phosphorus, Magnesium, Iodine, Copper, Zinc and Iron.
Claim 25
Dependent Claim
59 words
A liquid nutritional product according to claim 21 wherein a quantity of said product sufficient to provide 1,500 kcal will provide at least 100% of the U.S. RDA of Vitamin A, Vitamin D, Vitamin E, Vitamin K, Vitamin C, Folic Acid, Thiamin, Riboflavin, Vitamin B-6, Vitamin B-12, Niacin, Biotin, Pantothenic Acid, Calcium, Phosphorus, Magnesium, Iodine, Copper, Zinc and Iron.
Claim 26
Dependent Claim
12 words
A liquid nutritional product according to claim 20 further comprising beta carotene.
Claim 27
Dependent Claim
12 words
A liquid nutritional product according to claim 21 further comprising beta carotene.
Claim 28
Dependent Claim
12 words
A liquid nutritional product aocording to claim 22 further comprising beta carotene.
Claim 29
Dependent Claim
12 words
A liquid nutritional product according to claim 23 further comprising beta carotene.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-21 | 1996-12-21 | 1997-06-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-21 | 2000-12-21 | 2001-06-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-21 | 2004-12-21 | 2005-06-22 | $7700.00 | Window Closed / Lapsed |